Adipokini i njihova uloga u akutnom pankreatitisu

Adipokini u akutnom pankreatitisu

  • Saira Rafaqat
  • Irena Radoman Vujacic Clinical Center of Montenegro, Department of Internal Medicine, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro
  • Dimitrios Patoulias
  • Huma Khurshid
  • Aleksandra Klisic

Sažetak


Akutni pankreatitis (AP) se karakteriše inflamatornim odgovorom koji vodi edemu i hemoragiji tkiva pankreasa. U težim stanjima može voditi i nekrozi pankreasa. Adipokini su biološki aktivni molekuli koje sekretuje masno tkivo, a koji imaju širok spektar dejstva. Adipokini i citokini nisu samo produkt belog masnog tkiva, već i masnog tkiva koje okružuje pankreas, igrajući važnu ulogu u inflamatornom odgovoru organizma. Prisustvo uvećanog masnog tkiva, često povezano sa gojaznošću, dovodi se u vezu sa pojačanim inflamatornim odgovorom u slučajevima AP. Podaci iz literature ukazuju na veliki broj otkrivenih adipokina. Ovaj revijski članak predstavlja prikaz uloge pojedinih adipokina u AP. Adipokini mogu biti obećavajući dijagnostički i terapijski biomarkeri u AP. Ipak, potrebna su dublja saznanja o signalnim putevima adipokina i potencijalnoj terapijskoj ulozi ovih biomarkera u AP.

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Objavljeno
2024/01/08
Rubrika
Review article