Biometric features of the eyes of preterm born babies
Abstract
Background/Aim. Preterm birth and retinopathy of prematurity (ROP) could affect optical and biometric features of eyes and cause refractive errors. The aim of this study was to compare the ocular axial length, anterior chamber depth and lens thickness changes during the first year in preterm born babies with and without ROP. Methods. This prospective longitudinal study included 87 preterm born babies. The examinations were performed at 3 and 12 months after birth and included fundus examination and measurements of the ocular axial length, anterior chamber depth and lens thickness. Based on the results of fundus examination at 3 months, the subjects were divided into two groups and the measurements of those with and without ROP were compared. Results. At 3 months 60.92% of infants had ROP. The mean values in the ROP group were: axial length 16.56 mm and 16.53 mm, chamber depth 2.34 mm and 2.38 mm and lens thickness 4.04 mm and 3.96 mm, in the right and the left eye, respectively. In the no ROP group these values were: axial length 17.06 mm and 17.08 mm, chamber depth 2.31mm and 2.39 mm and lens thickness 4.16 mm and 4.14 mm in the right and the left eye, respectively. At 12 months 28.74% of the children had a change in the ocular fundus as a result of the ROP therapy. In the ROP group the axial length was 19.94 mm in both eyes, chamber depth 3.01 mm and 2.99 mm and lens thickness 4.28 mm and 4.29 mm, in the right and the left eye, respectively. In the no ROP group the axial length was 20.64 mm and 20.29 mm, lens thickness 4.37 mm and 4.36 mm, in the right and the left eye, respectively and chamber depth 3.10 mm in both eyes. Conclusion. In the group of children with ROP axial length of the eye at 3 and 12 months was statistically significantly smaller in comparison to the group without ROP. Statistically significant difference was not found between these groups in the anterior chamber depth and lens thickness
References
Birch EE, O'Connor AR. Preterm birth and visual development. Semin Neonatol 2001; 6(6): 487−97.
Oros A. Modern approach to the development of the retina in premature infants. In: Dedović Bjelajac B, Kostić Todorović M, Marković M, Mileusnić Milenović R, Mušić Trninić N, Oros A, et al, editors. Clinical seminars. Belgrade: Institute for neonatology; 2013. p. 119−27. (Serbian)
Madan A, Jan JE, Good WV. Visual development in preterm infants. Dev Med Child Neurol 2005; 47(4): 276−80.
van Sorge AJ, Schalij-Delfos NE, Kerkhoff FT, van Rijn LJ, van Hillegersberg JL, van Liempt IL, et al. Reduction in screening for retinopathy of prematurity through risk factor adjusted inclusion criteria. Br J Ophthalmol 2013; 97(9): 1143−7.
Oros A. Detection, treatment and prevention of the development of retinopathy of prematurity [thesis]. Novi Sad: Faculty of Medicine University of Novi Sad; 2002. (Serbian)
Budd SJ, Hartnet ME. Increased angiogenic factors associated with peripheral avascular retina and intravitreous neovascularization: a model of retinopathy of prematurity. Arch Ophthalmol 2010; 128(5): 589−95.
Oros A. Etiology and pathogenesis of retinopathy of prematurity. In: Oros A, editor. Retinopathy of prematurity. Belgrade: Zadužbina Andrejević; 2003. p. 22−54. (Serbian)
Fielder AR, Reynolds JD. Retinopathy of prematurity: clinical aspects. Semin Neonatol 2001; 6(6): 461−75.
Pierce LM, Raab EL, Holzman IR, Ginsburg RN, Brodie SE, Stroustrup A. Importance of birth weight as a risk factor for severe retinopathy of prematurity when gestational age is 30 or more weeks. Am J Ophthalmol 2014; 157(6): 1227−30.e2.
Fierson WM. American Academy of Pediatrics Section on Ophthalmology; American Academy of Ophthalmology; American Association for Pediatric Ophthalmology and Strabismus; American Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 2013; 131(1): 189−95.
Fielder AR, Levene MI. Screening for retinopathy of prematurity. Arch Dis Child 1992; 67 (7 Spec No): 860−7.
Kennedy KA, Wrage LA, Higgins RD, Finer NN, Carlo WA, Walsh MC, et al. Evaluating etinopathy of prematurity screening guidelines for 24-27 week gestational age infants. J Perinatol 2014; 34(4): 311−8.
