The Prognostic value of CRP, PCT, and TNF-α, D-lactate, DAO, and endotoxin on Survival of Patients with Severe Craniocerebral Injury
Prognostic value of CRP, PCT, and TNF-α, D-lactate, DAO, and endotoxin
Abstract
Background: Hyperbaric oxygen therapy is an important treatment method for early consciousness recovery and rehabilitation after brain trauma. In this study, we investigated the effects of hyperbaric oxygen combined with probiotics nutritional supplements (PNS) on patients with severe craniocerebral injury complicated with swallowing disorders in Intensive care unit.
Methods: 74 patients with severe craniocerebral injury who received hyperbaric oxygen therapy in the ICU of our hospital from July 2020 to October 2023 were selected for retrospective analysis. Among them, 35 patients received conventional NS (control groups), and and another 39 patients received PNS (research group). Inflammatory factors, T-lymphocyte subsets, and gastrointestinal mucosal function were compared between the two groups before and after treatment. In addition, patients' neurological function was assessed using the Glasgow Coma Scale (GCS), Fugl-Meyer Assessment (FMA), and the National Institutes of Health Stroke Scale (NIHSS). Finally, the incidence of adverse effects between the two groups was counted.
Results: Compared with the control group, the research group had lower NIHSS and inflammatory factors after treatment, while FMA and GCS were higher (P<0.05). In addition, the immune function and gastrointestinal mucosal function were better in the study group (P<0.05). However, there was no statistically significant difference in the safety comparison between the two groups (P>0.05) .
Conclusion: Hyperbaric oxygen combined with PNS can better improve neurological function in patients with severe craniocerebral injury and is recommended for clinical use.
References
2. Gao Y, Li ZD, Zou DH, Ma HX, Chen YJ, Zhong LW. Parameterized Analysis of Craniocerebral Injury Caused by Fist. Fa Yi Xue Za Zhi. 2021;37(3):344-50.
3. Tian J, Zhang C, Wang Q. Analysis of craniocerebral injury in facial collision accidents. PLoS One. 2020;15(10):e0240359.
4. Yang ZH, Yin XJ, Fu GY. The correlation between CT findings of diffuse axonal injury and the expression of neuronal aquaporin in patients with craniocerebral injury. Eur Rev Med Pharmacol Sci. 2022;26(18):6871-8.
5. Harch PG, Andrews SR, Rowe CJ, Lischka JR, Townsend MH, Yu Q, et al. Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial. Med Gas Res. 2020;10(1):8-20.
6. Schimmel S, El Sayed B, Lockard G, Gordon J, Young I, D'Egidio F, et al. Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy. Int J Mol Sci. 2023;24(19).
7. Wang X, Dong Y, Han X, Qi XQ, Huang CG, Hou LJ. Nutritional support for patients sustaining traumatic brain injury: a systematic review and meta-analysis of prospective studies. PLoS One. 2013;8(3):e58838.
8. Yang L, Liao D, Hou X, Wang Y, Yang C. Systematic review and meta-analysis of the effect of nutritional support on the clinical outcome of patients with traumatic brain injury. Ann Palliat Med. 2021;10(11):11960-9.
9. Wobith M, Weimann A. Oral Nutritional Supplements and Enteral Nutrition in Patients with Gastrointestinal Surgery. Nutrients. 2021;13(8).
10. Burton I, McCormack A. Nutritional Supplements in the Clinical Management of Tendinopathy: A Scoping Review. J Sport Rehabil. 2023;32(5):493-504.
11. Kondrup J, Allison SP, Elia M, Vellas B, Plauth M, Educational, et al. ESPEN guidelines for nutrition screening 2002. Clin Nutr. 2003;22(4):415-21.
12. Mehta R, trainee GP, Chinthapalli K, consultant n. Glasgow coma scale explained. BMJ. 2019;365:l1296.
13. Gladstone DJ, Danells CJ, Black SE. The fugl-meyer assessment of motor recovery after stroke: a critical review of its measurement properties. Neurorehabil Neural Repair. 2002;16(3):232-40.
14. Kwah LK, Diong J. National Institutes of Health Stroke Scale (NIHSS). J Physiother. 2014;60(1):61.
15. Zhang W, Qin Z, Xian K, Tang S. Assessment of plasma homocysteine levels in patients with craniocerebral injury and prognosis. J Int Med Res. 2020;48(3):300060519882202.
16. Lulevitch N, Kohen B, Patel F, Dixon T, Montenegro M, Halperin M. Elderly Male with Head Injury. Ann Emerg Med. 2023;81(1):e1-e2.
17. Jiang HS, Wang YZ. Super early cranial repair improves the prognosis of patients with craniocerebral injury. J Int Med Res. 2020;48(9):300060520959485.
18. Turnagol HH, Kosar SN, Guzel Y, Aktitiz S, Atakan MM. Nutritional Considerations for Injury Prevention and Recovery in Combat Sports. Nutrients. 2021;14(1).
19. Yu J. Bifidobacterium triple viable powder/capsule: How effective it is against gastrointestinal diseases? J Gastroenterol Hepatol. 2023;38(7):1013-4.
20. Zhang J, Wan S, Gui Q. Comparison of safety, effectiveness and serum inflammatory factor indexes of Saccharomyces boulardii versus Bifidobacterium triple viable in treating children with chronic diarrhea: a randomized trial. Transl Pediatr. 2021;10(6):1677-85.
21. Zhang C, Wu QB. Comparison of safety, efficacy and serum immune indexes of Clostridium butyricum Enterococcus triple viable vs Bifidobacterium triple viable in the treatment of bronchial asthma in children. Pak J Pharm Sci. 2022;35(5):1407-14.
22. Ablin JN, Lang E, Catalogna M, Aloush V, Hadanny A, Doenyas-Barak K, et al. Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial. PLoS One. 2023;18(3):e0282406.
23. Ren B, Ye H, Shan W, Tao X, Ye Z. Effect of Hyperbaric Oxygen Intervention on Oxidative Stress and Expression of Nerve Growth Factor in Patients with Craniocerebral Injury. J Inflamm Res. 2023;16:4925-32.
24. Alashram AR, Padua E, Romagnoli C, Annino G. Hyperbaric oxygen therapy for cognitive impairments in patients with traumatic brain injury: A systematic review. Appl Neuropsychol Adult. 2023;30(5):602-13.
25. Bennett MH. Evidence brief: hyperbaric oxygen therapy (HBOT) for traumatic brain injury and/or post-traumatic stress disorder. Diving Hyperb Med. 2018;48(2):115.
26. Platzer V, Perez G, Galinier A, Genestal M, Riu-Poulenc B, Gonzalez L, et al. Protein and micronutrient deficiencies in patients with radiation cystitis and outcome after hyperbaric oxygen therapy. Clin Nutr ESPEN. 2018;23:141-7.
27. Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, Zhou R, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2017;73(10):1199-208.
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