PRIMENJIVOST FORMULA ZA IZRAČUAVANJE LDL-HOLESTEROLA U HIPERTRIGLICERIDEMIJI: UVIDI IZ VOJVODINE

LDL-C FORMULE U HIPERTRIGLICERIDEMIJI

  • Dragana Žuvić Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0000-0002-0114-2989
  • Stanislava Nikolić Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0000-0002-7859-0923
  • Romana Mijović Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0000-0002-4034-1585
  • Branislava Ilinčić Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0000-0001-6160-8173
  • Aneta Ranđelović Živković Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0009-0008-9714-4831
  • Dušan Sedlarević Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0009-0008-2075-4754
  • Velibor Čabarkapa Medicinski fakultet, Univerzitet u Novom Sadu; Centar za laboratorijsku dijagnostiku, Univerzitetski klinički centar Vojvodine, Novi Sad, Srbija https://orcid.org/0000-0001-7166-3379
DOI: https://doi.org/10.5937/jomb0-61948
Ključne reči: lipidi; holesterol, LDL; hipertrigliceridemija; Sampson formula

Sažetak


Uvod: LDL-holesterol predstavlja ključni parametar u proceni rizika nastanka aterosklerotske kardiovaskularne bolesti. Određivanje LDL-holesterola direktnom metodom nije uvek moguće iz praktičnih ili finansijskih razloga, te izračunavanje putem formula ima značaj u njegovoj procenu. Cilj ovog istraživanja je bio da ispita primenljivost četiri različite formule za izračunavanje LDL-holesterola u odnosu na direktnu metodu kod pacijenata sa vrednostima serumskih triglicerida u između 4,5 do 9,0 mmol/L u populaciji Vojvodine.

Metode: Ovo istraživanje je sprovedeno kao retrospektivna studija koja je uključila 272 ispitanika kod kojih su određivani parametri lipidskog statusa u periodu od juna 2022 do juna 2023. godine. Ispitanici su imali vrednosti triglicerida u serumu od 4,5 do 9,0 mmol/L. LDL-holesterol je određivan direktnom metodom na Alinity c analizatoru (Abbott), a vrednosti LDL-holesterola su i izračunavane formulama koje su predložili Friedewald, Sampson, Anandaraja i Martin.

Rezultati: U ispitivanoj populaciji prosečna starost je bila 52 godine a medijana koncentracije triglicerida 5,48 mmol/L. Statistički značajna pozitivna korelacija postoji između direktno određivanog LDL-holesterola (d-LDL-C) i svih izračunatih vrednosti (p<0,001). Najmanja prosečna razlika je uočena između d-LDL-C i LDL-holesterola računatog po formuli Sampson i sar. (MD=-0,032). Poređenjem d-LDL-C i vrednosti LDL-holesterola dobijenih izračunavanjem, jedino formula Sampsona i sar. nije pokazala statističku značajnost razlika (p=0,240).

Zaključak: U ispitivanoj populaciji pacijenata sa hipertrigliceridemijom, formula Sampsona i saradnika je pokazala najbolje performanse u odnosu na ostale ispitivane te bi njena primena mogla biti razmotrena kod stanovništva Vojvodine.

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Objavljeno
2026/02/04
Broj časopisa
Ahead of print
Rubrika
Original paper

Sva prava zadržana (c) 2026 Dragana Žuvić, Stanislava Nikolić, Romana Mijović, Branislava Ilinčić, Aneta Ranđelović Živković, Dušan Sedlarević, Velibor Čabarkapa

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