TRANSMISIJA VIRUSA SARS-COV-2 U PORODICI
Ključne reči:
SARS-COV-2, RT-PCR test, laboratorija, intersticijalna pneumonija, pandemija
Sažetak
Uvod Prikazujemo transmisiju SARS-COV-2 u okviru porodice, kod pacijenata različite starosne grupe, različitog pola sa razvojem polimorfne kliničke slike i objektivnog statusa ali i različitog načina zaražavanja.Prikazi bolesnika Opisana su tri pacijenta, različite ali specifične simptomatologije za koronavirusnu bolest. Dijapazon simptoma kretao se od malaksalosti, gubitka apetita bez drugih tegoba do groznice, visoke febrilnosti, dijareje, bolova u mišićima i grudnom košu pri inspirijumu. Suv neproduktivan kašalj, nedostatak vazduha, kratak dah pri naporu uz preznojavanje, glavobolju i afebrilnost, karakterisale su treću obolelu osobu, kod koje je i radiografski verifikovana obostrana pneumonija. Laboratorijske analize ukazale su na virusnu infekciju SARS-COV-2, što je i potvrđeno RT-PCR testom u sva tri slučaja. Nakon hospitalizacije i primene simtomatske, antivirusne i antibiotske terapije, dolazi do regresije bolesti i negativizacije testova.Zaključak Opisani slučajevi potvrđuju mogućnost brzog zaražavanja u okviru porodice, direktnim i indirektnim putem, kao i polimorfnost kliničke slike, laboratorijskih nalaza i objektivnog statusa obolelih.
Reference
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11. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191:145-147. doi:10.1016/j.thromres.2020.04.013.
12. Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med. 2020; 46: 1339–1348. https://doi.org/10.1007/s00134-020-06153-9.
13. Clemency BM, Varughese R, Scheafer DK, Ludwig B, Welch JV, McCormack RF, et al. Symptom Criteria for COVID-19 Testing of Heath Care Workers. Acad Emerg Med. 2020;27(6):469-474. PMID: 32396670. doi:10.1111/acem.14009.
14. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-1009. PMID: 32213556. doi:10.1136/gutjnl-2020-320926.
15. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020 ;115(5):766-773. PMID: 32287140. DOI: 10.14309/ajg.0000000000000620.
16. Rivett L, Sridhar S, Sparkes D, Routledge M, Jones NK, Forrest S, et al. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. Elife. 2020; 9: e58728. PMID: 32392129. doi: 10.7554/eLife.58728
17. Petruzzi G, De Virgilio A, Pichi B, Mazzola F, Zocchi J, Mercante G, et al. COVID-19: Nasal and oropharyngeal swab. Head Neck. 2020;42(6):1303-1304. PMID: 32352180. doi:10.1002/hed.26212.
18. Letícia S, Toledo O, Sousa Nogueira L, das Graças Carvalho M, Romana D, Rios A, et al. COVID-19: Review and hematologic impact. Clinica Chimica Acta. 2020: 510:170-176. PMID: 32659224. doi: 10.1016/j.cca.2020.07.016.
19. Seitz R, Schramm W. DIC in COVID-19: Implications for prognosis and treatment? PMID: 32344469. doi: 10.1111/jth.14878.
20. Juul S, Nielsen N, Bentzer P, Veroniki AA, Thabane L, Linder A, et al. Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project). Syst Rev. 2020;9(1):108. PMID: 32386514. doi:10.1186/s13643-020-01371-0
2. Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. Int J Biol Sci. 2020;16(10):1678-1685. PMID: 32226285. doi:10.7150/ijbs.45053.
3. Wölfer R, Christ O, Schmid K, Tausch N, Buchallik MF, Vertovec S, et al. Indirect contact predicts direct contact: Longitudinal evidence and the mediating role of intergroup anxiety. J Pers Soc Psychol. 2019;116(2):277-295. PMID: 30382741. doi:10.1037/pspi0000146.
4. European Centre for Disease Prevention and Control (ECDC). Q & A on novel coronavirus. Stockholm: ECDC; 2020. [Accessed 24 Feb 2020]. Available from: https://www.ecdc.europa.eu/en/novel-coronavirus-china/questions-answers.
5. Bulut C, Kato Y. Epidemiology of COVID-19. Turk J Med Sci. 2020;50(SI-1):563-570. PMID: 32299206. doi:10.3906/sag-2004-172.
6. Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020; 58(7): 1131–1134. DOI: https://doi.org/10.1515/cclm-2020-0198.
7. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17(39):20285. PMID: 23041020. doi:10.2807/ese.17.39.20285-en.
8. Lei J, Li J, Li X, Qi X. CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. 2020; 295(1):18. PMID: 32003646. doi: 10.1148/radiol.2020200236.
9. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published correction appears in BMJ. 2020;368:m1295]. BMJ. 2020;368:m1091. PMID: 32217556. doi:10.1136/bmj.m1091.
10. Pinzon RT, Wijaya VO, Buana RB, Al Jody A and Nunsio PN. Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis. Front. Neurol. 2020; 11:565. doi: 10.3389/fneur.2020.00565.
11. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191:145-147. doi:10.1016/j.thromres.2020.04.013.
12. Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med. 2020; 46: 1339–1348. https://doi.org/10.1007/s00134-020-06153-9.
13. Clemency BM, Varughese R, Scheafer DK, Ludwig B, Welch JV, McCormack RF, et al. Symptom Criteria for COVID-19 Testing of Heath Care Workers. Acad Emerg Med. 2020;27(6):469-474. PMID: 32396670. doi:10.1111/acem.14009.
14. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-1009. PMID: 32213556. doi:10.1136/gutjnl-2020-320926.
15. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020 ;115(5):766-773. PMID: 32287140. DOI: 10.14309/ajg.0000000000000620.
16. Rivett L, Sridhar S, Sparkes D, Routledge M, Jones NK, Forrest S, et al. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. Elife. 2020; 9: e58728. PMID: 32392129. doi: 10.7554/eLife.58728
17. Petruzzi G, De Virgilio A, Pichi B, Mazzola F, Zocchi J, Mercante G, et al. COVID-19: Nasal and oropharyngeal swab. Head Neck. 2020;42(6):1303-1304. PMID: 32352180. doi:10.1002/hed.26212.
18. Letícia S, Toledo O, Sousa Nogueira L, das Graças Carvalho M, Romana D, Rios A, et al. COVID-19: Review and hematologic impact. Clinica Chimica Acta. 2020: 510:170-176. PMID: 32659224. doi: 10.1016/j.cca.2020.07.016.
19. Seitz R, Schramm W. DIC in COVID-19: Implications for prognosis and treatment? PMID: 32344469. doi: 10.1111/jth.14878.
20. Juul S, Nielsen N, Bentzer P, Veroniki AA, Thabane L, Linder A, et al. Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project). Syst Rev. 2020;9(1):108. PMID: 32386514. doi:10.1186/s13643-020-01371-0
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