Povezanost nivoa adiponektina i rezistina u serumu sa ozbiljnošću jetrene fibroze kod pacijenata sa hroničnim hepatitisom B
Sažetak
Uvod: Novija istraživanja usko su povezala adipocitokine sa progresijom upale i fibroze jetre u bolesnika sa bezalkoholnom bolesti jetre. Cilj ovog istraživanja bio je utvrditi odnos serumskog nivoa adiponektina i rezistina sa težinom fibroze jetre u pacijenata sa hroničnim hepatitisom B (CHB), ovisno o trajanju antivirusne terapije.
Metode:Presečna studija obuhvatila je 75 pacijenata sa HHB podeljenih u dve grupe: T1 grupa (na antivirusnoj terapiji do 2 godine) i T2 grupa (na antivirusnoj terapiji preko 2 godine). Kontrolnu grupu činilo je 40 zdravih osoba. Serumske koncentracije adiponektina I rezistina procenjene su ELISA metodom, dok je stepen fibroze jetre određen pomoću FIB-4 i APRI skora.
Rezultati:Više vrednosti koncentracije rezistina u serumu potvrđene su u pacijenata sa HHB u poređenju sa zdravim kontrolama. Srednji nivo serumskog rezistina bio je značajno viši u grupi pacijenata sa većim FIB-4 skorom (9.12 ± 3.39 prema 5.58 ± 3.36 ng/mL, p = 0.001), kao I većim APRI skorom (17.45 ± 3.96ng/mL prema 4.82 ± 1.11 ng/mL, p = 0.001). Nađena je pozitivna korelacija između serumskog nivoa rezistina i stepena fibroze jetre (p <0.001). Nije bilo značajne razlike između prosečnih serumskih nivoa adiponektina u odnosu prema vrednostima FIB-4 i APRI skora.
Zaključak:Koncentracija rezistina u serumu mogla bi biti potencijalni neinvazivni biomarker ozbiljnosti fibroze jetre u pacijenata sa hroničnim hepatitisom B na antivirusnoj terapiji.
Reference
2. Senesi P, LuziL,TerruzziI. Adipokines, myokines, and cardiokines: the role of nutritional interventions. Int J MolSci 2020; 21: 8372. DOI: 10.3390/ijms21218372
3. Chang ML, YangZ,Yang SS.Roles of adipokines in digestive diseases: Markers of inflammation, metabolic alteration and disease progression.Int J MolSci 2020;21 :8308. DOI: 10.3390/ijms21218308
4. AcquaroneE, Monacelli F, Borghi R, Nencioni A, Odetti P. Resistin: areappraisal.Mech Ageing Dev 2019;178:46-63. DOI: 10.1016/j.mad.2019.01.004
5. Arunkumar EA, Sushil KJ. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J MolSci 2017;18:1321. DOI: 10.3390/ijms18061321
6. Hsu CS , Liu WL, Chao YC, et al. Adipocytokines and liver fibrosis stages in patients with chronic hepatitis B virus infection.HepatolInt 2015; 9:231-42. DOI: 10.1007/s12072-015-9616-2
7. Yalaki S,Yalcin MS. Does regression in treatment-induced liver fibrosis reflect noninvasive tests? Assessing treatment results of hepatitis B patients who took potent antiviral drugs for 5 years. Niger J ClinPract 2020; 23: 226-31. DOI: 10.4103/njcp.njcp_7_19
8. Koksal AR,Alkim H, Boga S, et al. Effect of entecavir and tenofovirtreatment on noninvasive fibrosis scores: which one is better? Am J Ther2016; 23: e429-38. DOI: 10.1097/MJT.0000000000000203
9. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin 2021; 71:7-33. DOI: 10.3322/caac.21654
10. Jamali R, Hatami N, Kosari F. The Correlation between serum adipokines and liver cell damage in non-alcoholic fatty liver disease. Hepat Mon 2016;16:e37412. DOI: 10.5812/hepatmon.37412
11. Jamali R, Razavizade M, Arj A, Aarabi MH. Serum adipokines might predict liver histology findings in non-alcoholic fatty liver disease. World J Gastroenterol 2016; 22: 5096-103. DOI: 10.3748/wjg.v22.i21.5096
12. European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol2017; 67: 370-98. DOI: 10.1016/j.jhep.2017.03.021
13. Kim WR, Berg T, Asselah T, Flisiak R, Fung S, Gordon SC, et al. Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients. J Hepatol 2016;64:773-780. DOI: 10.1016/j.jhep.2015.11.012
14. Lai M, Afdhal NH. Liver fibrosis determination.GastroenterolClin North Am 2019;48:281-9. DOI: 10.1016/j.gtc.2019.02.002
15. Mak LY, Seto WK, Fung J, Yuen MF.Novel developments of hepatitis B: treatment goals, agents and monitoring tools. Expert Rev ClinPharmacol 2019;12: 109-20. DOI: 10.1080/17512433.2019.1567327
16. Durazzo M, Belci P, Niro G, et al. Variations of serum levels of adiponectin and resistin in chronic viral hepatitis. J Endocrinol Invest 2013;36:600-5. DOI: 10.3275/8883
17. Meng Z, Zhang Y,Wei Z, et al.High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection. BMC Gastroenterol 2017; 17:6. DOI: 10.1186/s12876-016-0558-5
18. Tsochatzis E,Papatheodoridis GV, Hadziyannis E, et al. Serum adipokine levels in chronic liver diseases: association of resistin levels with fibrosis severity. Scand J Gastroenterol 2008; 43: 1128-36. DOI: 10.1080/00365520802085387
19. Da Silva TE, Costa-Silva M, Correa CG, et al. Clinical significance of serum adiponectin and resistinlevels in liver cirrhosis. Ann Hepatol 2018;17: 286-99. DOI: 10.5604/01.3001.0010.8659
20. Buechler C, Haberl EM, Rein-Fischboeck L, Aslanidis C. Adipokines in Liver Cirrhosis. Int J MolSci 2017; 18(7):1392. DOI: 10.3390/ijms18071392
21. Udomsinprasert W, Honsawek S, Poovorawan Y. Adiponectin as a novel biomarker for liver fibrosis. World J Hepatol 2018;10:708-18. DOI: 10.4254/wjh.v10.i10.708
22. Tardelli M, Moreno-Viedma V, Zeyda M, et al. Adiponectin regulates aquaglyceroporin expression in hepatic stellate cells altering their functional state. GastroenterolHepatol 2017;32: 253-60. DOI: 10.1111/jgh.13415
23. You M, Zhou Z, Daniels M, Jogasuria A. Endocrineadiponectin–FGF15/19 axis in ethanol-induced inflammation and alcoholic liver injury. Gene Expr 2018; 18: 103-13. DOI: 10.3727/105221617X15093738210295
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