A family claster of SARS-COV-!) infection
Keywords:
SARS-COV-19, RT-PCR test, laboratory, intersticial pmeumonia, pandemic
Abstract
Introduction We present the transmission of SARS-COV-2 within the family, in patients of different age groups, different sexes with the development of polymorphic clinical picture and objective status, but also different ways of infection. The range of symptoms ranged from malaise, loss of appetite without other ailments to fever, high fever, diarrhea, muscle and chest pain on inspiration. Dry, unproductive cough, shortness of breath, shortness of breath on exertion with sweating, headache and afebrile, characterized the third person, in whom bilateral pneumonia was also radiographically verified. Laboratory analyzes indicated SARS-COV-2 viral infection, which was confirmed by RT-PCR test in all three cases. After hospitalization and application of symptomatic, antiviral and antibiotic therapy, the disease regresses and tests are negative. Conclusion The described cases confirm the possibility of rapid infection within the family, directly and indirectly, as well as polymorphism of clinical picture, laboratory findings and objective status of patients.
References
1. Rabi FA, Al Zoubi MS, Kasasbeh GA, Salameh DM, Al-Nasser AD. SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. Pathogens. 2020;9(3):231. PMID: 32245083. doi:10.3390/pathogens9030231.
2. Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. Int J Biol Sci. 2020;16(10):1678-1685. PMID: 32226285. doi:10.7150/ijbs.45053.
3. Wölfer R, Christ O, Schmid K, Tausch N, Buchallik MF, Vertovec S, et al. Indirect contact predicts direct contact: Longitudinal evidence and the mediating role of intergroup anxiety. J Pers Soc Psychol. 2019;116(2):277-295. PMID: 30382741. doi:10.1037/pspi0000146.
4. European Centre for Disease Prevention and Control (ECDC). Q & A on novel coronavirus. Stockholm: ECDC; 2020. [Accessed 24 Feb 2020]. Available from: https://www.ecdc.europa.eu/en/novel-coronavirus-china/questions-answers.
5. Bulut C, Kato Y. Epidemiology of COVID-19. Turk J Med Sci. 2020;50(SI-1):563-570. PMID: 32299206. doi:10.3906/sag-2004-172.
6. Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020; 58(7): 1131–1134. DOI: https://doi.org/10.1515/cclm-2020-0198.
7. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17(39):20285. PMID: 23041020. doi:10.2807/ese.17.39.20285-en.
8. Lei J, Li J, Li X, Qi X. CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. 2020; 295(1):18. PMID: 32003646. doi: 10.1148/radiol.2020200236.
9. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published correction appears in BMJ. 2020;368:m1295]. BMJ. 2020;368:m1091. PMID: 32217556. doi:10.1136/bmj.m1091.
10. Pinzon RT, Wijaya VO, Buana RB, Al Jody A and Nunsio PN. Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis. Front. Neurol. 2020; 11:565. doi: 10.3389/fneur.2020.00565.
11. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191:145-147. doi:10.1016/j.thromres.2020.04.013.
12. Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med. 2020; 46: 1339–1348. https://doi.org/10.1007/s00134-020-06153-9.
13. Clemency BM, Varughese R, Scheafer DK, Ludwig B, Welch JV, McCormack RF, et al. Symptom Criteria for COVID-19 Testing of Heath Care Workers. Acad Emerg Med. 2020;27(6):469-474. PMID: 32396670. doi:10.1111/acem.14009.
14. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-1009. PMID: 32213556. doi:10.1136/gutjnl-2020-320926.
15. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020 ;115(5):766-773. PMID: 32287140. DOI: 10.14309/ajg.0000000000000620.
16. Rivett L, Sridhar S, Sparkes D, Routledge M, Jones NK, Forrest S, et al. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. Elife. 2020; 9: e58728. PMID: 32392129. doi: 10.7554/eLife.58728
17. Petruzzi G, De Virgilio A, Pichi B, Mazzola F, Zocchi J, Mercante G, et al. COVID-19: Nasal and oropharyngeal swab. Head Neck. 2020;42(6):1303-1304. PMID: 32352180. doi:10.1002/hed.26212.
18. Letícia S, Toledo O, Sousa Nogueira L, das Graças Carvalho M, Romana D, Rios A, et al. COVID-19: Review and hematologic impact. Clinica Chimica Acta. 2020: 510:170-176. PMID: 32659224. doi: 10.1016/j.cca.2020.07.016.
