VEZA CIRKULIŠUĆEG NIVOA SKLEROSTINA SA MARKERIMA METABOLIZMA KOSTIJU KOD PACIJENATA SA POREMEĆAJEM RADA ŠTITASTE ŽLEZDE

  • Olgica B. Mihaljević Univerzitet u Kragujevcu, Fakultet Medicinskih nauka, Institut za patolosku fiziologiju
  • Snežana Živančević-Simonović University of Kragujevac, Faculty of Medical Science, Department of Pathophysiology
  • Aleksandra Lučić-Tomić University of Kragujevac, Faculty of Medical Science, Department of Internal Medicine
  • Irena Živković Institute of Virology, Vaccines and Sera Torlak, Department of Scientific Research
  • Rajna Minić Institute of Virology, Vaccines and Sera Torlak, Department of Scientific Research
  • Ljiljana Mijatović-Todotović University of Kragujevac, Faculty of Medical Sciences, Department of Nuclear Medicine
  • Zorica Jovanović University of Kragujevac, Faculty of Medical Science, Department of Pathophysiology
  • Marija Anđelković University of Kragujevac, Faculty of Medical Sciences, Department of Biochemistry
  • Marijana Stanojević-Pirković University of Kragujevac, Faculty of Medical Sciences, Department of Biochemistry
DOI: https://doi.org/10.5937/jomb0-24943

Sažetak


Uvod: Cilj ove studije bio je da uporedimo serumske koncentracije sklerostina kod pacijenata sa disfunkcijom štitaste žlezde u odnosu na eutiroidne kontrolne ispitanike, i da procenimo odnos između sklerostina i markera koštanog metabolizma (osteokalcina i beta-cross-lapsa) u istoj populaciji.
Metode: Studijom je obuhvaćeno 30 pacijenata sa disfunkcijom štitaste žlezde (hipotireozom, hipertireozom i subkliničkom hipertireozom) i 10 eutiroidnih kontrola. Slobodni tiroksin (FT4) meren je radioimunološkom metodom, dok je koncentracija tireostimulišućeg hormona (TSH) određivana imunoradiometrijski. Za merenje nivoa sklerostina koristili smo ELISA-test. Metoda elektrohemiluminiscencije primenjena je za merenje koncentracije koštanih markera.
Rezultati: Nivo sklerostina bio je značajno niži kod bolesnika sa hipotireozom (p = 0,009) odnosno značajno viši kod bolesnika sa hipertireozom (p = 0,008) u poređenju sa vrednostima kod eutiroidnih kontrolnih ispitanika. Pacijenti sa hipertireozom su takođe imali statistički značajno viši nivo sklerostina u odnosu na bolesnike sa subkliničkom hipertireozom (p = 0,013). Pokazana je negativna korelacija koncentracije sklerostina i TSH (r = -0,746, p < 0,001), odnosno pozitivna korelacija sa FT4 (r = 0,696, p < 0,001) kod pacijenata sa tireoidnom disfunkcijom. Štaviše, sklerostin pozitivno korelira sa koncentarcijom osteokalcina (r = 0,605, p = 0,005) i beta-cross-lapsa (r = 0,573, p = 0,008) kod ovih pacijenata.
Zaključak: Serumski nivoi sklerostina izmenjeni su kod osoba sa disfunkcijom štitaste žlezde. Sklerostin zajedno sa tireoidnim statusom utiče na koštani metabolizam, što se ogleda u njegovoj značajnoj korelaciji sa osteokalcinom i beta-cross-lapsom.
Ključne reči: beta-cross-laps, koštani metabolizam, osteokalcin, sklerostin, tireoidna disfunkcija

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Objavljeno
2020/01/27
Broj časopisa
Vol. 39 Br. 4 (2020): JMB
Rubrika
Original paper

Sva prava zadržana (c) 2020 Olgica B. Mihaljević, Snežana Živančević-Simonović, Aleksandra Lučić-Tomić, Irena Živković, Rajna Minić, Ljiljana Mijatović-Todotović, Zorica Jovanović, Marija Anđelković, Marijana Stanojević-Pirković

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