Istraživanje nedostatka 25-hidroksivitamina D kod zdravih odraslih osoba starosti 18-65 godina u Istanbulu.
Istraživanje nedostatka 25-hidroksi vitamina D kod zdravih odraslih osoba
Sažetak
Pozadina: Odrediti prevalenciju nedostatka 25-hidroksi vitamina D (25(OH)D) kod zdravih odraslih pacijenata koji su se javili našoj bolnici u provinciji Istanbul i predstaviti razliku između nivoa vitamina 25(OH)D prema polu, starosnoj grupi , godišnje doba i mesec.
Materijali i metode: Retrospektivno su analizirani nivoi vitamina 25(OH)D kod 9.778 odraslih koji su se javili na internu ambulantu naše bolnice u periodu od januara 2022. do decembra 2023. godine. Pojedinci sa hroničnim poremećajima isključeni su iz studije. Odrasli pacijenti uključeni u studiju podeljeni su u dve grupe prema starosti (18-50 i 51-65 godina). Nivoi 25(OH)D u serumu mereni su metodom elektrohemiluminiscentnog imunoeseja. Nivo 25(OH)D u serumu smatran je deficitarnim ako je ispod 20 ng/mL, nedovoljnim ako je 20-30 ng/mL i dovoljnim ako je iznad 30 ng/mL. Nivoi 25(OH)D pacijenata su ispitivani prema starosti, polu, godišnjem dobu i mesecu.
Rezultati: Nakon merenja, nivoi vitamina D su bili deficitarni kod 57,2% pacijenata (n=5.592), nedovoljni kod 28.2% (n=2.756), a dovoljni kod 14.6% (n=1.430). Prosečan nivo vitamina D u starosnoj grupi od 18-50 godina bio je značajno niži nego u starosnoj grupi 51-65 (p=0,001; p<0,01). Nivo vitamina D se nije statistički značajno razlikovao prema polu (p=0,085, p>0,05). Srednji nivoi vitamina D bili su 17,99±10,88 ng/mL zimi, 18,11±12,69 ng/mL u proleće, 22,08±11,58 ng/mL leti i 21,67±10,82 ng/mL u jesen. Postojale su statistički značajne razlike prema sezoni i mesecu bolničke prezentacije (p=0,001; p<0,01).
Zaključak: Prevalencija nedostatka vitamina D (ispod 20 ng/mL) kod zdravih odraslih osoba starosti 18-65 godina u Istanbulu iznosila je 57,2%. Ova prevalencija je varirala u zavisnosti od godišnjih doba i meseci, što ukazuje da se sunčeva svetlost ne koristi dovoljno. Nedostatak vitamina D u Istanbulu predstavlja veliki problem koji treba otkloniti.
Reference
2- Vogeser M. Quantification of circulating 25-hydroxyvitamin D by liquid chromatography-tandem mass spectrometry. Journal of Streoid Biochemistry&Moleculer Biology
2010; 121: 565-73.
3- Moy FM, Bulgiba A. High prevalence of vitamin D insufficiency and its association with obesity and metabolic syndrome among Malay adults in Kuala Lumpur, Malaysia. Public Health 2011; 11:735.
4- Meer IM, Middelkoop BJC, Boeke AJP, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and sub-Sahara African populations in Europe and their countries of origin: an overview. Osteoporos Int2011; 22:1009-21.
5- Shea MK, Houston DK, Tooze JA, et al. Correlates and prevalence of insufficient 25-hydroxyvitamin D status in black and white older adults: The health, aging and body composition study. J Am Geriatr Soc 2011; 59:1165-74.
6- Antonucci, R., C. Locci, M. G. Clemente, E. Chicconi, and L. Antonucci. 2018. Vitamin D deficiency in childhood: Old lessons and current challenges. Journal of Pediatric Endocrinology & Metabolism: JPEM 31 (3):247–60. doi: 10.1515/jpem-2017-0391
7- Mallah EM, Hamad MF, Elmanaseer MA, Qinna NA, et al. Plasma concentrations of 25- hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status. Clinical Pathology 2011; 11:8.
8- Vu LH, Whiteman DC, Pols JC, Kimlin MG, Neale RE. Serum vitamin D levels in office workers in a subtropical climate. Photochemistry and Photobiology 2011; 87:
714-20.
9- Nanri A., Foo LH, Nakamura K, et al. Serum 25-hydroxyvitamin D concentrations and season- specific correlates in Japanese adults. J Epidemiol 2011; JE20100161.
10- Kaehler ST, Baumgartner H, Jeske M, et al. Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession. Eur
J Nutr 2011; 11:281-5.
11- Amrein, K., M. Scherkl, M. Hoffmann, S. Neuwersch-Sommeregger, M. Köstenberger, B. A. Tmava, G. Martucci, S. Pilz, and O. Malle. 2020. Vitamin D deficiency 2.0: An update on the current status worldwide. European Journal of Clinical Nutrition 74 (11):1498–513. doi: 10.1038/s41430-020- 0558-y
12- Lips P. Vitamin D status and nutrition in Europe and Asia. Journal of Steroid Biochemistry&Moleculer Biology 2007; 103:620-5.
13- Schoor MN, Lips P. Worldwide vitamin D status. Best Practice&Research Clinical Endocrinology&Metabolism 2011; 25:671-80.
