Статус витамина Д међу трудницама Северне Македоније: процена стопе недостатка и придруженог фактора ризика

Концентрација витамина Д међу трудницама Северне Македоније

  • Aleksandra Atanasova Boshku 1University Clinic of Obstetrics and Gynecology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia
DOI: https://doi.org/10.5937/jomb0-55601
Ključne reči: 25(ОХ) витамин Д, жена, трудноћа, недостатак, суплементација

Sažetak


Циљ. Витамин Д је есенцијални витамин који игра кључну улогу у одржавању укупног здравља. Током трудноће, потражња за витамином Д се повећава како би се подржале растуће потребе фетуса. Недостатак витамина Д је веома распрострањен код трудница широм света. Циљ нашег истраживања био је да се процени стопа недостатка витамина Д код трудница у Републици Северној Македонији, заједно са факторима утицаја. Материјали и методе: Спровели смо проспективну студију на случајно одабраним трудницама са различитим индексом телесне масе иу две различите сезоне међу корисницима и не-корисницама витаминских суплемената. Резултати: Укупно 309 трудница старијих од 18 година регрутовано је од августа 2022. до јануара 2023. године, са просечном концентрацијом витамина Д од 38,9 (36,6-40,2) нмол/л. У зимском периоду 80,8% трудница имало је недостатак витамина Д. Закључак: Упркос чињеници да више од 77,3% трудница конзумира мултивитамине који садрже витамин Д, недостатак витамина Д је веома распрострањен међу трудницама, посебно међу трудницама и током зимских месеци.

