Lip, oral cavity and pharyngeal cancers in the population of the city of Belgrade in the period 1999–2010

Goran Videnović; Danijela Ilić; Dragan Miljuš; Dragan Krasić; Zoran Vlahović; Snežana Živković; Aleksandar Pavlović

doi:10.2298/7117

Goran Videnović Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
Danijela Ilić Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
Dragan Miljuš Cancer Registry of Serbia, Department for Prevention and Control of Noncommunicable Diseases, Institute of Public Health of Serbia “Dr Milan Jovanović – Batut”, Belgrade, Serbia
Dragan Krasić Faculty of Medicine, University of Niš, Niš, Serbia
Zoran Vlahović Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia
Snežana Živković Cancer Registry of Serbia, Department for Prevention and Control of Noncommunicable Diseases, Institute of Public Health of Serbia “Dr Milan Jovanović – Batut”, Belgrade, Serbia
Aleksandar Pavlović Faculty of Medicine, University of Kosovska Mitrovica, Kosovska Mitrovica, Serbia

DOI: https://doi.org/10.2298/7117

Keywords: lip neoplasms, mouth neoplasms, pharyngeal neoplasms, incidence, risk factors, sex, age groups,

Abstract

Background/Aim. Cancers of the lip, oral cavity and pharynx (LOCP) are frequently grouped together mainly because they have similar risk factors. The incidence rate of these cancers varies worldwide depending on the geographic location. The aim of this study was to determine trends in age-standardized incidence rates of LOCP cancers in the Belgrade population during a 12-year period, from 1999 to 2010. Methods. From The Serbian Cancer Registry (The Registry), we extracted all cases of LOCP cancers registered in Belgrade from January 1, 1999 to December 31, 2010. Joinpoint regression analysis was used to define trends and annual percentage change (APC). Results. A total number of 2,025 (1,509 in men and 516 in women) LOCP cancers were reported to the Registry during the study period. The age standardized rate (ASR) for the entire period and for all LOCP cancers, was 6.24 per 100,000 persons (10.35 for men and 2.86 for women). ASR for lip cancers decreased (p < 0.001) during the study period with APC of -8.4%. The ASR for oral cavity and pharyngeal cancers increased (p < 0.05). Conclusion. Our results show a significantly decreasing trend of the incidence rate for lip cancers in the population of the city of Belgrade between 1999 and 2010. On the contrary, the incidence of oral cavity and pharyngeal cancers increased for both men and women.

References

World Health Organization. Malignant neoplasms of lip, oral cavity and pharynx (C00-C14); ICD 10. Geneva: World Health Organization; 2010.

Warnakulasuriya S. Causes of oral cancer-an appraisal of controversies. Br Dent J 2009; 207(10): 471−5.

Warnakulasuriya S. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncol 2010; 46(6): 407−10.

Mihajlović J, Pechlivanoglou P, Miladinov-Mikov M, Živković S, Postma MJ. Cancer incidence and mortality in Serbia 1999–2009. BMC Cancer 2013; 13(1): 2−11.

Maruccia M, Onesti MG, Parisi P, Cigna E, Troccola A, Scuderi N. Lip cancer: a 10-year retrospective epidemiological study. Anticancer Res 2012; 32(4): 1543−6.

Czerninski R, Zini A, Sgan-Cohen HD. Lip cancer: incidence, trends, histology and survival: 1970-2006. Br J Dermatol 2010; 162(5): 1103−9.

Cankaya H, Garca MF, Bozan N, Isik D, Kiroglu AF. Epidemiological features of the lip cancers and it's relation with smoking. East J Med 2013; 18(2): 64−7.

Radoï L, Paget-Bailly S, Cyr D, Papadopoulos A, Guida F, Schmaus A, et al. Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case-control study, the ICARE study. Eur J Cancer Preven 2013; 22(3): 268−76.

O'Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA. Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis. Oral Oncol 2012; 48(12): 1191−201.

Michelle L, Stock ML, Peterson LM, Houlihan AE, Walsh LA. Influence of Oral Sex and Oral Cancer Information on Young Adults' Oral Sexual-Risk Cognitions and Likelihood of HPV Vaccination. J Sex Res 2013; 50(1): 95−102.

Hocking JS, Stein A, Conway EL, Regan D, Grulich A, Law M, et al. Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers. Br J Cancer 2011; 104(5): 886−91.

Blomberg M, Nielsen A, Munk C, Kjaer SK. Trends in head and neck cancer incidence in Denmark, 1978-2007: focus on human papillomavirus asso-ciated sites. Int J Cancer 2011; 129(3): 733−41.

Auluck A, Walker B, Hislop G, Lear SA, Schuurman N, Rosin M. Population-based incidence trends of oropharyngeal and oral cavity cancers by sex among the poorest and underprivileged populations. BMC Cancer 2014; 14(1): 316.

