A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley

  • Milka Punoševac University of Belgrade – Faculty of Pharmacy, Department of Pharmacognosy
  • Jelena Radović University of Belgrade – Faculty of Pharmacy, Department of Pharmacognosy
  • Aleksandra Leković University of Belgrade – Faculty of Pharmacy, Department of Pharmacognosy
  • Tatjana Kundaković-Vasović University of Belgrade – Faculty of Pharmacy, Department of Pharmacognosy
Keywords: Petroselinum crispum, essential oil, flavonoids, antioxidants

Abstract


Parsley is a biennial aromatic plant from the Apiaceae family, which is characterized by an unbranched root, pinnately divided leaves, umbels and schizocarp. It contains essential oil in all parts, with phenylpropane and terpene compounds as main components. It is rich in flavonoids and other polyphenolic compounds, containing furanocoumarins, carotenoids, polyacetylenes, and its leaves are a source of vitamins and minerals. The chemical composition of parsley depends on a number of factors, so it differs not only in different parts and varieties of the plant, but also in different samples of the same parts of one variety. The most important parsley compounds are myristicin, apiol, 1-allyl-2,3,4,5-tetramethoxybenzene, β-phellandrene, 1,3,8-p-menthatriene, β-pinene, terpinolene, apiin, oxypeucedanin and falcarinol. Parsley has a long tradition of use in the treatment of urinary tract disorders, and modern in vitro and in vivo studies reveal numerous effects of various parsley preparations such as diuretic, antiurolithiasis, hypouricemic, hypolipidemic, hypoglycemic, hypotensive, antioxidant, anti-inflammatory and antiplatelet effect. Today, apart from its medical application, parsley is one of the most commonly used culinary herbs.

References

Teuscher E, Bauermann U, Werner M. Medicinal spices: A Handbook of Culinary Herbs, Spices, Spice Mixtures and Their Essential Oils. Florida: Medpharm Scientific Publishers, Stuttgart, CRC Press, Taylor and Francis Group; 2006. 460 p.

Evans WC. Trease and Evans Pharmacognosy. 16th ed. Saunders Elsevier; 2009. 603 p.

Nikolić V. Familija Apiaceae L. In: Josifović M, editor. Flora SR Srbije V. Beograd: Srpska akademija nauka i umetnosti; 1973; p. 183-9.

Jančić R, Lakušić B. Botanika farmaceutika, 6th ed. Beograd: Lento; 2017. 293 p.

Craft JD, Setzer WN. The volatile components of parsley, Petroselinum crispum (Mill.) Fuss. Am J Essent Oil Nat Prod. 2017;5(1):27-32.

Kovačević N. Osnovi farmakognozije, 3rd ed. Beograd: Srpska školska knjiga; 2004. 408 p.

Heber D. PDR for Herbal Medicines, 4th ed. Thomson Healthcare Inc.; 2007. 1026 p.

Wichtl M. Teedrogen und Phytopharmaka Ein Handbuch fur die Praxis auf wissenschaftlicher Grundlage. 4th ed. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2002. 441-8 p.

Farzaei MH, Abbasabadi Z, Ardekani MRS, Rahimi R, Farzaei F. Parsley: a review of ethnopharmacology, phytochemistry and biological activities. J Tradit Chin Med. 2013;33(6):815–26.

Marín I, Sayas-Barberá E, Viuda-Martos M, Navarro C, Sendra E. Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oils from Organic Fennel, Parsley, and Lavender from Spain. Foods. 2016;5:18.

Jugreeta BS, Mahomoodally MF. Essential oils from 9 exotic and endemic medicinal plants from Mauritius shows in vitro antibacterial and antibiotic potentiating activities. S Afr J Bot. 2020;132:355-62.

Christensen LP. Aliphatic C17-Polyacetylenes of the Falcarinol Type as Potential Health Promoting Compounds in Food Plants of the Apiaceae Family. Recent Pat Food Nutr Agric. 2011;3:64-77.

Fernandes A, Polyzos N, Petropoulos SA, Pinela J, Ardohain E, Moreira G et al. Phytochemical Composition and Nutritional Value of Pot-Grown Turnip-Rooted and Plain and Curly-Leafed Parsley Cultivars. Agronomy. 2020;10:1416-15.

Al-Yousofy F, Gumaih H, Ibrahim H, Alasbahy A. Parsley! Mechanism as antiurolithiasis remedy. Am J Clin Exp Urol. 2017;5(3):55-62.

Hozayen, WG, El-Desouky MA, Soliman HA, Ahmed RR, Khaliefa AK. Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats. BMC Comp Alt Med. 2016;16:165.

Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM et al. Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms. Int J Mol Sci. 2018;19:765.

Epifanio NMM, Cavalcanti LRI, Santos KF, Duarte PSC, Kachlicki P, Ożarowski M et al. Chemical characterization and in vivo antioxidant activity of parsley (Petroselinum crispum) aqueous extract. Food Funct. 2020;11:5346–56.

El Rabey HA, Al-Seeni MN, Al-Ghamdi HB. Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats. BioMed Res Int. doi: 10.1155/2017/3098745.

Kreydiyyeh SI, Usta J. Diuretic effect and mechanism of action of parsley. J Ethnopharmacol. 2002;79:353-7.

Alexander SPH. Flavonoids as antagonists at A1 adenosine receptors. Phytother Res. 2006;20:1009-12.

