Koenzim Q 10 (ubikvinon) i bolesti mozga – veza sa okom i telom
Ključne reči:
Koenzim Q10, kognicija, depresija, mitohondrije
Sažetak
Koenzim Q10 (CoQ10; ubikvinon) je supstanca slična vitaminima koja je uključena u respiratorni lanac u mitrohondrijama. Ubikvinon se sintetiše u svim tkivima ali sa godinama sadržaj opada, kao i u nekim patološkim stanjima i kod primene statina. Ubikvinon je neophodan za rast i održavanje ćelija u lјudskom organizmu i sa starenjem poželjan je unos sa hranom, jer endogena sinteza više nije dovoljna.
CoQ10 učestvuje u oksidativnoj fosforilaciji i produkciji adenozin trifosfata (ATP) i predstavlјa moćan antioksidant. Primarni deficiti CoQ10 se ispoljavaju kao multisistemska bolest, encefalomiopatija, cerebelarna ataksija, miopatija i nefrotski sindrom. U slučaju nedostatka CoQ10 nastaju prvo reaktivne kiseoničke vrste, a kod težeg deficita i gubitak ATP. Nedostatak CoQ10 izaziva takođe apoptozu što je nađeno u mozgu i retini starijih osoba. Nedostatak CoQ10 doprinosi poremećaju rada srčanog mišića u hroničnoj srčanoj insuficijenciji. Efekti nedostatka CoQ10 su inflamacija i oksidativni stres.
Pokazan je inverzni odnos serumskog CoQ10 i rizika od nastajanja demencije. Davanje CoQ10 dovodilo je do smanjenje depresivnosti kod bolesnika sa metaboličkim sindromom kao i poboljšanje koncentracije u shizofreniji i shizoafektivnom poremećaju. Primena CoQ10 može da smanji učestalost i jačinu napada migrene. Nedostatak CoQ10 može da bude povezan sa pojavom miopatije kod davanja statina. Kod osoba sa primarnim deficijencijama CoQ10 postoji retinopatija, a kod stečene makularne degeneracije i glaukoma nivoi CoQ10 su sniženi. Visoke doze CoQ10 pomažu preživlјavanju kod hronične srčane insuficijencije i koronarne bolesti. Pokazani su povoljni efekti CoQ10 na lečenje gojaznosti, oksidativnog stresa, metaboličkog sindroma, dijabetes mellitusa tip II i nealkoholne masne jetre. Primena kod zamora je kontroverzna. Pokazan je izvestan pozitivni efekat primene CoQ10 kod karcinoma dojke. Ispitivanja ukazuju da primena CoQ10 ima povoljna dejstva u ranoj fazi sepse.
U terapijske svrhe CoQ10 se daje u dozama od 30-3000 mg. Doze od 22 mg do 400 mg/dan se smatraju bezbednim. Neželjeni efekti su uglavnom blagi i retki.
Reference
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2. Hargreaves IP, Mantle D.Coenzyme Q10 Supplementation in Fibrosis and Aging. Adv Exp Med Biol 2019;1178:103-112.
3. Pavlović DM. Ortomolekularna neurologija i psihijatrija. Kako poboljšati rad mozga uz pomoć suplemanata/mikronutrijenata. Beograd: OrionArt; 2019.
4. Acosta MJ, Vazquez Fonseca L, Desbats MA, Cerqua C, Zordan R, Trevisson E, Salviati L. Coenzyme Q biosynthesis in health and disease. Biochim Biophys Acta 2016;1857(8) [1] :1079-85.
5. Bhagavan HN, Chopra RK. Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radical Research 2006;40(5) [1] :445–453.
6. Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr 2010;50(4):269-80.
7. Weber C. Dietary intake and absorption of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: Molecular Mechanisms in Health and Disease. Boca Raton: CRC Press; 2001:209-15.
8. Raizner AE. Coenzyme Q10. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):185-191.
9. Pavlović DM. Mentalno zdravlјe školske dece. Beograd: Orion Art, 2014.
10. Ozawa Y, Mizushima Y, Koyama I, Akimoto M, Yamagata Y, Hayashi H, Murayama H. Intestinal absorption enhancement of coenzyme Q10 with a lipid microsphere. Arzneimittel-Forschung 1986;36(4):689-90.
11. Zhang P, Yang C, Guo H, Wang J, Lin S, Li H, Yang Y, Ling W. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals. J Clin Lipidol. 2018 Mar-Apr 12(2):417-427.e5.
12. Casagrande D, Waib PH, Jordao Júnior AA. Mechanisms of action and effects of the administration of Coenzyme Q10 on metabolic syndrome. J Nutr Intermed Metab 2018 September (13):26-32.
13. Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Archives of Biochemistry and Biophysics 1992;295(2):230-4.