Warnakulasuriya S. Significant oral cancer risk associated with low so-cioeconomic status. Evid Based Dent 2009; 10(1): 4−5.

Al-Dakkak I. Socioeconomic status and head and neck cancer. Evid Based Dent 2010; 11(2): 57−8.

Conway DI, McKinney PA, McMahon AD, Ahrens W, Schmeisser N, Benhamou S, et al. Socioeconomic factors associated with risk of upper aerodigestive tract cancer in Europe. Eur J Cancer 2010; 46(3): 588−98.

Jovic N, Magić Z. The clinical significance of genetic and epigenetic changes in oral carcinomas. Belgrade: Akademija medicinskih nauka Srpskog lekarskog društva; 2013. (Serbian)

World Health Organization. International Classification of Diseases for Oncology, (ICD-O-3). 3rd ed. Geneva: World Health Organization; 2000.

Jensen OM, Parkin DM, Maclennan R, Muir CS, Skeet RG. Cancer Registration: Principles and Methods. Lyon: International Agency for Research on Cancer; 1991.

Doobaree IU, Landis SH, Linklater KM, El-Hariry I, Moller H, Tyczynski J. Head and neck cancer in South East England between 1995-1999 and 2000-2004: An estimation of incidence and distribution by site, stage and histological type. Oral Oncol 2009; 45(9): 809−14.

Braakhuis BJM, Leemans C, Visser O. Incidence and survival trends of head and neck squamous cell carcinoma in the Netherlands between 1989 and 2011. Oral Oncol 2014; 50(7): 670−5.

Chen K, Song F, He M, Li H, Qian B, Zhang W, el. Trends in head and neck cancer incidence in Tianjin, China, between 1981 and 2002. Head Neck 2009; 31(2): 175−82.

Hilly O, Shkedy Y, Hod R, Soudry E, Mizrachi A, Hamzany Y, et al. Carcinoma of the oral tongue in patients younger than 30 years: comparison with patients older than 60 years. Oral Oncol 2013; 49(10): 987−90.

Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T, et al. Increasing Incidence of Oral Tongue Squamous Cell Carcinoma in Young White Women, Age 18 to 44 Years. J Clin Oncol 2011; 29(11): 1488−94.

Zini A, Czerninski R, Sgan-Cohen HD. Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites. J Oral Pathol Med 2010; 39(4): 299−305.

Ariyawardana A, Johnson NW. Trends of lip, oral cavity and oropharyngeal cancers in Australia 1982–2008: overall good news but with rising rates in the oropharynx. BMC Cancer 2013; 13(1): 333.

Monteiro LS, Antunes L, Bento MJ, Warnakulasuriya S. Incidence rates and trends of lip, oral and oro-pharyngeal cancers in Portugal. J Oral Pathol Med 2012; 42(4): 345−51.

Alho OP, Keränen MR, Kantola S, Riihimäki S, Jokinen K, Alho P, et al. Lip cancer in Northern Finland: changing incidence and clinical characteristics. J Oral Pathol Med 2000; 29(7): 299−302.

Institute of Public Health of Serbia „Dr Milan Jovanović Batut”. Health of Population of Serbia. Analytical Study 1997–2007. Life Styles: Smoking. Belgrade. Institute of Public Health of Serbia „Dr Milan Jovanović Batut”; 2009. (Serbian)

Ministry of Health of Republic of Serbia. National Health Survey 2006. Key Findings. 2007. [cited 2014 Nov 3]. Available from: http://www.batut.org.rs/index.php

Mork J, Møller B, Dahl T, Bray F. Time trends in pharyngeal cancer incidence in Norway 1981-2005: a subsite analysis based on a reabstraction and recoding of registered cases. Cancer Causes Control 2010; 21(9): 1397−405.

Guntinas-Lichius O, Wendt T, Buentzel J, Esser D, Lochner P, Mueller A, et al. Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database. J Cancer Res Clin Oncol 2010; 136(1): 55−63.

Hwang E, Johnson-Obaseki S, McDonald JT, Connell C, Corsten M. Incidence of head and neck cancer and socioeconomic status in Canada from 1992 to 2007. Oral Oncol 2013; 49(11): 1072−6.

Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol 2014; 50(5): 387−403.

Radoï L, Luce D. A review of risk factors for oral cavity cancer: the importance of a standardized case definition. Community Dent Oral Epi-demiol 2013; 41(2): 97−109.

Conway DI, McMahon AD, Smith K, Black R, Robertson G, Devine J, et al. Components of socioeconomic risk associated with head and neck can-cer: a population-based case-control study in Scotland. Br J Oral Maxillofac Surg 2010; 48(1): 11−7.

World Health Organization. Global status reports on alcohol and health. 2014. [cited 2014 Nov 1]. Available from: http://www.who.int/substance_abuse/ publications/global_ alco-hol_report/profiles/srb.pdf

Hemminki K, Dong C, Frisch M. Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. Eur J Cancer Prev 2000; 9(6): 433−7.