19. Seitz R, Schramm W. DIC in COVID-19: Implications for prognosis and treatment? PMID: 32344469. doi: 10.1111/jth.14878.
20. Juul S, Nielsen N, Bentzer P, Veroniki AA, Thabane L, Linder A, et al. Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project). Syst Rev. 2020;9(1):108. PMID: 32386514. doi:10.1186/s13643-020-01371-0
2. Zheng J. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. Int J Biol Sci. 2020;16(10):1678-1685. PMID: 32226285. doi:10.7150/ijbs.45053.
3. Wölfer R, Christ O, Schmid K, Tausch N, Buchallik MF, Vertovec S, et al. Indirect contact predicts direct contact: Longitudinal evidence and the mediating role of intergroup anxiety. J Pers Soc Psychol. 2019;116(2):277-295. PMID: 30382741. doi:10.1037/pspi0000146.
4. European Centre for Disease Prevention and Control (ECDC). Q & A on novel coronavirus. Stockholm: ECDC; 2020. [Accessed 24 Feb 2020]. Available from: https://www.ecdc.europa.eu/en/novel-coronavirus-china/questions-answers.
5. Bulut C, Kato Y. Epidemiology of COVID-19. Turk J Med Sci. 2020;50(SI-1):563-570. PMID: 32299206. doi:10.3906/sag-2004-172.
6. Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clin Chem Lab Med. 2020; 58(7): 1131–1134. DOI: https://doi.org/10.1515/cclm-2020-0198.
7. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, Eschbach-Bludau M, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17(39):20285. PMID: 23041020. doi:10.2807/ese.17.39.20285-en.
8. Lei J, Li J, Li X, Qi X. CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. 2020; 295(1):18. PMID: 32003646. doi: 10.1148/radiol.2020200236.
9. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [published correction appears in BMJ. 2020;368:m1295]. BMJ. 2020;368:m1091. PMID: 32217556. doi:10.1136/bmj.m1091.
10. Pinzon RT, Wijaya VO, Buana RB, Al Jody A and Nunsio PN. Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis. Front. Neurol. 2020; 11:565. doi: 10.3389/fneur.2020.00565.
11. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191:145-147. doi:10.1016/j.thromres.2020.04.013.
12. Gabarre P, Dumas G, Dupont T, Darmon M, Azoulay E, Zafrani L. Acute kidney injury in critically ill patients with COVID-19. Intensive Care Med. 2020; 46: 1339–1348. https://doi.org/10.1007/s00134-020-06153-9.
13. Clemency BM, Varughese R, Scheafer DK, Ludwig B, Welch JV, McCormack RF, et al. Symptom Criteria for COVID-19 Testing of Heath Care Workers. Acad Emerg Med. 2020;27(6):469-474. PMID: 32396670. doi:10.1111/acem.14009.
14. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-1009. PMID: 32213556. doi:10.1136/gutjnl-2020-320926.
15. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020 ;115(5):766-773. PMID: 32287140. DOI: 10.14309/ajg.0000000000000620.
16. Rivett L, Sridhar S, Sparkes D, Routledge M, Jones NK, Forrest S, et al. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. Elife. 2020; 9: e58728. PMID: 32392129. doi: 10.7554/eLife.58728
17. Petruzzi G, De Virgilio A, Pichi B, Mazzola F, Zocchi J, Mercante G, et al. COVID-19: Nasal and oropharyngeal swab. Head Neck. 2020;42(6):1303-1304. PMID: 32352180. doi:10.1002/hed.26212.
18. Letícia S, Toledo O, Sousa Nogueira L, das Graças Carvalho M, Romana D, Rios A, et al. COVID-19: Review and hematologic impact. Clinica Chimica Acta. 2020: 510:170-176. PMID: 32659224. doi: 10.1016/j.cca.2020.07.016.
19. Seitz R, Schramm W. DIC in COVID-19: Implications for prognosis and treatment? PMID: 32344469. doi: 10.1111/jth.14878.
20. Juul S, Nielsen N, Bentzer P, Veroniki AA, Thabane L, Linder A, et al. Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project). Syst Rev. 2020;9(1):108. PMID: 32386514. doi:10.1186/s13643-020-01371-0
Published
2020/12/22
Section
Case report
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