14. Dutton PL, Ohnishi T, Darrouzet E, Leonard MA, Sharp RE, Cibney BR et al 4 Coenzyme Q oxidation reduction reactions in mitochondrial electron transport. In Kagan VE, Quinn PJ (eds.). Coenzyme Q: Molecular mechanisms in health and disease. Boca Raton: CRC Press. 2000;pp. 65-82.
15. Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 2007;7 Suppl:S34-40.
16. Kagan VE, Fabisak JP, Tyurina YY. Independent and concerted antioxidant functions of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: Molecular Mechanisms in Health and Disease. Boca Raton: CRC Press; 2001:119-30.
17. Arenas-Jal M, Suñé-Negre JM, García-Montoya E. Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf. 2020 Mar;19(2):574-594.
18. Manzar H, Abdulhussein D, Yap TE, Cordeiro MF. Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain. Int J Mol Sci. 2020 Dec 6;21(23):9299.
19. Fragaki K, Chaussenot A, Benoist JF, Ait-El-Mkadem S, Bannwarth S, Rouzier C, et al. Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes. Biol Res 2016;49:4.
20. Ben-Meir A, Yahalomi S, Moshe B, Shufaro Y, Reubinoff B, Saada A. Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging. Fertil Steril 2015;104(3):724-7.
21. Mehmetoglu I, Yerlikaya FH, Kurban S. Correlation between vitamin A, E, coenzyme Q(10) and degree of insulin resistance in obese and non-obese subjects. J Clin Biochem Nutr. 2011 Nov;49(3):159-63.
22. Alehagen U, Aaseth J, Alexander J, Johansson P. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS One 2018;13(4):e0193120.
23. Pavlović DM. Depresija i demencija. Engrami 2002;24:63-80.
24. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutr Neurosci. 2016;19(3):138-43.
25. Maguire Á, Mooney C, Flynn G, Ferguson Y, O'Keane V, O'Rourke D, McMonagle T, Heaton R, Phillips S, Hargreaves I, Gill M, Hargreaves A. No Effect of Coenzyme Q10 on cognitive function, psychological symptoms, and health-related outcomes in schizophrenia and schizoaffective disorder: results of a randomized, placebo-controlled trial. J Clin Psychopharmacol. 2021 Jan/Feb 01;41(1):53-7.
26. Hargreaves IP. Coenzyme Q10 as a therapy for mitochondrial disease. Int J Biochem Cell Biol. 2014;49:105-11.
27. Pavlović DM, Pavlović AM. Mešovita demencija. Engrami 2012:34(1):39-47.
28. Pavlović D, Ocić G, Stefanova E, Smiljković P, Žugić S, Đorđević J. Dysexecutive syndrome in patients with dementia od Alzheimer's type - a pilot study. Engrami 1995;17:23-34.
29. Yamagishi K, Ikeda A, Moriyama Y, Chei CL, Noda H, Umesawa M, Cui R, Nagao M, Kitamura A, Yamamoto Y, Asada T, Iso H; CIRCS Investigators. Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis. 2014 Dec;237(2):400-3.
30. Choi H, Park HH, Koh SH, Choi NY, Yu HJ, Park J, Lee YJ, Lee KY. Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway. Neurotoxicology. 2012 Jan;33(1):85-90.
31. García-Carpintero S, Domínguez-Bértalo J, Pedrero-Prieto C, Frontiñán-Rubio J, Amo-Salas M, Durán-Prado M, García-Pérez E, Vaamonde J, Alcain FJ. Ubiquinol Supplementation improves gender-dependent cerebral vasoreactivity and ameliorates chronic inflammation and endothelial dysfunction in patients with mild cognitive impairment. Antioxidants (Basel). 2021 Jan 20;10(2):143.
32. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S,et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59(10):1541-50.
33. McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, et al. A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. Neurology. 2017;88(2):152-9.
34. Hart PE, Lodi R, Rajagopalan B, Bradley JL, Crilley JG, Turner C, et al. Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up. Arch Neurol. 2005;62(4):621-6.
35. Lo RY, Figueroa KP, Pulst SM, Lin CY, Perlman S, Wilmot G, et al. Coenzyme Q10 and spinocerebellar ataxias. Mov Disord. 2015;30(2):214-20.
36. Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, Akbari Oryani M. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg. 2017;117(1):103-9.
37. Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci 2019 Sep;22(9):607-615.
38. Qu H, Meng YY, Chai H, Liang F, Zhang JY, Gao ZY, Shi DZ. The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials. Eur J Med Res. 2018 Nov 10;23(1):57.
39. Karakahya RH, Özcan TŞ. Salvage of the retinal ganglion cells in transition phase in Alzheimer's disease with topical coenzyme Q10: is it possible? Graefes Arch Clin Exp Ophthalmol. 2020 Feb;258(2):411-8.
