Th17/Treg Cells and Inflammatory Factors in patients with Thoracolumbar Kyphosis due to Ankylosing Spondylitis: Changes Before and After Vertebral Column Decancellation and Their Relationship with Sagittal Balance
Sažetak
Objective: This study aimed to explore the impact of Th17/Treg cell imbalance and inflammatory factors (IL-1β, IL-18, and TNF-α) on sagittal balance in patients with thoracolumbar kyphosis due to ankylosing spondylitis (AS) following vertebral column decancellation (VCD).
Methods: A total of 134 AS patients undergoing VCD were enrolled and categorized into an imbalance group (46 cases) and a balance group (88 cases), depending on postoperative sagittal balance. Measurements of the Th17/Treg ratio and inflammatory factor levels were conducted at three time points: preoperatively (T0), 24 hours postoperatively (T1), and 4 weeks postoperatively (T2). These data were analyzed alongside sagittal parameters (SVA, PI-LL, and PT) to assess their correlations and predictive potential.
Results: At 4 weeks after surgery, the imbalance group showed significantly elevated Th17/Treg ratios and higher levels of IL-1β, IL-18, and TNF-α compared to the balance group (P<0.05). Th17/Treg, IL-1β, IL-18, and TNF-α were positively correlated with SVA, PI-LL, and PT (P<0.05). Notably, the combined assessment of Th17/Treg ratio and inflammatory facto52.17% and specificity of 90.91%.
Conclusion: The findings suggest that Th17/Treg imbalance and excessive expression of IL-1β, IL-18, and TNF-α are strongly linked to postoperative sagittal imbalance in AS patients. These biomarkers may serve as valuable early predictors for assessing surgical outcomes.
Sva prava zadržana (c) 2025 Yan Wang, Jin Du, Tianhao Wang, Chao Xue, Guoquan Zheng
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