Highly selective vagotomy and gastrojejunostomy in the treatment of peptic ulcer induced gastric outlet obstruction

  • Nebojša Radovanović Clinic for Digestive Disease – The First Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Aleksandar Simić Clinic for Digestive Disease – The First Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Ognjan Skrobić Clinic for Digestive Disease – The First Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia
  • Milutin Kotarac Clinic for Digestive Disease – The First Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia
  • Nenad Ivanović Clinic for Digestive Disease – The First Surgical Clinic, Clinical Center of Serbia, Belgrade, Serbia
Keywords: peptic ulcer, pyloric stenosis, vagotomy, proximal gastric, digestive system surgical procedures, treatment outcome,

Abstract


Background/Aim. The incidence of peptic ulcer-induced gastric outlet obstruction is constantly declining. The aim of this study was to present our results in the treatment of gastric outlet obstruction with highly selective vagotomy and gastrojejunostomy. Methods. This retrospective clinical study included 13 patients with peptic ulcer – induced gastric outlet obstruction operated with higly selective vagotomy and gastrojejunostomy. A 3-year follow-up was conducted including clinical interview and upper gastrointestinal endoscopy on 1 and 3 years after the surgery. Results. The most common preoperative symptom was vomiting (in 92.3% of patients). The mean preoperative body mass index was 16.3 ± 3.1 kg/m2, with 9 patients classified preoperatively as underweight. There were no intraoperative complications, nor mortality. At a 3-year follow-up there was no ulcer recurrence. Delayed gastric emptying was present in 1, bile reflux in 2, and erosive gastritis in 1 patient. Two patients suffered from mild “dumping” syndrome. Conclusion. Higly selective vagotomy combined with gastrojejunostomy is a safe and easily feasible surgical solution of gastric outlet obstruction induced by peptic ulcer. Good functional results and low rate of complications can be expected at a long-term follow-up.

References

Schwesinger WH, Page CP, Sirinek KR, Gaskill HV, Melnick G, Strodel WE. Operations for peptic ulcer disease: paradigm lost. J Gastrointest Surg 2001; 5(4): 438−43.

Chung SC, Li AK. Helicobacter pylori and peptic ulcer surgery. Br J Surg 1997; 84(11): 1489−90.

Ellis H. Pyloric stenosis complicating duodenal ulceration. World J Surg 1987; 11(3): 315−8.

Behrman SW. Management of complicated peptic ulcer disease. Arch Surg 2005; 140(2): 201−8.

Barksdale AR, Schwartz RW. The evolving management of gas-tric outlet obstruction from peptic ulcer disease. Curr Surg 2002; 59(4): 404−9.

Khullar SK, DiSario JA. Gastric outlet obstruction. Gastrointest Endosc Clin North Am 1996; 6: 585−603.

Chowdhury A, Dhali GK, Banerjee PK. Etiology of gastric outlet obstruction. Am J Gastroenterol 1996; 91(8): 1679.

Awan A, Johnston DE, Jamal MM. Gastric outlet obstruction with benign endoscopic biopsy should be further explored for malignancy. Gastrointest Endosc 1998; 48(5): 497−500.

Lau JY, Chung SC, Sung JJ, Chan AC, Ng EK, Suen RC, et al. Through-the-scope balloon dilation for pyloric stenosis: long-term results. Gastrointest Endosc 1996; 43(2 Pt 1): 98−101.

Kuwada SK, Alexander GL. Long-term outcome of endoscopic dilation of nonmalignant pyloric stenosis. Gastrointest Endosc 1995; 41(1): 15−7.

Lam Y, Lau JY, Law KB, Sung JJ, Chung SS. Endoscopic balloon dilation and Helicobacter pylori eradication in the treatment of gastric outlet obstruction. Gastrointest Endosc 1997; 46(4): 379−80.

Dragstedt LR, Owens FM. Supradiaphragmatic section of the va-gus nerves in the treatment of duodenal ulcer. Proc Soc Exp Biol (NY) 1943; 53: 152−4.

Mistiaen W, van Hee R, Bortier H. Current status of proximal gastric vagotomy, one hundred years after Pavlov: is it finally history. Acta Chir Belg 2005; 105(2): 121−6.

Griffith CA, Harkins HN. Partial gastric vagotomy: an experi-mental study. Gastroenterology 1957; 32(1): 96−102.

Amdrup E, Jensen HE. Selective vagotomy of the parietal cell mass preserving innervation of the undrained antrum. A pre-liminary report of results in patients with duodenal ulcer. Gas-troenterology 1970; 59(4): 522−7.

Debas HT. Peripheral regulation of gastric acid secretion. In: Johnson LR, editor. Physiology of digestive tract. New York: Raven Press; 1987. p. 931.

Donahue PE, Griffith C, Richter HM. A 50-year perspective upon selective gastric vagotomy. Am J Surg 1996; 172(1): 9−12.

Donahue PE. Highly selective vagotomy. Operat Techniq Gen Surg 2003; 5(2): 101−5.

Gibson JB, Behrman SW, Fabian TC, Britt LG. Gastric outlet ob-struction resulting from peptic ulcer disease requiring surgical intervention is infrequently associated with Helicobacter pylori infection. J Am Coll Surg 2000; 191(1): 32−7.

Csendes A, Maluenda F, Braghetto I, Schutte H, Burdiles P, Diaz JC. Prospective randomized study comparing three surgical tech-niques for the treatment of gastric outlet obstruction second-ary to duodenal ulcer. Am J Surg 1993; 166(1): 45−9.

Published
2015/04/24
Section
Original Paper