Značaj Galaktina-3 i N-terminalnog pro B-tipa natruretskog peptida u predviđanju atrijalne fibrilacije nakon kardiohirurške procedure

Bimarkeri i postoperativna atrijalna fibrilacija

  • Nikola Mladenović Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia
  • Ranko Zdravković Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija
  • Lazar Velicki Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija
  • Vanja Dljević Todić Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija
  • Mirko Todić Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija
  • Srđan Maletin Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija
  • Aleksandra Mladenović Institut za kardiovaskularne bolesti Vojvodine, Sremska Kamenica, Srbija
  • Nemanja Petrović Institut za kardiovaskularne bolesti Vojvodine, Sremska Kamenica, Srbija
  • Bogdan Okiljević Institut za kardiovaskularne bolesti Dedinje, Beograd, Srbija
  • Valentina Nikolić Univerzitet Niš, Medicinski fakultet, Niš, Srbija
  • Milan Pavlović Univerzitet Niš, Medicinski fakultet, Niš, Srbija
  • Dane Krtinić Univerzitet Niš, Medicinski fakultet, Niš, Srbija
  • Aleksandar Nikolić Univerzitet Niš, Medicinski fakultet, Niš, Srbija
  • Marko Gmijović Univerzitet Niš, Medicinski fakultet, Niš, Srbija
  • Aleksandar Kamenov Univerzitet Niš, Medicinski fakultet, Niš, Srbija
DOI: https://doi.org/10.5937/jomb0-47001
Ključne reči: Postoperativna atrialna fibrilacija, Kardiohirurgija, Galektin-3, NT-proBNP

Sažetak


Uvod: Postoperativna atrijalna fibrilacije (POAF) je učestala komplikacija nakon kardiohirurških procedura. Povezana je sa produženim hospitalnim lečenjem, povećanim morbiditetom, stopom mortaliteta i finansiskim troškovima. Cilj rada je bio da se utvrdi povezanost nivoa Galektina-3 i N-terminalnog pro-B-tipa natriuretskog peptida (NT-proBNP) sa POAF nakon kardiohirurške operacije.

Pacijenti i metode: Prospektivna studija obuhvata bolesnike starosti od 18-85 godina, hospitalizovanih radi elektivne operacije aorto koronarnog bajpasa (CABG) ili CABG sa zamenom aortnog zaliska. Nivoi Galektina-3 i NT-proBNP iz krvi mereni su preoperativno i postoperativnog 1. i 7. dana.

Rezultati: U istraživanju je uključeno 103 bolesnika. PAOF je zabeležena kod 45 bolesnika. Prosečna starost bolesnika kod kojih je registrovan POAF bila je 68,8 godina, dok je kod ostalih bila 65,5 godina (n=0,028). Nivoi Galektina-3 i NT-proBNP nisu se razlikovali kod bolesnika koji su razvili POAF, a ni kod onih kojima nije registrovana POAF u sva tri merenja. Promene nivoa Galektin-3 prvog postoperativnog dana imaju statistički značajnu vrednost za predviđanje POAF (AUC=0.627 [0.509-0.745], p<0.05). Smanjenje nivoa Galektina-3 prvog postoperativnog dana za preko 17% dovodi do povećanog rizika od razvoj POAF .

Zaključak: Preoperativne vrednosti Galektina-3 i NT-proBNP nisu povezani sa razvojem POAF nakon kardiohirurške intervencije. Jedina povezanost koju smo zabeležili je da smanjene vrednosti Galektina-3 prvog postoperativnog dana za preko 17% mogu biti prediktor za POAF.

Biografije autora

Ranko Zdravković, Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija

Asistent na predmetu Anesteziologija sa reanimatologijom.

Lazar Velicki, Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija

Profesor na katedri za Hirurgiju.

Vanja Dljević Todić, Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija

Asistent na katedri za Internu medicinu.

Mirko Todić, Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija

Asisten na katedri za Internu medicinu

Srđan Maletin, Univeryitet Novi Sad, Medicinski fakultet, Novi Sad, Srbija

Asistent na katedri za Internu medicinu

Aleksandra Mladenović, Institut za kardiovaskularne bolesti Vojvodine, Sremska Kamenica, Srbija

Lekar na klinici za Kardiovaskularnu hirurgiju

Nemanja Petrović, Institut za kardiovaskularne bolesti Vojvodine, Sremska Kamenica, Srbija

Lekar na Klinici za Kardiovaskularnu hirurgiju.

Bogdan Okiljević, Institut za kardiovaskularne bolesti Dedinje, Beograd, Srbija

Kardiohirurg

Valentina Nikolić, Univerzitet Niš, Medicinski fakultet, Niš, Srbija

Profesor na katedri za Farmakologiju

Milan Pavlović, Univerzitet Niš, Medicinski fakultet, Niš, Srbija

Profesor na katedri Interne medicine

Dane Krtinić, Univerzitet Niš, Medicinski fakultet, Niš, Srbija

Docent na katedri za Farmakologiju

Aleksandar Nikolić, Univerzitet Niš, Medicinski fakultet, Niš, Srbija

Asistent na katedri za Anestezilogiju i renimatologiju

Marko Gmijović, Univerzitet Niš, Medicinski fakultet, Niš, Srbija

Asistent na katedri za Hirurgiju

Aleksandar Kamenov, Univerzitet Niš, Medicinski fakultet, Niš, Srbija

Asistent na katedri ya Hirurgiju

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Objavljeno
2023/12/12
Broj časopisa
Vol. 43 Br. 3 (2024): Journal of Medical Biochemistry
Rubrika
Original paper

Sva prava zadržana (c) 2023 Nikola Mladenovic, Ranok Zdravkovic, Lazar Velicki, Vanja Drljevic Todic, Mirko Todic, Srdjan Maletin, Aleksandra Mladenovic, Nemanja Petrovic, Bogdan Okiljevic, Valentina Nikolić, Milan Pavlovic, Dane Krtinic, Aleksandar Nikolic, Marko Gmijovic, Aleksandar Kamenov

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