FGF23, αKLOTHO AND VITAMIN D MEDIATED CALCIUM-PHOSPHATE METABOLISM IN HEMODIALYSIS PATIENTS

FGF23, αKlotho, Vitamin D and Ca-P in Hemodialysis

DOI: https://doi.org/10.5937/jomb0-27408

Sažetak


Background: Klotho is a protein that acts as a co-receptor for FGF23. FGF23-Klotho axis has great importance regarding to the regulation of mineral metabolism by kidneys. In this study, we analyzed FGF23, αKlotho, 1,25-dihydroxyvitamin D3, 25-hydroxyvitamin D, parathormone, calcium and phosphate levels of hemodialysis patients in order to investigate the nature of the mineral metabolism disruption in chronic kidney diseases.

Methods: Sixty hemodialysis patients and 34 healthy controls were included in the study. Serum iFGF, cFGF, soluble αKlotho were analyzed using ELISA kits. 1,25-dihydroxyvitamin D3 was determined using LC-MS/MS. Calcium, phosphate, iPTH and 25-hydroxyvitamin D were measured using autoanalyzers.

Results: In hemodialysis patients, iFGF23, cFGF23, iPTH and P levels were significantly higher and 1,25-dihydroxyvitamin D3, αKlotho and Ca levels were significantly lower compared with the control group. There was no significant difference in 25-hydroxyvitamin D levels.

Conclusion: Our study showed that lack of sufficient amounts of αKlotho is crucial for mineral metabolism disruptions seen as a complication of chronic kidney diseases. Despite the high levels of the hormone, FGF23 is unable to accomplish its function properly, likely due to deteriorated kidney function in hemodialysis patients.

Biografije autora

Ozge Tugce Pasaoglu, Gazi University, Faculty of Health Sciences

Department of Nutrition and Dietetics, PhD

Ayse Senelmis, Gazi University, Faculty of Medicine

Department of Medical Biochemistry, PhD

Ozant Helvaci, Gazi University, Faculty of Medicine

Department of Internal Medicine, Section of Nephrology, MD

Ulver Derici, Gazi University, Faculty of Medicine

Department of Internal Medicine, Section of Nephrology, Professor

Hatice Pasaoglu, Gazi University, Faculty of Medicine

Department of Medical Biochemistry, Professor

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Objavljeno
2020/09/08
Broj časopisa
Vol. 40 Br. 2 (2021): Journal of Medical Biochemistry
Rubrika
Original paper

Sva prava zadržana (c) 2020 Ozge Tugce Pasaoglu, Ayse Senelmis, Ozant Helvaci, Ulver Derici, Hatice Pasaoglu

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