Melanoma of the sinonasal mucosa: A report on the two cases and a review of the literature

Aleksandra Aleksić; Radoslav Gajanin; Dejan Djurdjević; Zorica Novaković; Dalibor Vranješ; Slobodan Spremo; Dmitar Travar; Nataša Guzina-Golac; Vesna Tomić-Spirić

doi:10.2298/5893

Aleksandra Aleksić Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Radoslav Gajanin Department for Pathology, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Dejan Djurdjević Department of Maxillofacial Surgery, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Zorica Novaković Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Dalibor Vranješ Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Slobodan Spremo Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Dmitar Travar Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Nataša Guzina-Golac Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Vesna Tomić-Spirić Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

DOI: https://doi.org/10.2298/5893

Keywords: melanoma, nose, paranasal sinuses, diagnosis, neoplasms staging, oral surgical procedures, radiotherapy, treatment outcome, prognosis,

Abstract

Introduction. Primary mucosal melanoma of the sinonasal tract is a rare neoplasm, accounting for less than 1% of all melanomas. It has an aggressive and unpredictable biologic behavior characterized by frequent incidence of local recurrence, local and distant metastasis of the disease. Case report. This report summarizes the results of the previous research concerning sinonasal mucosal melanoma, and by the example of the two patients suffering from mucosal melanoma, we described clinical and histopathological features of this rare neoplasm and our experience in its diagnosis and treatment. Conclusion. Only histopathological analysis complemented by immunohistochemical analysis contributes to early and accurate diagnosis of the disease.

Author Biographies

Aleksandra Aleksić, Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Mr.sc.med.specijalista otorinolaringolog, subspecijalista alergolog

Radoslav Gajanin, Department for Pathology, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

prof.dr.specijalista patolog

Dejan Djurdjević, Department of Maxillofacial Surgery, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Specijalista maksilofacijalni hirurg

Zorica Novaković, Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Mr sc.med.specijalista otorinolaringolog

Dalibor Vranješ, Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Mr sc.med.specijalista otorinolaringolog

Slobodan Spremo, Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

Prof.dr.specijalista otorinolaringolog

Dmitar Travar, Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

doc.dr.specijalista otorinolaringolog

Nataša Guzina-Golac, Department of Ear, Throat and Nose, Clinical Center, Banja Luka, Republic of Srpska, Bosnia and Herzegovina

specijalista otorinolaringolog

Vesna Tomić-Spirić, Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

Doc,dr.Specijalista interne medicine , subspecijalista alergolog

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