Reference

1. Maternal and child nutrition.pdf [Internet]. [cited 2024 Oct 4]. Available from: https://www.nice.org.uk/guidance/ph11/resources/maternal-and-child-nutrition-pdf-1996171502533
2. Karras SN, Wagner CL, Castracane VD. Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes. Metabolism. 2018 Sep;86:112–23.
3. Agarwal S, Kovilam O, Agrawal DK. Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review. Crit Rev Food Sci Nutr. 2018 Mar 24;58(5):755–69.
4. Bärebring L, Bullarbo M, Glantz A, Hulthén L, Ellis J, Jagner Å, et al. Trajectory of vitamin D status during pregnancy in relation to neonatal birth size and fetal survival: a prospective co-hort study. BMC Pregnancy Childbirth. 2018 Feb 13;18(1):51.
5. Aghajafari F, Field CJ, Kaplan BJ, Rabi DM, Maggiore JA, O’Beirne M, et al. The Current Recommended Vitamin D Intake Guideline for Diet and Supplements During Pregnancy Is Not Adequate to Achieve Vitamin D Sufficiency for Most Pregnant Women. PLoS ONE. 2016 Jul 1;11(7):e0157262.
6. Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal out-comes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015 May;103(5):1278-1288.e4.
7. Karras SN, Fakhoury H, Muscogiuri G, Grant WB, van den Ouweland JM, Colao AM, et al. Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug 1;8(4):124–35.
8. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D [Internet]. Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Washington (DC): National Acad-emies Press (US); 2011 [cited 2024 Oct 4]. (The National Academies Collection: Reports funded by National Institutes of Health). Available from: http://www.ncbi.nlm.nih.gov/books/NBK56070/
9. World Health Organization. Guideline: vitamin D supplementation in pregnant women [Inter-net]. Geneva: World Health Organization; 2012 [cited 2024 Oct 4]. Available from: https://iris.who.int/handle/10665/85313
10. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Dietary reference values for vitamin D. EFSA J. 2016;14(10):e04547.
11. nhs.uk [Internet]. 2020 [cited 2024 Oct 4]. Vitamins, minerals and supplements in pregnancy. Available from: https://www.nhs.uk/pregnancy/keeping-well/vitamins-supplements-and-nutrition/
12. Dovnik A, Mujezinović F, Treiber M, Pečovnik Balon B, Gorenjak M, Maver U, et al. Deter-minants of maternal vitamin D concentrations in Slovenia: A prospective observational study. Wien Klin Wochenschr. 2017 Jan;129(1–2):21–8.
13. Djekic-Ivankovic M, Weiler H, Jones G, Kaufmann M, Kaludjerovic J, Aleksic-Velickovic V, et al. Vitamin D status in mothers with pre-eclampsia and their infants: a case–control study from Serbia, a country without a vitamin D fortification policy. Public Health Nutr. 2016 Apr 18;1:1–11.
14. Borissovа AM, Trifonova B, Dakovska L, Mihailova E, Vukov M. Vitamin D Supplementa-tion for Pregnant Women in Bulgaria. Eur J Prev Med. 2020 Aug 18;8:56.
15. Xyda SE, Kotsa K, Doumas A, Papanastasiou E, Garyfallos AA, Samoutis G. Could the Ma-jority of the Greek and Cypriot Population Be Vitamin D Deficient? Nutrients. 2022 Sep 13;14(18):3778.
16. Sideri V, Antonakos G, Fretzayas A, Attilakos A, Chrelias C, Papaevangelou V, et al. Hypo-vitaminosis D in Healthy Pregnant Women and their Newborns in Greece. Endocr Metab Im-mune Disord Drug Targets. 2019;19(2):159–65.
17. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.
18. Kimball SM, Holick MF. Official recommendations for vitamin D through the life stages in developed countries. Eur J Clin Nutr. 2020 Nov;74(11):1514–8.
19. Amrein K, Scherkl M, Hoffmann M, Neuwersch-Sommeregger S, Köstenberger M, Tmava Berisha A, et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020;74(11):1498–513.
20. Xyda SE, Kotsa K, Doumas A, Papanastasiou E, Garyfallos AA, Samoutis G. Could the Ma-jority of the Greek and Cypriot Population Be Vitamin D Deficient? Nutrients. 2022 Sep 13;14(18):3778.
21. Czech-Kowalska J, Gruszfeld D, Jaworski M, Bulsiewicz D, Latka-Grot J, Pleskaczynska A, et al. Determinants of Postpartum Vitamin D Status in the Caucasian Mother-Offspring Pairs at a Latitude of 52°N: A Cross-Sectional Study. Ann Nutr Metab. 2015;67(1):33–41.
22. Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, et al. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS-2020 UPDATE. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2020 May;26(Suppl 1):1–46.
23. Meija L, Piskurjova A, Nikolajeva K, Aizbalte O, Rezgale R, Lejnieks A, et al. Vitamin D Intake and Serum Levels in Pregnant and Postpartum Women. Nutrients. 2023 Jan;15(15):3493.
24. Hitrova-Nikolova S, Koleva L, Georgieva S, Vakrilova L, Petkova V, Dimitrov M, et al. Vit-amin D Status in Term Newborns and Their Mothers. Proc Bulg Acad Sci. 2023 Apr 30;76(4):622–8.
25. Hauta-alus HH, Holmlund-Suila EM, Rita HJ, Enlund-Cerullo M, Rosendahl J, Valkama SM, et al. Season, dietary factors, and physical activity modify 25-hydroxyvitamin D concentration during pregnancy. Eur J Nutr. 2018 Jun;57(4):1369–79.
26. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017 Jun;18(2):153–65.
27. Lips P, de Jongh RT, van Schoor NM. Trends in Vitamin D Status Around the World. JBMR Plus. 2021 Nov 30;5(12):e10585.
28. Rupprecht M, Wagenpfeil S, Schöpe J, Vieth R, Vogt T, Reichrath J. Meta-Analysis of Euro-pean Clinical Trials Characterizing the Healthy-Adult Serum 25-hydroxyvitamin D Response to Vitamin D Supplementation. Nutrients. 2023 Sep 14;15(18):3986.
29. Holick MF. A Call to Action: Pregnant Women In-Deed Require Vitamin D Supplementation for Better Health Outcomes. J Clin Endocrinol Metab [Internet]. 2018 Sep 18 [cited 2024 Dec 1]; Available from: https://academic.oup.com/jcem/advance-article/doi/10.1210/jc.2018-01108/5098355
30. Polanek E, Sisák A, Molnár R, Máté Z, Horváth E, Németh G, et al. A Study of Vitamin D Status and Its Influencing Factors among Pregnant Women in Szeged, Hungary: A Secondary Outcome of a Case-Control Study. Nutrients. 2024 May 9;16(10):1431.
31. Tsenkova-Toncheva L, Hristova-Atanasova E, Iskrov G, Stefanov R. Prenatal Vitamin D De-ficiency and Maternal and Fetal Health Outcomes. Cureus. 16(9):e69508.
32. Abdelmageed RM, Hussein SMM, Anamangadan SM, Abdullah RWM, Rauf L, AlFehaidi AS, et al. Prospective cohort study of vitamin D deficiency in pregnancy: Prevalence and lim-ited effectiveness of 1000 IU vitamin D supplementation. Womens Health. 2024 Jan 1;20:17455057231222404.
Objavljeno
2025/04/16
Broj časopisa
Vol. 44 Br. 6 (2025): Journal of Medical Biochemistry
Rubrika
Original paper

Sva prava zadržana (c) 2025 Aleksandra Atanasova Boshku

Creative Commons License

Ovaj rad je pod Creative Commons Autorstvo 4.0 međunarodnom licencom.

The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.