Pulmonary veins isolation in a patient with atrial fibrillation and pronounced vagal response: Is it enough?

  • Dragan Dinčić Clinic for Emergency Internal Medicine, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.
  • Ognjen Gudelj Clinic for Cardiology, Military Medical Academy, Belgrade, Serbia.
  • Ivica Djurić Clinic for Cardiology, Military Medical Academy, Belgrade, Serbia.
  • Milan Marinković Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia.
Keywords: atrial fibrillation, pulmonary veins, catheter ablation, vagotomy,

Abstract


 

Introduction. Pulmonary vein isolation (PVI) by antral circumferential ablation is the standard procedure for patients with symptomatic and drug-refractory paroxysmal atrial fibrillation (AF). In some patients addition of ganglionated plexi (GP) modification in anatomic locations to PVI confers significantly better outcomes than PVI alone. Case report. We reported a patient with paroxysmal, symptomatic AF and severe bradycardia a month prior to ablation. The patient was treated with antiarrhythmic drugs without success. Because of severe bradicardia the patient was implanted with a temporary pace maker two days before PVI. During PVI the decision was made to also do a modification of the left GP. Three months after the procedure the patients was in stable sinus rhythm without any symptoms. Conclusion. In selected patients with paroxysmal AF and pronounced vagal response PVI by circumferential antral ablation combined with GP modification during single ablation procedure can produce higher success rates than PVI or GP ablation alone.

Author Biography

Dragan Dinčić, Clinic for Emergency Internal Medicine, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia.

Prof. dr Dragan Dincic,

Zamenik na;elnika VMA

References

Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommen-dations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and re-search trial design. Europace 2012; 14: 528–606.

Chen PS, Chen LS, Fishbein MC, Lin SF, Nattel S. Role of the autonomic nervous system in atrial fibrillation: pathophysiolo-gy and therapy. Circ Res 2014; 114(9): 1500−15.

Linz D, Ukena C, Mahfoud F, Neuberger HR, Böhm M. Atrial au-tonomic innervation: a target for interventional antiarrhythmic therapy? J Am Coll Cardiol 2014; 63(3): 215−24.

Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, et al. Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation 2004; 109(3): 327−34.

Po SS, Nakagawa H, Jackman WM. Localization of left atrial ganglionated plexi in patients with atrial fibrillation. J Cardio-vasc Electrophysiol 2009; 20(10): 1186−9.

Verma A, Saliba WI, Lakkireddy D, Burkhardt JD, Cummings JE, Wazni OM, et al. Vagal responses induced by endocardial left atrial autonomic ganglion stimulation before and after pulmonary vein antrum isolation for atrial fibrillation. Heart Rhythm 2007; 4(9): 1177–82.

Katritsis D, Giazitzoglou E, Sougiannis D, Goumas N, Paxinos G, Camm AJ. Anatomic approach for ganglionic plexi ablation in patients with paroxysmal atrial fibrillation. Am J Cardiol 2008; 102(3): 330–4.

Danik S, Neuzil P, d’Avila A, Malchano ZJ, Kralovec S, Ruskin JN et al. Evaluation of catheter ablation of periatrial ganglionic plexi in patients with atrial fibrillation. Am J Cardiol 2008; 102(5): 578–83.

Pokushalov E, Romanov A, Artyomenko S, Turov A, Shirokova N, Katritsis DG. Left atrial ablation at the anatomic areas of gan-glionated plexi for paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 2010; 33(10): 1231−8.

Mikhaylov E, Kanidieva A, Sviridova N, Abramov M, Gureev S, Szili-Torok T, et al. Outcome of anatomic ganglionated plexi abla-tion to treat paroxysmal atrial fibrillation: a 3- year follow-up study. Europace 2011; 13(3): 362–70.

Calo L, Rebecchi M, Sciarra L, De Luca L, Fagagnini A, Zuccaro LM, et al. Catheter ablation of right atrial ganglionated plexi in patients with vagal paroxysmal atrial fibrillation. Circ Arrhythm Electrophysiol 2012; 5(1): 22–31.

Zhou Q, Hou Y, Yang S. A meta-analysis of the comparative ef-ficacy of ablation for atrial fibrillation with and without abla-tion of the ganglionated plexi. Pacing Clin Electrophysiol 2011; 34(12): 1687–94.

Pokushalov E, Romanov A, Shugayev P, Artyomenko S, Shirokova N, Turov A, et al. Selective ganglionated plexi ablation for parox-ysmal atrial fibrillation. Heart Rhythm 2009; 6(9): 1257–64.

Deshmukh AJ, Yao X, Schilz S, Van Houten H, Sangaralingham LR, Asirvatham SJ, et al. Pacemaker implantation after catheter ablation for atrial fibrillation. J Interv Card Electrophysiol 2016; 45(1): 99−105.

Katritsis DG, Pokushalov E, Romanov A, Giazitzoglou E, Siontis GC, Po SS, et al. Autonomic denervation added to pulmonary vein isolation for paroxysmalatrial fibrillation: a randomized clinical trial. J Am Coll Cardiol 2013; 62(24): 2318−25.

Osman F, Kundu S, Tuan J, Jeilan M, Stafford PJ, Ng GA. Gan-glionic plexus ablation during pulmonary vein isolation—predisposing to ventricular arrhythmias? Indian Pacing Elec-trophysiol J 2010; 10(2): 104−7.

Published
2017/07/05
Section
Case report