Moazedi AA, Mirzaie DN, Seyyednejad SM, Zadkarami MR, Amirzargar A. Spasmolytic effect of Petroselinum crispum (Parsley) on rat's ileum at different calcium chloride concentrations. Pak J Biol Sci. 2007;10(22):4036-42.

Branković S, Kitić D, Radenković M, Ivetić V, Veljković S, Nešić M. Relaxant activity of aqueous and ethanol extracts of parsley (Petroselinum crispum (Mill) Nym. ex A. W Hill, Apiaceae) on isolated ileum of rat. Med Pregl. 2010;63(7-8):475-8.

Soliman MM, Nassan MA, Aldhahrani A, Althobaiti F, Mohamed WA. Molecular and Histopathological Study on the Ameliorative Impacts of Petroselinum crispum and Apium graveolens against Experimental Hyperuricemia. Sci Rep. 2020;10:9512.

Zhang H, Chen F, Wang X, Yao HY. Evaluation of antioxidant activity of parsley (Petroselinum crispum) essential oil and identification of its antioxidant constituents. Food Res Int. 2006;39(8):833-9.

Popović M., Kaurinović B, Jakovljević V, Mimica‐Dukic N, Bursać M. Effect of parsley (Petroselinum crispum (Mill.) Nym. ex A.W. Hill, Apiaceae) extracts on some biochemical parameters of oxidative stress in mice treated with CCl4. Phytother Res. 2007;21:717-23.

Fejes S, Blázovics A, Lemberkovics E, Petri G, Szoke E, Kéry A. Free radical scavenging and membrane protective effects of methanol extracts from Anthriscus cerefolium L. (Hoffm.) and Petroselinum crispum (Mill.) nym. ex A.W. Hill. Phytother Res. 2000;14(5):362-5.

Nielsen SE, Young JF, Daneshvar B, Lauridsen ST, Knuthsen P, Sandström B et al. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. Br J Nutr. 1999;81(6):447-55.

Derouicha M, Bouhlali EDT, Hmidani A, Bammouc M, Bourkhis B, Sellamc K et al. Assessment of total polyphenols, flavonoids and anti-inflammatory potential of three Apiaceae species grown in the Southeast of Morocco. Sci Afr. 2020;9:e00507.

Wong PYY, Kitts DD. Studies on the dual antioxidant and antibacterial properties of parsley (Petroselinum crispum) and cilantro (Coriandrum sativum) extracts. Food Chem. 2006;97(3):505-15.

Ojala T, Remes S, Haansuu P, Vuorela H, Hiltunen R, Haahtela K et al. Antimicrobial activity of some coumarin containing herbal plants growing in Finland. J Ethnopharmacol. 2000;73(1-2):299-305.

Ajebli M, Eddouks M. Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats. J Ethnopharmacol. 2019;242:112039.

Al-Howiriny T, Al-Sohaibani M, El-Tahir K, Rafatullah S. Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum. Am J Chin Med. 2003;31(5):699-711.

Kreydiyyeh SI, Usta J, Kaouk I, Sadi RA. The mechanism underlying the laxative properties of Parsley extract. Phytomedicine. 2001;8(5):382-8.

Yoshikawa M, Uemura T, Shimoda H, Kishi A, Kawahara Y, Matsuda H. Medicinal foodstuffs. XVIII. Phytoestrogens from the aerial part of Petroselinum crispum MIll. (Parsley) and structures of 6"-acetylapiin and a new monoterpene glycoside, petroside. Chem Pharm Bull (Tokyo). 2000;48(7):1039-44.

Chaves DS, Frattani FS, Assafim M, de Almeida AP, de Zingali RB, Costa SS.. Phenolic chemical composition of Petroselinum crispum extract and its effect on haemostasis. Nat Prod Commun. 2011;6(7):961-4.

Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Bruel A et al. Flavonoids purified from parsley inhibit human blood platelet aggregation and adhesion to collagen under flow. J Complement Integr Med. 2012;9:Article 19.

Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Legrand C et al. Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol. 2009;125(1):170-4.

Abdel-Wahhab MA, Abbes S, Salah-Abbes JB, Hassan AM, Oueslati R. Parsley oil protects against Zearalenone-induced alteration in reproductive function in male mice. Toxicol Lett. 2006;164:S266.

Behtash N, Kargarzadeh F, Shafaroudi H. Analgesic effects of seed extract from Petroselinum crispum (Tagetes minuta) in animal models. Toxicol Lett. 2008;180(Suppl5):S127-S128.

Yousofi A, Daneshmandi S, Soleimani N, Bagheri K, Karimi MH. Immunomodulatory effect of Parsley (Petroselinum crispum) essential oil on immune cells: mitogen-activated splenocytes and peritoneal macrophages. Immunopharmacol Immunotoxicol. 2012;34(2):303-8.

Wang J, Wang S, Sun M, Xu H, Liu W, Wang D et al. Identification of geraldol as an inhibitor of aquaporin‐4 binding by NMO‐IgG. Mol Med Rep. 2020;22:1111-18.

Peroutka R, Schulzová V, Botek P, Hajšlová J. Analysis of furanocoumarins in vegetables (Apiaceae) and citrus fruits (Rutaceae). J Sci Food Agric. 2007;87(11):2152-63.

Tucakov J. Lečenje biljem, 2nd ed. Beograd: Rad; 1984. 735 p.

Šavikin K, Zdunić G, Menković N, Živković J, Ćujić N, Tereščenko M et al. Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor district. J Ethnopharmacol. 2013;146 (3):803-10.

Published
2021/06/07
Section
Review articles