40. Postorino EI, Rania L, Aragona E, Mannucci C, Alibrandi A, Calapai G, Puzzolo D, Aragona P. Efficacy of eyedrops containing cross-linked hyaluronic acid and coenzyme Q10 in treating patients with mild to moderate dry eye. Eur J Ophthalmol. 2018 Jan;28(1):25-31.
41. Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Balacco Gabrieli C. () [1] Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-l-carnitine, n-3 fatty acids, and coenzyme Q10. Int J Ophthalmol 2015;219:154-66
42. Paris V, Centofanti M, Gandolfi S, Marangoni D, Rossetti L, Tanga L et al. Effects of coenzyme Q10 in conjunction with vitamin E on retinal-evoked and cortical-evoked responses in patients with open-angle glaucoma. J Glaucoma 2014;23:391-404
43. Chistiakov DA, Shkurat TP, Melnichenko AA, Grechko AV, Orekhov AN. The role of mitochondrial dysfunction in cardiovascular disease: a brief review. Ann Med. 2018 Mar;50(2):121-7.
44. Molyneux SL, Florkowski CM, George PM, Pilbrow AP, Frampton CM, Lever M, Richards AM. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.
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2. Hargreaves IP, Mantle D.Coenzyme Q10 Supplementation in Fibrosis and Aging. Adv Exp Med Biol 2019;1178:103-112.
3. Pavlović DM. Ortomolekularna neurologija i psihijatrija. Kako poboljšati rad mozga uz pomoć suplemanata/mikronutrijenata. Beograd: OrionArt; 2019.
4. Acosta MJ, Vazquez Fonseca L, Desbats MA, Cerqua C, Zordan R, Trevisson E, Salviati L. Coenzyme Q biosynthesis in health and disease. Biochim Biophys Acta 2016;1857(8) [1] :1079-85.
5. Bhagavan HN, Chopra RK. Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radical Research 2006;40(5) [1] :445–453.
6. Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr 2010;50(4):269-80.
7. Weber C. Dietary intake and absorption of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: Molecular Mechanisms in Health and Disease. Boca Raton: CRC Press; 2001:209-15.
8. Raizner AE. Coenzyme Q10. Methodist Debakey Cardiovasc J. 2019 Jul-Sep;15(3):185-191.
9. Pavlović DM. Mentalno zdravlјe školske dece. Beograd: Orion Art, 2014.
10. Ozawa Y, Mizushima Y, Koyama I, Akimoto M, Yamagata Y, Hayashi H, Murayama H. Intestinal absorption enhancement of coenzyme Q10 with a lipid microsphere. Arzneimittel-Forschung 1986;36(4):689-90.
11. Zhang P, Yang C, Guo H, Wang J, Lin S, Li H, Yang Y, Ling W. Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals. J Clin Lipidol. 2018 Mar-Apr 12(2):417-427.e5.
12. Casagrande D, Waib PH, Jordao Júnior AA. Mechanisms of action and effects of the administration of Coenzyme Q10 on metabolic syndrome. J Nutr Intermed Metab 2018 September (13):26-32.
13. Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Archives of Biochemistry and Biophysics 1992;295(2):230-4.
14. Dutton PL, Ohnishi T, Darrouzet E, Leonard MA, Sharp RE, Cibney BR et al 4 Coenzyme Q oxidation reduction reactions in mitochondrial electron transport. In Kagan VE, Quinn PJ (eds.). Coenzyme Q: Molecular mechanisms in health and disease. Boca Raton: CRC Press. 2000;pp. 65-82.
15. Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 2007;7 Suppl:S34-40.
16. Kagan VE, Fabisak JP, Tyurina YY. Independent and concerted antioxidant functions of coenzyme Q. In: Kagan VE, Quinn PJ, eds. Coenzyme Q: Molecular Mechanisms in Health and Disease. Boca Raton: CRC Press; 2001:119-30.
17. Arenas-Jal M, Suñé-Negre JM, García-Montoya E. Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf. 2020 Mar;19(2):574-594.
18. Manzar H, Abdulhussein D, Yap TE, Cordeiro MF. Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain. Int J Mol Sci. 2020 Dec 6;21(23):9299.
19. Fragaki K, Chaussenot A, Benoist JF, Ait-El-Mkadem S, Bannwarth S, Rouzier C, et al. Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes. Biol Res 2016;49:4.
20. Ben-Meir A, Yahalomi S, Moshe B, Shufaro Y, Reubinoff B, Saada A. Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging. Fertil Steril 2015;104(3):724-7.
21. Mehmetoglu I, Yerlikaya FH, Kurban S. Correlation between vitamin A, E, coenzyme Q(10) and degree of insulin resistance in obese and non-obese subjects. J Clin Biochem Nutr. 2011 Nov;49(3):159-63.
22. Alehagen U, Aaseth J, Alexander J, Johansson P. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS One 2018;13(4):e0193120.
