Korelacija GLUT4, LEPR i TNF-α sa endometrijskom recepcijom u ženama s policističnim jajničkim sindromom indukovanom nepristojenošću

  • Yan Dong Department of Obstetrics and Gynecology,The Second Hospital Affiliated of Shandong University of Traditional Chinese Medicine
  • Wei Department of Reproductive Medical Center,The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine
  • Yifei Department of Obstetrics and Gynecology,The Second Hospital Affiliated of Shandong University of Traditional Chinese Medicine
  • Yan Liu Department of Reproductive Medical Center,The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine
  • Lin Department of Reproductive Medical Center,The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine
  • Yan Li Department of Reproductive Medical Center,The Second Hospital Affiliated to Shandong University of Traditional Chinese Medicine
DOI: https://doi.org/10.5937/jomb0-51125
Ključne reči: Transporter glukoze 4, Leptinski receptor, faktor-α tumora nekroze, Policistički jajnički sindrom, nepristojnost

Sažetak


Cilj: Analizirati korelaciju glukoznog transportera 4 (GLUT4), receptora leptina (LEPR) i faktora tumora nekroze-α (TNF-α) sa endometrijskim receptivom u pacijenata s policističnim jajničkim sindromom (PCOS)-indukovanom nepristojnošću, kako bi pružili klinički dokaz za buduću dijagnozu i liječenje nepristojnosti indukovane na PCOS-u.

Metode: 46 pacijenata s nepristojnošću indukovanih PCOS-a priznanih u našu bolnicu od juna 2020. do avgusta 2023 (istraživačka grupa), kao i 35 istovremenih slučajeva jednostavnih PCOS-a (kontrolne grupe) i 32 zdravih žena (normalne grupe) izabrani su kao učesnici istraživanja. U svim sudionicima je otkrivena periferalna krvna nivoa GLUT4, LEPR i TNF-α, a analizirana je dijagnostična vrijednost troje za PCOS u zdravim ženama i za nepristojnost indukovane na PCOS-u bolesnika PCOS-a. Osim toga, izmjerili su endometrijsku debljinu i indeks pulsiranja endometrijskog toka krvi (PI) i indeks otpora (RI) pacijenata u istraživačkoj grupi, a razgovarali su o korelaciji GLUT4, LEPR i TNF-α sa endometrijskom recepcijom. Rezultati: GLUT4 je bio niži u istraživačkoj skupini u usporedbi s kontrolom i normalnim grupama, dok su LEPR i TNF-α bili veći (P<0,05); the control group showed lower GLUT4 and higher LEPR and TNF-α levels than the normal group (P<0.05).  Dijagnozna osjetljivost i specifičnost kombinovanog ispitivanja GLUT4, LEPR i TNF-α u ženama PCOS-indukovanoj nespoložnosti bila su 88,57% i 75,00%, a one za PCOS-e u zdravim ženama bile su 78,57% i 60,00%, odnosno (P<0,05). U istraživačkoj grupi, GLUT4 je pozitivno povezan sa endometrijskom debelom i negativno povezanom sa RI i PI-om; dok su LEPR i TNF-α negativno povezani sa endometrijskom debelom i pozitivno povezanim sa RI i PI (P<0,05). Zaključaci: GLUT4, LEPR i TNF-α su bliski povezani sa endometrijskom recepcijom u pacijenata s nepristojnošću indukovanih na PCOS-u, a njihovo kombinirano detektivo može efektivno proceniti pojavljivanje PCOS-a i nepristojnosti indukovanih na PCOS-u.

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Objavljeno
2024/09/11
Broj časopisa
Ahead of print
Rubrika
Original paper

Sva prava zadržana (c) 2024 Yan Dong, Wei Kong, Yifei Li, Yan Liu, Lin Li, Yan Li

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