Heidelberg Retina Tomography II parameters in evaluating high- and normal-pressure glaucoma progression

Dušica Risović; Ranko Gvozdenović; Ivan Marjanović; Zihret Abazi; Miroslav Stamenković

doi:10.2298/3113

Dušica Risović Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Eye Clinic, Medical Center Zvezdara, Belgrade, Serbia
Ranko Gvozdenović Ophthalmology Clinic “Perfect Vison”, Subotica, Serbia
Ivan Marjanović Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Institute of Ophthalmology, Clinical Center of Serbia, Belgrade, Serbia
Zihret Abazi Eye Clinic, Medical Center Zvezdara, Belgrade, Serbia
Miroslav Stamenković Eye Clinic, Medical Center Zvezdara, Belgrade, Serbia

DOI: https://doi.org/10.2298/3113

Keywords: glaucoma, retina, tomography, disease progression,

Abstract

Background/Aim. Heidelberg retina tomography II (HRT II) haves been employed to quantitatively assess the topography of optic discs in eyes with high-pressure glaucoma (HPG) and normal-pressure glaucoma (NPG), in order to determine which of global and segmental optic disc parameters will prove to be most suitable for monitoring the progression of these two conditions. Methods. The results of 73 eyes of 73 patients with HPG and NPG were analyzed in relation to age, refractive error, quality of HRT images and stereometric parameters. Results. A statistically significant difference (p < 0.05) between the global baseline and follow-up results was found in: rim volume, maximum cup depth and cup shape measure (in the HPG group), and C/D ratio, cup volume, rim volume and cup shape measure (in the NPG group). The baseline and follow-up results of the retinal nerve fiber layer in the temporal and inferotemporal sectors show a significant difference in both groups. Conclusion. Several HRT stereometric parameters are useful for monitoring the progression of changes of the optic disc and local retina in eyes with HPG and NPG. Both segmental and global scanning is of importance in glaucoma progression analysis.

Author Biography

Dušica Risović, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Eye Clinic, Medical Center Zvezdara, Belgrade, Serbia

Doktor Medicine

References

Zeyen TG, Caprioli J. Progression of disc and field damage in early glaucoma. Arch Ophthalmol 1993; 111(1): 62−5.

Harwerth RS, Carter-Dawson L, Smith EL, Barnes G, Holt WF, Crawford MLJ. Neural losses correlated with visual losses in clinical perimetry. Invest Ophthalmol Vis Sci 2004; 45(9): 3152−60.

Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mit-chell RS. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci 2000; 41(3): 741−8.

Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol 1989; 107(5): 453−64.

Quigley HA, Katz J, Derick RJ, Gilbert D, Sommer A. An evalua-tion of optic disc and nerve fiber layer examinations in moni-toring progression of early glaucoma damage. Ophthalmology 1992; 99(1): 19−28.

Marković V, Kontić Đ, Hentova-Senćanić P, Božić M, Marjanović I, Krstić V, et al. Contribution and significance of Heidelberg Re-tinal Tomography II in diagnostics of ocular hypertension and its conversion into primary open-angle glaucoma. Vojnosanit Pregl 2009; 66(4): 283−9.

Mardin CY, Junemann AG. The diagnostic value of optic nerve imaging in early glaucoma. Curr Opin Ophthalmol 2001; 12(2): 100−4.

Badalà F, Nouri-Mahdavi K, Raoof DA, Leeprechanon N, Law SK, Caprioli J. Optic disk and nerve fiber layer imaging to detect glaucoma. Am J Ophthalmol 2007; 144(5): 724−32.

Wasyluk JT, Jankowska-Lech I, Terelak-Borys B, Grabska-Liberek I. Comparative study of the retinal nerve fibre layer thickness performed with optical coherence tomography and GDx scanning laser polarimetry in patients with primary open-angle glaucoma. Med Sci Monit 2012; 18(3): CR195−9.

Naithani P, Ramanjit S, Parul S, Tanuj D, Viney G, Dimple K. Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma. Invest Ophthalmol Vis Sci 2007; 48(7): 3138−45.

Mikelberg FS, Parfitt CM, Swindale NV, Graham SL, Drance SM, Gosine R. Ability of the heidelberg retina tomograph to detect early glaucomatous visual field loss. J Glaucoma 1995; 4(4): 242−7.

Iester M, Mikelberg FS, Drance SM. The effect of optic disc size on diagnostic precision with the Heidelberg retina tomograph. Ophthalmology 1997; 104(3): 545−8.

Wollstein G, Garway DF, Hitchings RA. Identification of early glaucoma cases with the scanning laser ophthalmoscope. Ophthalmology 1998; 105(8): 1557−63.

Europ Glaucoma Society. Terminology and guidelines for glau-coma. Italy, Pavona: Savona; 2008.

Zangwill LM, Jain S, Racette L, Ernstrom KB, Bowd C, Medeiros FA, et al. The effect of disc size and severity of disease on the diagnostic accuracy of the Heidelberg retina tomograph glau-coma probability score. Invest Ophthalmol Vis Sci 2007; 48(6): 2653−60.

Cioffi GA, Robin AL, Eastman RD, Perell HF, Sarfarazi FA, Kel-man SE. Confocal laser scanning ophthalmoscope: reproduci-bility of optic nerve head topographic measurements with the confocal scanning laser ophthalmoscope. Ophthalmology 1993; 100(1): 57−62.

Armaly MF. The correlation between appearance of the optic cup and visual function. Trans Am Acad Ophhtalmol Otola-ryngol 1969; 73(5): 898−913.

Kirsch RE, Anderson DR. Indetification og the glaucomatous disc. Trans Am Acad Ophhtalmol Otolaryngol 1973; 77(2): OP143−56.

Dreher AW, Tso PC, Weinreb RN. Reproducibility of topograph-ic measurements of the normal and glaucomatous optic nerve head with the laser tomographic scanner. Am J Ophthalmol 1991; 111(2): 221−9.

Tan JCH, Garway DF, Hitchings RA. Variability across the optic nerve head in scanning laser tomography. Br J Ophthalmol 2003; 87(5): 557−9.

Marjanovic I, Kontic D, Hentova-Sencanic P, Markovic V, Bozic M, Milic N. Topographic changes at the optic disc in 33 patients with primary open angle glaucoma. Int J Ophthalmol 2009; 2(4): 355−8.

Teal PK, Morin JD, McCulloch C. Assessment of the normal disc. Trans Am Ophhtalmol Soc 1972; 70: 164−77.

Tuulonen A, Airaksinen PJ. Initial glaucomatous optic disk and retinal nerve fibre layer abnormalities and their progression. Am J Ophthalmol 1991; 111(4): 485−90.

Varma R, Quigley HA, Pease ME. Changes in optic disk charac-teristics and number of nerve fibres in experimental glaucoma. Am J Ophthalmol 1992; 114(5): 554−9.

Uchida H, Brigatti L, Caprioli J. Detection of structural damage from glaucoma with confocal laser image analysis. Invest Ophthalmol Vis Sci 1996; 37(12): 2393−401.