ADA KAO GLAVNI BIOHEMIJSKI MARKER KOD BOLESNIKA SA TUBERKULOZNIM IZLIVOM

ADA u tuberkuloznom pleuritisu

  • Jelena Janković Klinika za pulmologiju, Univerzitetski Klinički Centar Srbije
  • Branislav Ilic Klinika za pulmologiju, Univerzitetski klinički Centar Srbije
  • Nataša Đurđević
  • Aleksandar Jandric Klinika za pulmologiju, Univerzitetski klinički Centar Srbije
DOI: https://doi.org/10.5937/jomb0-44018
Ključne reči: adenozin deaminaza, biomarkeri, pleuralni izliv, tuberkuloza

Sažetak


Tuberkulozni pleuritis (TP) je jedan od najčešćih oblika vanplućne tuberkuloze. Zbog sporog toka bolesti i nedostatka specifičnih simptoma i dijagnostičkih metoda, tuberkulozni pleuritis je teško dijagnostikovati. Iz tog razloga potreban nam je multidisciplinarni pristup i efikasni biomarkeri. Acidoalkoholno rezistentni bacilli (AARB), kulture i patohstološki nalaz biopsije kod većine pacijenata su pozitivni samo u manje od 10%. Za rezultate Lovenstein kulture potrebno je vreme od oko 6-8 nedelja, što odlaže dijagnozu. Adenozin deaminaza (ADA) je biomarker visoke osetljivosti i specifičnosti (više od 90%) i smatra se zlatnim standardom biomarkera u dijagnozi TP. Veoma je teško razlikovati maligni od TP sa limfocitnom predominacijom u punktatu, ali kod pacijenata sa malignim pleuralnim izlivom nivo ADA je smanjen, za razliku od TP. ADA u pleuralnom punktatu je brz, jednostavan, efikasan i ekonomičan način za razjašnjavanje etiologije pleuralnog izliva kao što je tuberkulozni pleuritis. Takođe, mnoge studije su dokazale ulogu ADA u proceni odgovora na lečenje tuberkuloze u periodu praćenja

Reference


1.      Jany B, Welte T. Pleural Effusion in Adults-Etiology, Diagnosis, and Treatment. DtschArztebl Int. 2019 May 24;116(21):377-386 Frost N et al. Indwelling pleural catheters for non-malignant pleural effusions: report on a single centre's 10 years of experience. BMJ Open Respir Res 2020; 7.


2.      Frost N et al. Indwelling pleural catheters for non-malignant pleural effusions: report on a single centre's 10 years of experience. BMJ Open Respir Res 2020; 7.


3.      Huyen PT et al. Exploring the value of pleural fluid biomarkers for complementary pleural effusion disease examination. Computational Biology and Chemistry. Volume 94, October 2021, 107559


4.      Porcel JM. Biomarkers in the diagnosis of pleural diseases: a 2018 update. TherAdvRespir Dis. 2018 Jan-Dec;12:1753466618808660


5.      Shaw JA, Koegelenberg CFN. Pleural Tuberculosis. Clin Chest Med. 2021 Dec;42(4):649-666.


6.      Shaw JA, Diacon AH, Koegelenberg CFN. Tuberculous pleural effusion. Respirology. 2019 Oct;24(10):962-971.


7.      Porcel JM. Pleural fluid biomarkers: beyond the Light criteria. Clin Chest Med. 2013 Mar;34(1):27-37


8.      Ren ZH, Xu L. Biomarkers of Distinguishing Neutrophil-Predominant Tuberculous Pleural Effusion from Parapneumonic Pleural Effusion. Am J Med Sci. 2021 Apr;361(4):469-478.


9.      Xi S, Sun J, Wang H, Qiao Q, He X. Diagnostic Value of Model-Based Iterative Algorithm in Tuberculous Pleural Effusion. J Healthc Eng. 2022 Feb 9;2022:7845767.


