Skip to main content Skip to main navigation menu Skip to site footer

Vojnosanitetski pregled

Health-related quality of life in patients with functional dyspepsia

Miloš Bjelović University of Belgrade, Faculty of Medicine; Clinical Center of Serbia, University Hospital for Digestive Surgery, Belgrade, Serbia
Nemanja Zarić University Hospital for Digestive Surgery, Belgrade, Serbia
Tamara Babič University Hospital for Digestive Surgery, Belgrade, Serbia
Igor Dragičević Public Health Institute, Šabac, Serbia
Aleksandar Ćorac University of Priština/Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, Serbia
Goran Trajković University of Belgrade, Faculty of Medicine, Belgrade, Serbia

DOI: https://doi.org/10.2298/VSP151024294B

Keywords: dyspepsia, quality of life, depression, anxiety, surveys and questionnaires,

Abstract

Background/Aim. Recent population based studies have proved that patients with functional dyspepsia (FD) have a significantly impaired health-related quality of life HRQoL as compared to general population. The aim of the study was to evaluate the impact of FD on (HRQoL) in patients treated in primary healthcare settings in Serbia. Methods. The study involved 1,448 patients with FD. The diagnosis was made by a general practice physician or gastroenterologist using the Rome III diagnostic criteria. The Serbian version of the questionnaire for the assessment of HRQoL of the U.S. Department of Health and Human Services’ Centers for Disease Control and Prevention (HRQoL-4 item CDC) was used for data collection, while descriptive statistical measurements were applied to calculate standard deviation, frequency as well as multiple logistic regression model. Results. Out of the total number of patients, 41.8% assessed their health condition as seriously disordered or poor. The mean values of health disorder duration over the last 30 days was 11.8 days, disordered physical health 7.2 days, mental disorder 6.3 days, and activity limitation 5.1 days. Also, 29.7%, 15.2%, 12.8% and 10.7% of the patients reported ≥ 14 unhealthy days, ≥ 14 physically unhealthy days, ≥ 14 mentally unhealthy days and ≥ 14 activity limitation days, respectively. Conclusion. From patients’ perspective, FD has a significant impact on HRQoL. In this study, 41.8% of the patients described their health status as fair or poor, and FD significantly affects all aspects of life, both mental and physical. The recognition of that impact is probably the most important step towards appropriate treatment and decreasing HRQoL impairment in patients with FD.

Author Biographies

Miloš Bjelović, University of Belgrade, Faculty of Medicine; Clinical Center of Serbia, University Hospital for Digestive Surgery, Belgrade, Serbia

Local Ethics committee approved study methodology and conduction.

Nemanja Zarić, University Hospital for Digestive Surgery, Belgrade, Serbia

Local Ethics committee approved study methodology and conduction.

Tamara Babič, University Hospital for Digestive Surgery, Belgrade, Serbia

Local Ethics committee approved study methodology and conduction.

Igor Dragičević, Public Health Institute, Šabac, Serbia

Local Ethics committee approved study methodology and conduction.

Aleksandar Ćorac, University of Priština/Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, Serbia

Local Ethics committee approved study methodology and conduction.

Goran Trajković, University of Belgrade, Faculty of Medicine, Belgrade, Serbia

Local Ethics committee approved study methodology and conduction.

References

Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology 2006; 130(5): 1466−79.

Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006; 130(5): 1377−90.

Van Oudenhove L, Aziz Q. Recent insights on central processing and psychological processes in functional gastrointestinal disorders. Dig Liver Dis 2009; 41(11): 781−7.

Olafsdottir LB, Gudjonsson H, Jonsdottir HH, Thjodleifsson B. Natural history of functional dyspepsia: A 10-year population-based study. Digestion 2010; 81(1): 53−61.

Agreus L. Natural history of dyspepsia. Gut 2002; 50(Suppl 4): 2−9.

Ebling B, Jurcic D, Barac KM, Bilic A, Bajic I, Martinac M, et al. Influence of various factors on functional dyspepsia. Wien Klin Wochenschr 2016; 128(1−2): 34−41.

Talley NJ, Locke GR, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, et al. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut 2006; 55(7): 933−9.

Monés J, Adan A, Segú JL, López JS, Artés M, Guerrero T. Quality of life in functional dyspepsia. Dig Dis Sci 2002; 47(1): 20−6.

Aro P, Talley NJ, Agréus L, Johansson SE, Bolling-Sternevald E, Storskrubb T, et al. Functional dyspepsia impairs quality of life in the adult population. Aliment Pharmacol Ther 2011; 33(11): 1215−24.

Moriarty DG, Zack MM, Kobau R. The Centers for DiseaseCon-trol and Prevention's Healthy Days Measures - population-tracking of perceivedphysical and mental health overtime. Health Qual Life Outcomes 2003; 1(1): 37.

Bjelović M, Babić T, Dragicević I, Corac A, Goran Trajković. The Burden of Gastroesophageal Reflux Disease on Patients' Daily Lives: A Cross-Sectional Study Conducted in a Primary Care Setting in Serbia. Srp Arh Celok Lek 2015; 143(11−12): 676−80.

Mahadeva S, Goh KL. Anxiety, depression and quality of life dif-ferences between functional an organic dyspepsia. J Gastroen-terol Hepatol 2011; 26(Suppl 3): 49−52.

Pajala M, Heikkinen M, Hintikka J. Mental distress in patients with functional or organic dyspepsia: A comparative study with a sample of the general population. Aliment Pharmacol Ther 2005; 21(3): 277−81.

Choung RS, Talley NJ. Novel mechanisms in functional dyspep-sia. World J Gastroenterol 2006; 12(5): 673−7.

Internal Clinical Guidelines Team (UK). Dyspepsia and Gastro-Oesophageal Reflux Disease: Investigation and Management of Dyspepsia, Symptoms Suggestive of Gastro-Oesophageal Reflux Disease, or Both. London: National Institute for Health and Care Excellence (UK); 2014.

Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in func-tional dyspepsia. Gastroenterology 2001; 121(3): 526−35.

Huang Z, Yang X, Lan L, Liu T, Liu C, Li J, et al. Correlation between social factors and anxiety-depression in function dys-pepsia: do relationships exist. Prz Gastroenterol 2014; 9(6): 348−53.

Aro P, Talley NJ, Ronkainen J, Storskrubb T, Vieth M, Johansson S, et al. Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology 2009; 137(1): 94−100.

Published

2017/11/28

Issue

Vol. 74 No. 11 (2017)

Section

Original Paper

Close

Ensuring a Blind Peer Review

To ensure the integrity of the blind peer-review for submission to this journal, every effort should be made to prevent the identities of the authors and reviewers from being known to each other. This involves the authors, editors, and reviewers (who upload documents as part of their review) checking to see if the following steps have been taken with regard to the text and the file properties:

The authors of the document have deleted their names from the text, with Author and year used in the references and footnotes, instead of the authors' name, article title, etc.;
With Microsoft Office documents, author identification should also be removed from the properties for the file (see under File in Word), by clicking on the following, beginning with File on the main menu of the Microsoft application: File > Save As > Tools (or Options with a Mac) > Security > Remove personal information from file properties on save > Save.
With PDFs, the authors' names should also be removed from Document Properties found under File on Adobe Acrobat's main menu.