The Impact of PDCA Cycle-Driven Nutritional Support on serum Biomarkers and Quality of Life and in Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy

Impact of PDCA Cycle-Driven Nutritional Support on serum Biomarkers

  • Weiming Xiong Jinan University, Guangzhou, China
  • Jinying Mo Department of Otolaryngology, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
  • Jingjin Weng Department of Otolaryngology, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
  • Yongli Wang Department of Otolaryngology, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
  • Jiazhang Wei Department of Otolaryngology, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
  • Linsong Ye Department of Otolaryngology, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
  • Min Li Department of Otolaryngology, Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
  • Shenhong Qu Guangxi Zhuang Autonomous Region People's Hospital, Guangxi Academy of Medical Sciences, Nanning, China
DOI: https://doi.org/10.5937/jomb0-56797
Keywords: PDCA cycle management; NPC; Radiotherapy; Nutritional support; Blood nutritional biomarkers; QoL

Abstract


Aim:This study aimed to evaluate the effectiveness of nutritional support guided by the PDCA cycle management model in nasopharyngeal carcinoma (NPC) patients undergoing radiotherapy.

Methods:A total of 100 NPC patients were randomly assigned to an observation group (OG) (n = 50) and a control group (CG) (n = 50). The CG received routine nutritional support, while the OG received PDCA cycle-based nutritional support. Key outcomes included blood nutritional biomarkers, quality of life (QoL), incidence of adverse reactions (ARs), and clinical efficacy.

Results: Post-treatment analysis revealed that the OG had a significantly higher total effective rate (72%) compared to the CG (38%) (P < 0.05). The OG demonstrated higher albumin, prealbumin, and total protein levels, along with lower CRP levels after treatment. Additionally, significant improvements were observed in cognitive, role, social, physical, and emotional functioning in the OG (P < 0.05). Furthermore, the AR rate was significantly lower in the OG (20%) compared to the CG (36%) (P < 0.05).

Conclusion: These findings suggest that PDCA cycle-based nutritional support improves clinical efficacy and QoL, minimizes nutritional risks and ARs, and enhances overall safety in NPC patients undergoing radiotherapy. Serum markers such as serum iron, ferritin, prealbumin, and CRP were effective in monitoring the impact of nutritional interventions on patients’ nutritional and inflammatory status.

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Published
2025/05/13
Issue
Vol. 44 No. 8 (2025): Journal of Medical Biochemistry
Section
Original paper

Copyright (c) 2025 Shenhong Qu

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