Oxidative Stress Modulation in Type 2 Diabetes: Insights from Metformin and Pioglitazone Therapy
Oxidative Stress in T2DM: Metformin and Pioglitazone
Sažetak
This commentary critically examines a recent study that assessed the effects of metformin and pioglitazone on oxidative stress in patients with type 2 diabetes mellitus. The original study utilized multiple biomarkers such as IMA, TOS, TAS, and OSI but observed only limited antioxidant effects and a rise in IMA levels. By referencing additional clinical trials, experimental studies, and reviews, this commentary emphasizes the importance of using broader biomarker panels, extending treatment duration, and interpreting oxidative stress markers with caution in diabetes research.
Reference
2. Balamurugan AN, Rema M, Mohan V. The protective role of pioglitazone on oxidative stress and inflammation in patients with type 2 diabetes mellitus. Indian J Med Res. 2013;137(1):124–129. PMID: 23328000.
3. Singh D, Behl T, Singh S, Sharma N, Malik S. Comparative evaluation of metformin and pioglitazone on oxidative stress in type 2 diabetes mellitus patients. Int J Basic Clin Pharmacol. 2016;5(4):1486–1490.
4. Mirmiranpour H, Mousavizadeh M, Noshad S, et al. Comparative effects of pioglitazone and metformin on oxidative stress markers in newly diagnosed type 2 diabetes patients: A randomized clinical trial. J Diabetes Complications. 2013;27(6):501–507.
5. Khan N, Kumar V, Arora R, et al. Pioglitazone and metformin synergistically attenuate oxidative stress and inflammation in a streptozotocin-induced rat model of diabetes. Life Sci. 2024;345:121107. PMID: 40563879.
6. Li J, Deng X, Zhao Y, et al. Combined treatment with metformin and pioglitazone improves mitochondrial function and reduces hepatic oxidative stress in a diabetic mouse model. Biomed Pharmacother. 2024;165:115251. PMID: 40563054.
7. Rizvi SI, Mishra M. Anti-oxidant effect of metformin: A review of recent findings. Biomed Pharmacother. 2012;66(6):405–410. PMID: 22411919.
8. Hu Y, Liu Y, He Y, et al. Effects of metformin on oxidative stress and antioxidant status in type 2 diabetic patients with or without poor glycemic control. J Diabetes Res. 2018;2018:1–8. PMID: 29221717.
9. Bulatova N, Al-Qudah A, Odeh A, et al. Impact of metformin and lifestyle modification on oxidative stress markers in patients with type 2 diabetes mellitus. Saudi Med J. 2018;39(2):144–151. PMID: 32769032.
10. Bar-Or D, Winkler JV, Vanbenthuysen K, et al. Reduced albumin cobalt binding with transient myocardial ischemia after elective percutaneous coronary intervention: a preliminary comparison to troponin I. Am Heart J. 2001;143(6):1053–1059. PMID: 11376305.
11. Guo X, Xu Y, He M, Du X, Zhang L, Li J, et al. Pioglitazone improves antioxidant status and insulin sensitivity in newly diagnosed type 2 diabetic patients. Diabetes Res Clin Pract. 2012;95(2):243–248. PMID: 22963881.
Sva prava zadržana (c) 2025 Seshadri Reddy Varikasuvu
Ovaj rad je pod Creative Commons Autorstvo 4.0 međunarodnom licencom.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.