Demorest BH. Retinopathy of prematurity requires diligent follow-p care. Surv Ophthalmol 1996; 41(2): 175−8.
Saunders KJ, McCulloch DL, Shepherd AJ, Wilkinson AG. Emmetropisation following preterm birth. Br J Ophthalmol 2002; 86(9): 1035−40.
Hsieh CJ, Liu JW, Huang JS, Lin KC. Refractive outcome of premature infants with or without retinopathy of prematurity at 2 years of age: A prospective controlled cohort study. Koahsinug J Med Sci 2012; 28(4): 204−11.
Siegwart JT Jr, Norton TT. Perspective: how might emmetropization and genetic factors produce myopia in normal eyes? Optom Vis Sci 2011; 88(3): E365−72.
Troilo D, Wallman J. The regulation of eye gowth and refractive state: an experimental study of emmetropization. Vision Res 1991; 31(7−8): 1237−50.
Mutti DO, Mitchell GL, Jones LA, Friedman NE, Frane SL, Lin WK, et al. Axial growth and changes in lenticular and corneal power during emmetropization in infants. Invest Ophthalmol Vis Sci 2005; 46(9): 3074−80.
Cosgrave E, Scott C, Goble R. Ocular findings in low birthweight and premature babies in the first year: Do we need to screen? Eur J Ophthalmol 2008; 18(1): 104−11.
Mutti DO, Hayes JR, Mitchell GL, Jones LA, Moeschberger ML, Cotter SA, et al. Refractive error, axial length, and relative peripheral refractive error before and after the onset of myopia. Invest Ophthalmol Vis Sci 2007; 48: 2510−9.
Choi MY, Park IK, Yu YS. Long term refractive outcome in eyes of preterm infants with and without retinopathy of prematurity: comparison of keratometric value, axial length, anterior chamber depth, and lens thicknes. Br J Ophthalmol 2000; 84(2): 138−43.
Chen TC, Tsai TH, Shih YF, Yeh PT, Yang CH, Hu FC, et al. Long–term Evaluation of Refractive Status and Optical Components in Eyes of Children Born Prematurely. Invest Ophthalmol Vis Sci 2010; 51(12): 6140−8.
Cook A, White S, Batterbury M, Clark D. Ocular growth and refractive error development in premature infants with or without retinopathy of prematurity. Invest Ophthalmol Vis Sci 2008; 49(12): 5199−207.
O'Brien C, Clark D. Ocular biometry in pre-term infants without retinopathy of prematurity. Eye (Lond) 1994; 8( Pt 6): 662−5.
Laws DE, Haslett R, Ashby D, O'Brien C, Clark D. Axial length biometry in infants with retinopathy of prematurity. Eye (Lond) 1994; 8( Pt 4): 427−30.
McColm JR, Fleck BW. Retinopathy of prematurity: causation. Semin Neonatol 2001; 6(6): 453−60.
Ho SF, Mathew MR, Wykes W, Lavy T, Marshall T. Retinopathy of prematurity: an optimum screening strategy. J AAPOS 2005; 9(6): 584−8.
Mathew MR, Fern AI, Hill R. Retinopathy of prematurity: are we screening too many babies? Eye (Lond) 2002;16(5): 538−42.
Shah PK, Ramakrishnan M, Sadat B, Bachu S, Narendran V, Kalpana N. Long term refractive and structural outcome following laser treatment for zone 1 aggressive posterior retinopathy of prematurity. Oman J Ophthalmol 2014; 7(3): 116−9
Fledelius HC, Fledelius C. Eye Size in Treshold Retinopathy of Prematurity, Based on a Danish Preterm Infant Series: Early Axial Eye Growth, Pre- and Postnatal Aspects. Invest Ophthalmol Vis Sci 2012; 53(7): 4177−84.
Pennie FC, Wood IC, Olsen C, White S, Charman WN. A longitudinal study of the biometric and refractive changes in full-term infants during the first year of life. Vision Res 2001; 41(21): 2799−810.
Wang J, Ren X, Shen L, Yanni SE, Leffler JN, Birch EE. Development of Refractive Error in Individual Children With Regressed Retinopathy of Prematurity. Invest Ophthalmol Vis Sci 2013; 54(9): 6018−24.