KLINIČKI, PATOLOŠKI I TERAPIJSKI TOK BOLESTI KOD PACIJENTA SA POČETNOM DIJAGNOZOM METASTATSKOG  SETTLE TUMORA- PRIKAZ S

Nada Cicmil-Sarić

doi:10.5937/mckg49-9719

Nada Cicmil-Sarić Klinika za onkologiju i radioterapiju KCCG Podgorica

DOI: https://doi.org/10.5937/mckg49-9719

Abstract

Epitelijalni tumor vretenastih ćelija sa diferencijacijom sličnoj timusu (SETTLE ) je ekstremno rijedak tumor štitaste žlijezde za koji se smatra da se razvija iz škržne brazde ili ostataka timusa i koji pokazuje primitivnu diferencijaciju grudne žlijezde. Bio je spomenut 41 put do kraja juna 2015. u skladu sa dostupnom literaturom. Donosimo prikaz slučaja dvadesetrogodišnjeg muškarca u toku vremenskog praćenja od dvadeset i četiri mjeseca. Predstavljamo slučaj fokusirajući na patološku složenost i terapiju metastatske bolesti kod ovog rijetkog tumora. Ovo je prvi slučaj SETTLE tumora u Crnoj Gori. U trenutku postavljanja histopatološke dijagnoze SETTLE tumor je već bio u metastatskom stadijumu. Primarni tumor u štitastoj žlijezdi nikada nije pronađen.

Ključne riječi: timusu sličan, epitelijalni tumor vretenastih ćelija, metastaza

Author Biography

Nada Cicmil-Sarić, Klinika za onkologiju i radioterapiju KCCG Podgorica

Primarius,specijalista interne medicine,onkolog

References

Chan JK, Rosai J. Tumors of the neck showing thymic correlated branchial pouch differentiation: a unifying concept.Hum Pathol 1991;22:349 –367.

Harach HR, Saravia Day E, Franssila KO. Thyroid spindle-cell tumor with mucous cysts. An intrathyroid thymoma?Am J Surg Pathol 1985;9:525–530.

Kingsley DPE, Elton A, Bennett MH. Malignant teratoma of the thyroid: case report and a review of the literature. Br J Cancer 1968;22:7–11.

Levey M. An unusual thyroid tumor in a child. Laryngoscope 1976;86:1864 –1868.

Murao T, Nakanishi M, Toda K, Honishi H. Malignant teratoma of the thyroid gland in an adolescent female. Acta Pathol Jpn 1979;29:109 –117.

Weigensberg C, Dalsley H, Asa SL, Bedard YC, Mullen JBM. Thyroid thymoma in childhood. Endocr Pathol 1990;1:123–127.

Hofman P, Mainguene C, Michiels JF, Pages A, Thyss A. Thyroid spindle epithelial tumor with thymus-like differentiation (the “SETTLE” tumor). An immunohistochemical and electron microscopic study. Eur Arch Otorhinolaryngol 1995;252:316 –320.

Saw D, Wu D, Chess Q, Shemen L. Spindle epithelial tumor with thymus-like element (SETTLE), a primary thyroid tumor. Int J Surg Pathol 1997;4:169 –174.

Su L, Beals T, Bernacki EG, Giordano TJ. Spindle epithelial tumor with thymus-like differentiation: a case report with cytologic, histologic, immunohistologic, and ultrastructural findings. Mod Pathol 1997;10:510 – 514.

Chetty R, Goetsch S, Nayler S, Cooper K. Spindle epithelial tumour with thymus-like element (SETTLE): the predominantly monophasic variant. Histopathology 1998;33:71–74.

Bradford CR, Devaney KO, Lee JI. Spindle epithelial tumorwith thymus-like differentiation: a case report and review of the literature. Otolaryngol Head Neck Surg 1999;120:603– 606.

Kirby PA, Ellison WA, Thomas PA. Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid with prominent mitotic activity and focal necrosis. Am J SurgPathol 1999;23:712–716.

Cheuk W, Jacobson AA, Chan JK. Spindle epithelial tumor with thymus like differentiation (SETTLE): a distinctive malignant thyroid neoplasm with significant metastatic potential. Mod Pathol. 2000;13:1150-5.

Raffel A, Cupisti K, Rees M, Janig U, Bernbeck B, Jazbec J, et al. Spindle epithelial tu-