Serum immune indicators including IgM, IgA, and IgG levels and quality of life of patients with gastrointestinal tumors during chemotherapy
Serum immune indicators in cancer
Abstract
Objective: This research attempted to clarify impact of dietary intervention on nutritional status, immune indicators including IgM, IgA, and IgG levels, and quality of life of patients with gastrointestinal tumors during chemotherapy.
Methods: The 100 patients with gastrointestinal tumors undergoing chemotherapy in our hospital from January 2023 to June 2024 received selection and division into a control group (CG) and a study group (SG) according to different nursing methods, with 50 cases each. The CG received conventional chemotherapy nursing intervention, and SG received dietary nursing on the basis of conventional nursing in CG. The nutritional indicators including body mass index (BMI), oral mucosal cell apoptosis rate, hemoglobin (HGB), and serum albumin (ALB) levels, immune indicators including IgM, IgA, and IgG levels and quality of life before and after nursing between both groups received comparison.
Results: After nursing, BMI, oral mucosa cell apoptosis rate, HGB level, and serum ALB level in both groups exhibited elevation relative to those before nursing, and SG exhibited elevation relative to CG (P < 0.05); IgM, IgA, and IgG levels in both groups exhibited elevation relative to those before nursing, and SG exhibited elevation relative to CG (P < 0.05); physical functioning scores, social functioning scores, psychological functioning scores, and material life scores in both groups exhibited elevation relative to those before nursing, and SG exhibited elevation relative to CG (P < 0.05).
Conclusion: Providing dietary nursing intervention for patients with gastrointestinal tumors during chemotherapy can effectively facilitate their nutritional status, enhance immune function, and improve their quality of life.
References
2. Movahed, S., et al., Comprehensive assessment of nutritional status and nutritional-related complications in newly diagnosed esophageal cancer patients: A cross-sectional study. Clinical nutrition (Edinburgh, Scotland), 2021. 40(6): p. 4449-4455.
3. Saragiotto, L., et al., GASTROINTESTINAL CHANGES DURING NUTRITIONAL FOLLOW-UP OF CANCER PATIENTS UNDERGOING OUTPATIENT CHEMOTHERAPY. Arquivos de gastroenterologia, 2020. 57(4): p. 354-360.
4. Nunthanawanich, P., et al., Effectiveness of Web Applications on Improving Nutritional Status of Patients with Colorectal Cancer. Nutrients, 2024. 16(3).
5. Shibata, H., et al., [A Case of an Advanced Gastric Cancer Patient with Outlet Obstruction and Malnutrition Who Successfully Underwent Neoadjuvant Chemotherapy with Enteral Nutrition]. Gan to kagaku ryoho. Cancer & chemotherapy, 2023. 50(13): p. 1897-1899.
6. Soares, J., et al., A Randomized Controlled Trial on the Effects of Leucine-Supplement Combined with Nutritional Counseling on Body Composition in Mix Cancer Older Men. Nutrients, 2024. 16(2).
7. Alonso Domínguez, T., et al., Digestive toxicity in cancer treatments. Bibliographic review. Influence on nutritional status. Endocrinologia, diabetes y nutricion, 2023. 70(2): p. 136-150.
8. Karabulut, S., et al., Does nutritional status affect treatment tolerability, chemotherapy response and survival in metastatic gastric cancer patients? Results of a prospective multicenter study in Turkey. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022. 28(1): p. 127-134.
9. Milliron, B., et al., "Keep Your Chin Up, and Keep Eating": Perceptions of Barriers and Facilitators to Healthful Dietary Behaviors Among Individuals With Gastrointestinal Cancer and Caregivers. Cancer control : journal of the Moffitt Cancer Center, 2023. 30: p. 10732748231208316.
10. Maurer, T., et al., Randomised controlled trial testing the feasibility of an exercise and nutrition intervention for patients with ovarian cancer during and after first-line chemotherapy (BENITA-study). BMJ open, 2022. 12(2): p. e054091.
11. Li, C. and P. Li, Analysis of Effect of Music and Art Combined with Kinect Game Therapy in Improving the Cognitive Function and Alleviating Negative Emotions of Alzheimer's Disease Patients in a Residential Aged Care Facilities. Alternative therapies in health and medicine, 2024.
12. Zamani, N., et al., A Single nucleotide polymorphism in the ALDH2 gene modifies the risk of esophageal squamous cell carcinoma in BRCA2 p.K3326* carriers. PloS one, 2023. 18(11): p. e0292611.
13. Tavakoli Pirzaman, A., et al., Toxic mechanisms of cadmium and exposure as a risk factor for oral and gastrointestinal carcinomas. Human & experimental toxicology, 2023. 42: p. 9603271231210262.
14. Liu, C., et al., Nutrition impact symptoms: Noteworthy prognostic indicators for lung cancer. Clinical nutrition (Edinburgh, Scotland), 2023. 42(4): p. 550-558.
15. Liu, Q., et al., A TME-activated nano-catalyst for triple synergistic therapy of colorectal cancer. Scientific reports, 2024. 14(1): p. 3328.
16. Chen, H., et al., Development of a simultaneous quantification method of imatinib and sunitinib and their main metabolites and its application in patients with gastrointestinal stromal tumor. Biomedical chromatography : BMC, 2023: p. e5804.
17. Zhang, X. and J. Ying, Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug. Current oncology (Toronto, Ont.), 2022. 29(11): p. 8235-8243.
18. Lv, L., et al., Enhanced photodynamic therapy through multienzyme-like MOF for cancer treatment. Frontiers in bioengineering and biotechnology, 2023. 11: p. 1338257.
19. Pelc, Z., et al., MalnutritiOn assessment with biOelectrical impedaNce analysis in gastRic cancer patIentS undergoing multimodaltrEatment (MOONRISE)-Study protocol for a single-arm multicenter cross-sectional longitudinal study. PloS one, 2024. 19(2): p. e0297583.
20. Fujimoto, H., et al., Reduced Relapse-Free Survival in Colorectal Cancer Patients with Elevated Soluble CD40 Ligand Levels Improved by Vitamin D Supplementation. Nutrients, 2023. 15(20).
21. Iloki Assanga, S., L. Lewis Luján, and M. McCarty, Targeting beta-catenin signaling for prevention of colorectal cancer - Nutraceutical, drug, and dietary options. European journal of pharmacology, 2023. 956: p. 175898.
22. Miller, L., et al., Impact of enteral immunonutrition on infectious complications and immune and inflammatory markers in cancer patients undergoing chemotherapy: A systematic review of randomised controlled trials. Clinical nutrition (Edinburgh, Scotland), 2022. 41(10): p. 2135-2146.
23. Ma, M., et al., Perioperative Enteral Immunonutrition Support for the Immune Function and Intestinal Mucosal Barrier in Gastric Cancer Patients Undergoing Gastrectomy: A Prospective Randomized Controlled Study. Nutrients, 2023. 15(21).
Copyright (c) 2025 Yunlong Wang
This work is licensed under a Creative Commons Attribution 4.0 International License.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.