PROCJENA HEMATOLOŠKIH PARAMETARA I NJIHOVE KORELACIJE SA HEMOGLOBINOM A1C KOD BOSANSKE DJECE SA TIP 1 DIABETES MELLITUSOM I ZDRAVIH VRŠNJAKA

  • Suzana Tihić-Kapidžić Department for Clinical Biochemistry and Immunology, Clinical Center University of Sarajevo
  • Adlija Čaušević Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Bosnia and Herzegovina
  • Jasmina Fočo-Solak Department for Clinical Biochemistry and Immunology, Clinical Center University of Sarajevo, Bosnia and Herzegovina
  • Maja Malenica Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Bosnia and Herzegovina
  • Dujić Tanja Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Bosnia and Herzegovina
  • Nermina Babić Department of Human Physiology, Medical Faculty, University of Sarajevo, Bosnia and Herzegovina
  • Sniježana Hasanbegović Pediatric Clinic, Clinical Center University of Sarajevo, Bosnia and Herzegovina
  • Ermin Begović Department for Clinical Biochemistry and Immunology, Clinical Center University of Sarajevo, Bosnia and Herzegovina
DOI: https://doi.org/10.5937/jomb0-25315
Ključne reči: hematološki parametri, hemoglobin A1c, diabetes mellitus tip 1, djeca

Sažetak


Sažetak: Brojne studije ukazuju na promjene hematološkog statusa kod odrasle populacije sa dijabetesom, dok su istraživanja na djeci sa tip 1 diabetes mellitusom oskudna.  Cilj ovog istraživanja  je  bio utvrditi hematološki status kod dijabetične Bosanske djece i uporediti ga sa zdravim kontrolama te analizirati vezu hematoloških parametara sa koncentracijama glukoze i hemoglobina A1c u serumu.

Metode: U istraživanje je uključeno 100 zdrave i 100 djece sa tip 1 diabetes mellitusom, starosti od 1-18 godina. Kompletna krvna slika, hemoglobin A1c i glukoza su testirani svoj djeci.  Analiza podataka je urađena sa programom IBM SPSS Statistics, verzija 23.

Rezultati: Značajne razlike (p<0.05) između zdrave i dijabetične djece su uočene u vrijednostima HbA1c, glukoze, MPV, broju leukocita i eritrocita, hematokrita, hemoglobina i MCH. Spolne razlike u vrijednostima ispitivanih parametara nisu nađene. Starosne razlike su bile značajne za vrijednosti hemoglobina, hematokrita i MCV. Broj trombocita, MPV i MCH su pokazali starosne razlike samo kod zdrave djece. Podjela dijabetične djece prema vrijednostima HbA1c, je pokazala da postoje značajne razlike samo u broju eritrocita i vrijednosti hematokrita (p=0.013 i 0.019, respektivno). Broj eritrocita i leukocita je pokazao statistički značajne pozitivne korelacije sa HbA1c (p=0.037 i 0.027, respektivno).

Zaključci: Niže vrijednosti eritrocita, hematokrita i hemoglobina kod dijabetične u odnosu na zdravu djecu indiciraju potencijalni razvoj anemije, dok više vrijednosti MCV, MCH i MPV ukazuju na morfološke promjene eritrocita.  Hematološki parametri mogu biti jeftini i korisni pokazatelji u dijagnozi i praćenju djece sa tip 1 diabetes mellitusom.

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Objavljeno
2020/07/22
Broj časopisa
Vol. 40 Br. 2 (2021): Journal of Medical Biochemistry
Rubrika
Original paper

Sva prava zadržana (c) 2020 Suzana Tihić-Kapidžić, Adlija Čaušević, Jasmina Fočo-Solak, Maja Malenica, Dujić Tanja, Nermina Babić, Sniježana Hasanbegović, Ermin Begović

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