14- Płudowski, P.; Karczmarewicz, E.; Bayer, M.; Carter, G.; Chlebna-Sokół, D.; Czech-Kowalska, J.; D ˛ebski, R.; Decsi, T.; Dobrza ´nska, A.; Franek, E.; et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe Recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol. Pol. 2013, 64, 319–327
15- Prentice A.Vitamin D deficiency: a global perspective Nutrition Reviews® Vol. 66(Suppl. 2):S153–S164 doi:10.1111/j.1753-4887.2008.00100.x
16- Bouillon, R., and G. Carmeliet. 2018. Vitamin D insufficiency: Definition, diagnosis and management. Best practice & research. Best Practice & Research. Clinical Endocrinology & Metabolism 32 (5):669–84. doi: 10.1016/j.beem.2018.09.014
17- Hansen, J. P., M. Pareek, A. Hvolby, A. Schmedes, T. Toft, E. Dahl, and C. T. Nielsen. 2019. Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep). BMC Research Notes 12 (1):4218. doi: 10.1186/s13104-019-4218-z.
18- Płudowski, P.; Kos-Kudła, B.; Walczak, M.; Fal, A.; Zozuli ´nska-Ziółkiewicz, D.; Sieroszewski, P.; Peregud-Pogorzelski, J.; Lauterbach, R.; Targowski, T.; Lewi ´nski, A.; et al. Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland. Nutrients 2023, 15, 695. https://doi.org/ 10.3390/nu15030695
19- Giustina, A., R. A. Adler, N. Binkley, R. Bouillon, P. R. Ebeling, M. Lazaretti-Castro, C. Marcocci,
R. Rizzoli, C. T. Sempos, and J. P. Bilezikian. 2019. Controversies in vitamin D: Summary statement from an international conference. The Journal of Clinical Endocrinology and Metabolism 104 (2):234– 40. doi: 10.1210/jc.2018-01414.
20- Cashman, K. D., K. G. Dowling, Z. Škrabáková, M. Gonzalez-Gross, J. Valtueña, S. De Henauw, L. Moreno, C. T. Damsgaard, K. F. Michaelsen, C. Mølgaard, et al. 2016. Vitamin D deficiency in Europe: Pandemic? The American Journal of Clinical Nutrition 103 (4):1033–44. doi: 10.3945/ajcn.115.120873.
21- Larose TL, Chen Y, Camargo CA Jr, Langhammer A, Romundstad P, Mai XM.. Factors associated with vitamin Ddeficiency in a Norwegian population: the HUNT Study. J Epidemiol Community Health. 2014;68:165–70. [PubMed]
22- Kull M Jr, Kallikorm R, Tamm A, Lember M.. Seasonal variance of 25-(OH) vitamin D in the general population of Estonia, a Northern European country. BMC Public Health. 2009;9:22. [PMC free article] [PubMed] [Google Scholar]
23 Burnand B, Sloutskis D, Gianoli F, Cornuz J, Rickenbach M, Paccaud F. et al. Serum 25- hydroxyvitamin D:distribution and determinants in the Swiss population. Am J Clin Nutr. 1992;56:537–
42. [PubMed] [Google Scholar]
24- Burgaz A, Akesson A, Oster A, Michaelsson K, Wolk A.. Associations of diet, supplement use, and ultraviolet Bradiation exposure with vitamin D status in Swedish women during winter. Am J Clin Nutr. 2007;86:1399–404.
25- Gois P, Ferreira D, Olenski S, Seguro A. Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor. Nutrients 2017;9:651.
26- 26Büyükdere Y, Ayaz A. Evaluation of the association between tuberculosis and vitamin d: current approaches. Sakarya Med J 2019;9:565-73
27--Öğüş E, Sürer H, Kılınç AŞ, Fidancı V, Yılmaz G, Dindar N, et al. Evaluation of vitamin D levels by months, sex and age. Ankara Med J 2015;15:1-5.
28- Alayunt NO, Özüdoğru O.Changes in Vitamin D Levels According to Age, Gender and Season in the Siirt Province. Turk J Osteoporos 2020;26:160-4
29- Hekimsoy Z, Dinc G, Kafesciler S, Onur E, Guvenc Y, Pala T. et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;10:782. [PMC free article] [PubMed] [Google Scholar]
30- Bolland MJ, Grey AB, Ames RW, Mason BH, Horne AM, Gamble GD, et al. The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. Am J Clin Nutr 2007;86:959-64
31- Alfawaz H, Tamim H, Alharbi S, Aljaser S, Tamimi W.. Vitamin D status among patients visiting a tertiary care center in Riyadh, Saudi Arabia: a retrospective review of 3475 cases. BMC Public Health. 2014;14:159. [PMC free article] [PubMed] [Google Scholar]
32 -G R, Gupta A.. Vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients. 2014;6:729–75. [PMC free article] [PubMed] [Google Scholar]
33- Nimitphong H, Holick MF.. Vitamin D status and sun exposure in southeast Asia. Dermatoendocrinol. 2013;5:34–7. [PMC free article] [PubMed] [Google Scholar
Sva prava zadržana (c) 2024 Gozde Ulfer
Ovaj rad je pod Creative Commons Autorstvo 4.0 međunarodnom licencom.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.