10.  Petborom P, Dechates B, Muangnoi P. Differentiating tuberculouspleuritis from other exudative lymphocytic pleural effusions. Ann Palliat Med. 2020 Sep;9(5):2508-2515


11.  Chen KY etal.Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion. Int Journal of Gen Medicine. 2016; 9: 183–189


12.  Lo Cascio CM, Kaul V, Dhooria S, Agrawal A, Chaddha U. Diagnosis of tuberculous pleural effusions: A review. Respir Med. 2021 Nov;188:106607.


13.  Ali MS, Light RW, Maldonado F. Pleuroscopy or video-assisted thoracoscopic surgery for exudative pleural effusion: a comparative overview. J Thorac Dis. 2019 Jul;11(7):3207-3216.


14.  Javadi J et al. Multiplex Soluble Biomarker Analysis from Pleural Effusion. Biomolecules 2020, 10, 1113


15.  Aggarwal AN, Agarwal R, Sehgal IS, et al..Adenosine deaminase for diagnosis of tuberculous pleural effusion: a systematic review and meta-analysis. PLoS One. 2019;14(3):e0213728


16.  Na F, Wang Y, Yang H, Guo L, Liang X, Liu D, Zhang R. Performance of adenosine deaminase in detecting paediatric pleural tuberculosis: a systematic review and meta-analysis. Ann Med. 2022 Dec;54(1):3129-3135.


17.  Gao L, Wang W, Zhang Y, Hu X, An J, Li Y et al. Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study. Ther Adv Respir Dis. 2023;17:17534666231155747.


18.  Lee J, Park JE, Choi SH, Seo H, Lee SY, Lim JK, Yoo SS, Lee SY, Cha SI, Park JY, Kim CH. Laboratory and radiological discrimination between tuberculous and malignant pleural effusions with high adenosine deaminase levels. Korean J Intern Med. 2022 Jan;37(1):137-145.


19.  Zeng T, Ling B, Hu X, Wang S, Qiao W, Gao L, Shen Y, Li D. The Value of Adenosine Deaminase 2 in the Detection of Tuberculous Pleural Effusion: A Meta-Analysis and Systematic Review. Can Respir J. 2022 Sep 10;2022:7078652.


20.  Kim SB, Shin B, Lee JH, Lee SJ, Lee MK, Lee WY et al. Pleural fluid ADA activity in tuberculous pleurisy can be low in elderly, critically ill patients with multi-organ failure. BMC Pulm Med. 2020;20(1):13.


21.  Kim HW, Kim KH, Shin AY, Choi JY, Ahn JH, Kim JS et al. Investigating the appropriate adenosine deaminase cutoff value for the diagnosis of tuberculous pleural effusion in a country with decreasing TB burden. Sci Rep. 2022;12(1):7586.


22.  Shaw JA, Irusen EM, Diacon AH, Koegelenberg CF. Pleural tuberculosis: A concise clinical review. ClinRespir J. 2018 May;12(5):1779-1786.


23.  Lin L, Li S, Xiong Q, Wang H. A retrospective study on the combined biomarkers and ratios in serum and pleural fluid to distinguish the multiple types of pleural effusion. BMC Pulm Med. 2021;21(1):95.


24.  Soedarsono S, Prinasetyo KWAI, Tanzilia M, Nugraha J. Changes of serum adenosine deaminase level in new cases of pulmonary tuberculosis before and after intensive phase treatment. Lung India. 2020;37(2):126-129.


25.  Saini V, Lokhande B, Jaswal S, Aggarwal D, Garg K, Kaur J. Role of serum adenosine deaminase in pulmonary tuberculosis. Indian J Tuberc. 2018 Jan;65(1):30-34.


 

Objavljeno
2023/05/11
Broj časopisa
Vol. 42 Br. 4 (2023): Journal of Medical Biochemistry
Rubrika
Short Communication

Sva prava zadržana (c) 2023 Jelena Janković, Branislav Ilic, Nataša Đurđević, Aleksandar Jandric

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