Unique presentation of T-cell/histiocyte-rich large B cell lymphoma complicated with hemophagocytic lymphohistiocytosis: case report and review of the literature

  • Andrej Pešić Medical Doctor
  • Vojin Vuković 1Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Sofija Kozarac 1Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia
  • Vladimir Otašević 1Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia
  • Tamara Bibić 1Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia
  • Biljana Mihaljević 1Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Darko Antić 1Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia 2Faculty of Medicine, University of Belgrade, Belgrade, Serbia
DOI: https://doi.org/10.5937/jomb0-48290
Keywords: hemophagocytic lymphohistiocytosis, T-cell/histiocyte-rich large B cell lymphoma, refractory lymphoma, immune-related adverse event, case report, review of the literature

Abstract


Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory disorder characterized by dysfunction of NK cells and cytotoxic lymphocytes. We present a rare case of a patient diagnosed with HLH who presented with persistent fever during treatment for refractory T-cell/histiocyte-rich large B-cell lymphoma (TCHRBCL), highlighting the challenges of managing HLH in the context of refractory lymphoma. According to our review of the literature, this is the first case of HLH that developed several months into treatment for refractory TCHRBCL and not in close temporal relation to lymphoma diagnosis.

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Published
2024/01/08
Issue
Vol. 43 No. 4 (2024): Journal of Medical Biochemistry
Section
Case Report

Copyright (c) 2024 Andrej Pešić, Vojin Vuković, Sofija Kozarac, Vladimir Otašević, Tamara Bibić, Biljana Mihaljević, Darko Antić

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