Effects of ultrasound-guided lumbar-sciatic nerve block and epidural anesthesia on the levels of IL-6, IL-8, TNF-α and coagulation factors in peripheral blood of elderly patients after hip joint surgery

  • Zhi Huang 1Department of Interventional Radiology, the Affiliated Hospital of Guizhou Medical University, Guiyang 550002, P.R. China 2School of Basic Medical Science, Guizhou Medical University, Guiyang 550002, P.R. China
  • Yan Cai 3Ultrasonic center, the Affiliated Hospital of Guizhou Medical University, Guiyang 550002, P.R. China
  • Yunfei Yang 5Institute of image, Guizhou Medical University, Guiyang, 550002, P.R. China
  • Jin Shi 4Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550005, P.R. China
  • Xuya Zhao 5Institute of image, Guizhou Medical University, Guiyang, 550002, P.R. China
  • Haise Mo 5Institute of image, Guizhou Medical University, Guiyang, 550002, P.R. China
  • Qingfan Zeng Department of Anesthesiology, The Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou, 550005, P.R. China
DOI: https://doi.org/10.5937/jomb0-35847
Keywords: lumbar slave-sciatic nerve block, epidural anesthesia, inflammatory factor, coagulation factor

Abstract


Objective: To investigate the effects of different anesthesia methods on the levels of inflammatory and coagulation factors in the peripheral blood of elderly patients undergoing hip surgery.

Methods: 144 elderly patients undergoing hip arthroplasty in our hospital were randomly divided into ultrasound-guided lumbar-sciatic nerve block (group A) and epidural anesthesia (group B), 72 cases in each group. The postoperative hemodynamic indexes, pain score, inflammatory factors and coagulation factor levels were compared between the two groups.

Results: (1) The postoperative VAS score of group B patients was lower than that of group A (P<0.05); (2) The SBP and DBP of group B were higher than those of group A at T1 and T2. (both P<0.05); (3) Compared with group A, the levels of IL-6, IL-8 and TNF-α in the peripheral blood of patients in group B decreased at postoperative T2, T3 and T4 (P<0.05); (4) Compared with group A, plasma FV:C, FVIII:C and FIB in group B decreased, and TT increased during surgery after T2, T3 and T4, (all P<0.05).

Conclusion: Compared with epidural anesthesia, lumbar-sciatic nerve block can reduce the levels of peripheral blood coagulation factors and inflammatory factors after surgery.

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Published
2022/06/06
Issue
Vol. 41 No. 4 (2022): Journal of Medical Biochemistry
Section
Original paper

Copyright (c) 2022 Xingjun Ma, Huijuan Chen, Shuangshuang Guan, Qiufeng Wang, Ning Cai

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