Therapeutic efficacy of connective tissue autotransplants with periosteum and platelet rich plasma in the menagement of gingival recession
Abstract
Background/Aim. Gingival recession progression in clinical practice has influenced the development of various surgical procedures and techniques for solving esthetic imperfections and subjective difficulties coused by gingival recession. The aim of this study was to verify efficacy of surgical procedures and to compare both of surgical procedures through the keratinized tissue width. Methods. The study included 20 teeth with gingival recesion, Müller class I and II. Ten teeth with gingival recession were treated with connective tissue autotransplants with periosteum in combination with coronary guided surgical flap (CTG group). On the contralateral side 10 teeth with gingival recession were treated with the same surgical procedures but in combination with platelet-rich plasma (CTG-PRP group). We measured the keratinized tissue width. For statistical significance we used the Student's t-test. Results. The study reveled a statistical significance in reducing vertical deepress of recession by both used treatments. Root deepness in CTG and CTG-PRP group was 90% and 93.5%, respectively. With both surgical techniques we achieved larger zone of keratinized gingiva but with a wide zone of keratinized tissue in CTG – the PRP group. Conclusion. The concept regeneration technique with PRP and with the stimulating influence of platele activated growth factors results in the regeneration of deep periodontal tissue as an important prerequisite for the successfull treatment of gingival recession.
References
American Academy of Periodontology. Glossary of Periodontol Terms. 3rd ed. Chicago: The American Academy of Periodon-tology; 1992.
Kassab MM, Cohen RE. The etiology and prevalence of gingival recession. J Am Dent Assoc 2003; 134(2): 220–5.
Stevanović R, Zelić O. Coronary tissue graft for treatment of gin-gival recession. Stom Glas S 2003; 50(3): 144–9. (Serbian)
Corauza FA, Newman C. Clinical periodontology. 8th ed. Philadelphia: WB Sanders Company; 1996.
Trombelli L. Periodontal regeneration in gingival recession de-fects. Periodontol 2000 1999; 19: 138–50.
Miller PD Jr, Allen EP. The development of periodontal plastic surgery. Periodontol 2000 1996; 11: 7–17.
Janković S, Dimitrijević B. Mogućnosti savremenih procedura u terapiji gingivalnih recesija. Stom Glas S 2003; 50(1): 18–23. (Serbian)
Muller HP, Stahl M, Eger T. Dynamics of mucosal dimensions after root coverage with a bioresorbable membrane. J Clin Pe-riodontol 2000; 27(1): 1–8.
Harris R. Histologic evaluation of connective tissue grafts in humans. Int J Periodontics Restorative Dent 2003; 23(6): 575−83.
Lazić Z, Bubalo M, Petković-Ćurčin A, Duka M, Mihajlović B. Therapeutic use of platelet-rich plasma in oral surgery. Vojno-sanit Pregl 2009; 66(10): 821–5. (Serbian)
Marx RE. Platelet rich-plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62(4): 489–96.
Lazić Z, Mirković Z. Growth factors in bone regeneration. Bel-grade: Zadužbina Andrejević 2007. (Serbian)
Creeper F, Lichanska AM, Marshall RI, Seymour GJ, Ivanovski S. The effect of platelet reach plasma on osteoblast and peri-odontal ligament cell migration, proliferation and differentia-tion. J Periodontal Res 2009; 44(2): 258–65.
Jakse N, Tangl S, Gilli R, Berghold A, Lorenzoni M, Eskici A, et al. Influence of PRP on autogenous sinus grafts. An experimental study on sheep. Clin Oral Implants Res 2003; 14(5): 578–83.
Ainamo J, Loe H. Anatomical characteristics of gingiva. A clinical and miscrocsope study of the free and attached gingiva. J Clin Periodontol 1996; 37(1): 5−13.
Miller PD, Allen EP. The Development of periodontal plastic surgery. Periodontology 2000; 11: 7–17.
Roccuzzo M, Bunino M, Needleman I, Sanz M. Periodontal plastic surgery for treatment of localized gingival recessions: A syste-matic review. J Clin Periodontol 2002; 29(Suppl. 3): 178–94.
Lung NP, Loe H. The relationship between the width of kerati-nized gingiva and gingival health. J Periodontol 1972; 43(10): 623−7.
Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999; 14(4): 529−35.
Sonnleitner D, Huemer P, Sullivan DY. A simplified technique for producing platelet-rich plasma and platelet concentrate for intraoral bone grafting techniques: a technical note. Int J Oral Maxillofac Implants 2000; 15(6): 879−82.
Carnio J, Camargo PM, Kenney EB, Schenk RK. Histological eval-uation of 4 cases of root coverage following a connective tis-sue graft combined with an enamel matrix derivative prepara-tion. J Periodontol 2002; 73(12): 1534−43.
Martínez-Zapata MJ, Martí-Carvajal A, Solà I, Bolibar I, Angel Expósito J, Rodriguez L, et al.. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion 2009; 49(1): 44−56.
Goldstein M, Boyan BD, Cochran DL, Schwarz Z. Human histolo-gy of new attachment after root coverage using subepithelial connective tissue graft. J Clin Periodontol 2001; 28(7): 657–62.
Sonick M, Hwang D. The dependability of connective tissue grafting for the resolution of full mouth recession. Compend Contin Educ Dent 2011; 32(1): 48–53.
Harris R. A comparative Study of Root Coverage Obtained with Guided Tissue Regeneration Utilizing a Bioabsorbable Membrane Versus the Connective Tissue with Partial-Thickness Double Pedicle Graft. J Periodontol 1997; 68(8): 779−90.
Huang LH, Neiva RE, Soehren SE, Giannobile WV, Wang HL. The effect of platelet-rich plasma on the coronally advanced flap root coverage procedure: a pilot human trial. J Periodon-tol 2005; 76(10): 1768–77.
Anilkumar K, Geetha A, Umasudhakar, Ramakrishnan T, Vijaya-lakshmi R, Pameela E. Platelet-rich-fibrin: A novel root cover-age approach. J Indian Soc Periodontol 2009; 13(1): 50−4.
Aleksić Z, Janković S, Dimitrijević B, Pucar A, Lazić V, Leković V. Clinical impact of platelet rich plasma in treatment of gingival recessions. Srp Arh Celok Lek 2008; 136(3–4): 95–103. (Serbian)
Aleksić Z, Janković S, Dimitrijević B, Divić RT, Milinković I, Leković V. The use of platelet rich fibrin membrane in gingival recession treatment. Srp Arh Celok Lek 2010; 138(1–2): 11–8. (Serbian)
McGuire MK, Scheyer ET, Schupbach P. Growth factor mediated treatment of recession defects a randomized controlled trial and histologic and microcomputed tomography examination. J Periodontol 2009; 80(4): 550−64.
Kawase T, Okuda K, Wolff LF, Yoshie H. Platelet rich plasma derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Peri-odontol 2003; 74(69: 858−64.
Zucchelli G, Mele M, Stefanini M, Mazzoti C, Mounssif M, Marzadori M, et al. Predetermination of root coverage. J Periodontol 2010; 81(7): 1019–26.
Suaid FF, Carvalho MD, Santamaria MP, Casati MZ, Nociti FH Jr, Sallum AW, et al.. Platelet-rich plasma and connective tissue grafts in the treatment of gingival recessions: a histometric study in dogs. J Periodontol 2008; 79(5): 888–95.
