The assessment value of pathological condition of serum Adiponectin and Amylin in primary osteoporosis and its correlation analysis with bone metabolism indexes
Sažetak
Objective: To explore the assessment value of pathological condition of serum adiponectin (APN) and Amylin in primary osteoporosis (POP) and their correlation with bone metabolism indexes.
Methods: From January 2019 to June 2021, selection of 79 cases of POP patients was as the research objects. Test of the bone density of the patients was conducted, and clinical grading of POP was via T value (normal, mild, moderate, severe). Analysis of the assessment value of pathological condition of serum APN and Amylin for POP and their association with bone metabolism indexes in patients was performed.
Results: APN and Amylin in patients were declined with POP’s aggravation. Patients with APN of 5.15 μg/mL or less and Amylin of 15.38 pmol/L or less were risk factors influencing the aggravation of pathological condition of POP (P < 0.05); The area under the curve (AUC) of combined detection of APN and Amylin to assess the severity of POP was elevated vs. alone test of Amylin (P < 0.05); 25-hydroxyvitamin D (25-(OH) D) and total type 1 procollagen amino-terminal propeptide (t-PINP) in patients were descended with the aggravation of pathological condition of osteoporosis (P < 0.05), while no distinct differences were presented in the three groups of type I collagen hydroxyl terminal peptide β degradation product (β-CTX) and N-terminal osteocalcin (N-MID) (P > 0.05); APN, Amylin, 25-(OH)D, β-CTX and t-PINP were negatively linked with POP clinical grade (P < 0.05); APN and Amylin were associated with 25-(OH) D, β-CTX, t-PINP (P < 0.05), and APN and Amylin were not linked with N-MID (P > 0.05).
Conclusions: Serum APN and Amylin are provided with evaluation value for the severity of POP, and are associated with the bone metabolism in patients.
Reference
[2]Yakout SM, Alharbi F, Abdi S, et al. Serum minerals (Ca, P, Co, Mn, Ni, Cd) and growth hormone (IGF-1 and IGF-2) levels in postmenopausal Saudi women with osteoporosis[J]. Medicine, 2020, 99(27):e20840.
[3]Seewordova L, Polyakova J, Zavodovsky B, et al. AB0214Adiponectin Determination in Rheumatoid Arthritis Patients Complicated by Osteoporosis[J]. Ann Rheum Dis, 2016, 75(2):970.3-971.
[4] Shaochuan Huo, Lujue Dong, Hongyu Tang, et al. Correlation analysis of bone metabolism and biochemical indexes with postmenopausal osteoporotic lumbar fractures [J]. Chongqing Medicine, 2017, 46(1): 48-50.
[5]Bauer DC, Glüer CC, Genant HK, Stone K. Quantitative ultrasound and vertebral fracture in postmenopausal women. Fracture Intervention Trial Research Group. J Bone Miner Res. 1995 Mar;10(3):353-358.
[6]Andersen G, Meiffren G, Famulla S, et al. ADO09, a co‐formulation of the amylin‐analog pramlintide and the insulin analog A21G, lowers postprandial blood glucose versus insulin lispro in type 1 diabetes (T1D)[J]. Diabetes Obes Metab, 2021, 23(4):961-970.
[7] Chinese Society of Osteoporosis and Bone Mineral Research. Diagnosis and Treatment guidelines for Primary Osteoporosis [J]. Chinese Journal of Endocrinology and Metabolism, 2017, 33(10): 890-913.
[8] Jing Huang, Shenglin Wang, Liang Zhao, et al. Application of QCT for exploration of the diagnosis and Hierarchical diagnostic criteria of osteoporosis [J]. Chinese Journal of Osteoporosis, 2003, 9(1): 37-39.
[9]Yan DD, Wang J, Hou XH, et al. Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population[J]. Acta Pharmacol Sin, 2018, 39(4):626-632.
[10]Du T, Yan Z, Zhu S, et al. QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism[J]. Cell Death Dis, 2020, 11(5):330-332.
[11]Ά Horváth, K Gulyás, Bhattoa HP, et al. FRI0547Osteoporosis and bone metabolism in systemic sclerosis[J]. Annals of the Rheumatic Diseases, 2017, 76(2):697-699.
[12]Yokomoto-Umakoshi M, Umakoshi H, Miyazawa T, et al. Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study[J]. Bone, 2020, 143(1):115777.
[13] Yuhui Zheng, Shiqiang Wu, Huafeng Zhuang. Association between bone metabolism indexes, bone mineral density and osteoporotic fracture in elderly patients with osteoporosis [J]. Chinese Journal of Gerontology, 2017, 37(23): 5920-5922.
[14]Zhou W, Liu Y, Guo X, et al. Effects of zoledronic acid on bone mineral density around prostheses and bone metabolism markers after primary total hip arthroplasty in females with postmenopausal osteoporosis[J]. Osteoporos Int, 2019, 30(8):1581-1589.
[15]Nakamura Y, Nakano M, Suzuki T, et al. Two adipocytokines, leptin and adiponectin, independently predict osteoporotic fracture risk at different bone sites in postmenopausal women[J]. Bone, 2020, 137(8):115404.
[16] Ying Wang, Ai’hua Wang, Tian Tian. Correlation of endothelin-1, adiponectin and C-reactive protein in type 2 diabetes mellitus combining with atherosclerosis and related metabolic parameters [J]. Guangdong Medical Journal, 2019, 40(7): 1020-1024.
[17]Marozik P, Alekna V, Rudenko E, et al. Bone metabolism genes variation and response to bisphosphonate treatment in women with postmenopausal osteoporosis[J]. PLoS ONE, 2019, 14(8):e0221511.
[18] Yachun Wang, Shaofa Zhou, Xiang Zhang. Associated research between IL-33 and bone mineral density and bone metabolism in postmenopausal women with osteoporosis [J]. Chinese Journal of Osteoporosis, 2020, 26(12): 1806-1809.
[19]Tominaga A, Wada K, Kato Y, et al. Early clinical effects, safety, and appropriate selection of bone markers in romosozumab treatment for osteoporosis patients: a 6-month study[J]. Osteoporos Int, 2021, 32(4):653-661.
[20]Nordklint AK, Almdal TP, Vestergaard P, et al. The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial[J]. Osteoporos Int, 2018, 29(11):2517-2526.
[21]Spadafranca A, Piuri G, Bulfoni C, et al. Adherence to the Mediterranean Diet and Serum Adiponectin Levels in Pregnancy: Results from a Cohort Study in Normal Weight Caucasian Women[J]. Nutrients, 2018, 10(7):928-931.
[22]Baker JF, Long J, Mostoufi-Moab S, et al. Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density[J]. J Rheumatol, 2017, 44(12):1777-1785.
[23]Li J, Chen X, Lu L, et al. The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis[J]. Cytokine Growth Factor Rev, 2020, 52(4):88-98.
Sva prava zadržana (c) 2022 XiaoJie Wang, Xue Bai, Ying Miu, Pan Chen, PiJun Yan, ChunXia Jiang
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