Enzimski i lipidni markeri u proceni rizika za nastanak kardiovaskularnih bolesti kod žena u menopauzi

  • Aleksandra Klisić Univerzitet Crne Gore – Medicinski fakultet, Podgorica, Crna Gora
  • Filiz Mercantepe Univerzitet Recep Tayyip Erdogan, Medicinski fakultet, Odsek za endokrinologiju i metabolizam, Rize, Turska
  • Mirjana Bakić Univerzitet Crne Gore - Medicinski fakultet, Podgorica, Crna Gora; Klinika za dermatovenerologiju, Klinički centar Crne Gore, Podgorica, Crna Gora
  • Ana Ninić Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za medicinsku biohemiju, Beograd, Srbija
DOI: https://doi.org/10.5937/arhfarm75-53949
Ključne reči: kardiovaskularni rizik, gama-glutamil transferaza, lipoproteini, postmenopauza

Sažetak


Žene u postmenopauzi su pod povećanim rizikom od kardiovaskularnih bolesti (KVB), vodećeg uzroka smrti širom sveta, u poređenju sa mlađim ženama. Gama-glutamil transferaza (GGT) i koncentracija holesterola u lipoproteinima visoke gustine (HDL-c) povezani su sa oksidativnim stresom, upalom, insulinskom rezistencijom i faktorima rizika za KVB. Međutim, ne postoje studije koje su ispitivale odnos između GGT/HDL-c i KVB isključivo kod žena koje nisu u reproduktivnom dobu. Stoga smo imali za cilj da ispitamo pomenuti potencijalni odnos u kohorti žena u postmenopauzi bez KVB. Ukupno je uključeno 150 zdravih žena u postmenopauzi. Rizik od KVB je definisan prema koncentraciji visokosenzitivnog C-reaktivnog proteina (hsCRP) (hsCRP < 1 mg/L definiše nizak rizik, a hsCRP ≥ 1 mg/L definiše srednji i visoki rizik). GGT/HDL-c je bio nezavisno povezan sa srednjim i visokim rizikom od KVB kod žena u postmenopauzi. S povećanjem ovog enzimskog/lipidnog indeksa za 1 jedinicu, verovatnoća srednjeg i visokog rizika od KVB porasla je za 10,3% (OR = 1,103, p = 0,024). Odnos GGT/HDL-c je nezavisno povezan sa većim rizikom od KVB, merenim pomoću hsCRP kod žena u postmenopauzi. Ovaj isplativ, lako merljiv i široko dostupan indeks mogao bi se koristiti u svakodnevnoj kliničkoj praksi za procenu rizika od KVB kod žena u postmenopauzi.

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Objavljeno
2025/02/23
Broj časopisa
Vol. 75 Br. Notebook 1 (2025): Arhiv za farmaciju
Rubrika
Originalni naučni rad
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