23. Pavlović DM. Depresija i demencija. Engrami 2002;24:63-80.
24. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial. Nutr Neurosci. 2016;19(3):138-43.
25. Maguire Á, Mooney C, Flynn G, Ferguson Y, O'Keane V, O'Rourke D, McMonagle T, Heaton R, Phillips S, Hargreaves I, Gill M, Hargreaves A. No Effect of Coenzyme Q10 on cognitive function, psychological symptoms, and health-related outcomes in schizophrenia and schizoaffective disorder: results of a randomized, placebo-controlled trial. J Clin Psychopharmacol. 2021 Jan/Feb 01;41(1):53-7.
26. Hargreaves IP. Coenzyme Q10 as a therapy for mitochondrial disease. Int J Biochem Cell Biol. 2014;49:105-11.
27. Pavlović DM, Pavlović AM. Mešovita demencija. Engrami 2012:34(1):39-47.
28. Pavlović D, Ocić G, Stefanova E, Smiljković P, Žugić S, Đorđević J. Dysexecutive syndrome in patients with dementia od Alzheimer's type - a pilot study. Engrami 1995;17:23-34.
29. Yamagishi K, Ikeda A, Moriyama Y, Chei CL, Noda H, Umesawa M, Cui R, Nagao M, Kitamura A, Yamamoto Y, Asada T, Iso H; CIRCS Investigators. Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis. 2014 Dec;237(2):400-3.
30. Choi H, Park HH, Koh SH, Choi NY, Yu HJ, Park J, Lee YJ, Lee KY. Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway. Neurotoxicology. 2012 Jan;33(1):85-90.
31. García-Carpintero S, Domínguez-Bértalo J, Pedrero-Prieto C, Frontiñán-Rubio J, Amo-Salas M, Durán-Prado M, García-Pérez E, Vaamonde J, Alcain FJ. Ubiquinol Supplementation improves gender-dependent cerebral vasoreactivity and ameliorates chronic inflammation and endothelial dysfunction in patients with mild cognitive impairment. Antioxidants (Basel). 2021 Jan 20;10(2):143.
32. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S,et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002;59(10):1541-50.
33. McGarry A, McDermott M, Kieburtz K, de Blieck EA, Beal F, Marder K, et al. A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease. Neurology. 2017;88(2):152-9.
34. Hart PE, Lodi R, Rajagopalan B, Bradley JL, Crilley JG, Turner C, et al. Antioxidant treatment of patients with Friedreich ataxia: four-year follow-up. Arch Neurol. 2005;62(4):621-6.
35. Lo RY, Figueroa KP, Pulst SM, Lin CY, Perlman S, Wilmot G, et al. Coenzyme Q10 and spinocerebellar ataxias. Mov Disord. 2015;30(2):214-20.
36. Shoeibi A, Olfati N, Soltani Sabi M, Salehi M, Mali S, Akbari Oryani M. Effectiveness of coenzyme Q10 in prophylactic treatment of migraine headache: an open-label, add-on, controlled trial. Acta Neurol Belg. 2017;117(1):103-9.
37. Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci 2019 Sep;22(9):607-615.
38. Qu H, Meng YY, Chai H, Liang F, Zhang JY, Gao ZY, Shi DZ. The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials. Eur J Med Res. 2018 Nov 10;23(1):57.
39. Karakahya RH, Özcan TŞ. Salvage of the retinal ganglion cells in transition phase in Alzheimer's disease with topical coenzyme Q10: is it possible? Graefes Arch Clin Exp Ophthalmol. 2020 Feb;258(2):411-8.
40. Postorino EI, Rania L, Aragona E, Mannucci C, Alibrandi A, Calapai G, Puzzolo D, Aragona P. Efficacy of eyedrops containing cross-linked hyaluronic acid and coenzyme Q10 in treating patients with mild to moderate dry eye. Eur J Ophthalmol. 2018 Jan;28(1):25-31.
41. Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Balacco Gabrieli C. () [1] Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-l-carnitine, n-3 fatty acids, and coenzyme Q10. Int J Ophthalmol 2015;219:154-66
42. Paris V, Centofanti M, Gandolfi S, Marangoni D, Rossetti L, Tanga L et al. Effects of coenzyme Q10 in conjunction with vitamin E on retinal-evoked and cortical-evoked responses in patients with open-angle glaucoma. J Glaucoma 2014;23:391-404
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44. Molyneux SL, Florkowski CM, George PM, Pilbrow AP, Frampton CM, Lever M, Richards AM. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.
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Objavljeno
2021/09/03
Kako citirati
Pavlović, D. (2021). Koenzim Q 10 (ubikvinon) i bolesti mozga – veza sa okom i telom. Engrami, 43(1). https://doi.org/10.5937/engrami43-32423
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