UTICAJ TOPIKALNIH HIPOTENZIVNIH LEKOVA NA REDUKCIJU PADA SENZITIVNOSTI VIDNOG POLJA USLED DRUZA GLAVE VIDNOG ŽIVCA - PRIKAZ SLUČAJA
PRIKAZ SLUCAJA
Ključne reči:
Ključne reči: druze glave vidnog živca, vidno polje, skotomi, hipotenzivni lek
Sažetak
SAŽETAK
Druze glave vidnog živca predstavljaju kongenitalnu anomaliju, formu kalcijumske degeneracije aksona glave optičkog nerva. Inicijalno su asimptomatske ali mogu biti i jedan od uzroka progresivne optičke neuropatije. Prezentuju se kao acelularni, hijalini depoziti globularnog izgleda u prelaminarnom segmentu glave vidnog živca. Nastaju usled: izmenjenog aksonalnog transporta, malog dijametra skleralnog kanala, direktne kompresije i ishemije. Komplikuju se progresivnim ispadima u vidnom polju, ishemičnom optičkom neuropatijom, okluzijom centralne retinalne arterije ili vene, peripapilarnom neovaskularizacijom. Dijagnostikuju se oftalmoskopijom, angiografijom, kompjuterizovanom perimetrijom, B-scan ultrasonografijom, CT, OCT, HRT, GDx, elektrofiziološkim ispitivanjem. Terapija je medikamentozna, laser, hirurška. Većina pilot studija potvrđuje benefit topikalnih hipotenzivnih lekova i kada druze nisu asocirane sa glaukomom. Sniženjem intraokularnog pritiska se smanjuje kompresija aksona vidnog živca i poboljšava reperfuzija. Rad prezentuje mladu pacijentkinju sa obostranim druzama vidnog živca, progresivnim skotomima, zbog čega je uključena topikalna hipotenzivna terapija. Nakon šest meseci redukovani su skotomi i gubitak senzitivnosti vidnog polja. Efekat neuroprotektivnih lekova se istražuje radi smanjenja potencijalnog morbiditeta.
Ključne reči: druze glave vidnog živca, vidno polje, skotomi, hipotenzivni lek
Reference
Literatura:
1. Morris RW, Ellerbrock JM, Hamp AM, Joy JT, Roels P, Davis CN Jr. Advanced visual field loss secondary to optic nerve head drusen: case report and literature review. Optometry. 2009 Feb;80(2):83-100.
2. Schargus M, Gramer E. Optic disc drusen. Ophthalmologe. 2008 Jul;105(7): 693-710.
3. Auw-Haedrich C, Staubach F, Witschel H. Optic disk drusen. Surv Ophthalmol. 2002 Nov-Dec;47(6):515-32.
4. Czajor K, Misiuk-Hojło M. Heidelberg Edge Perimetry in optic nerve drusen – a case report. MEDtube Science Mar, 2014; Vol.II (1)
5. Ubhi P, Shechtman D, Green K. Discern Optic Nerve Head Drusen from True Papilledema. Review of Optometry. Dec. 15, 2015.
6. Friedman AH, Henkind P, Gartner S. Drusen of the optic disc. A histopathological study. Trans Ophthalmol Soc U K. April 1975. 95 (1): 4–9.7. Chang MY, Pineles SL. Optic disk drusen in children. Surv Ophthalmol. 2016 Nov - Dec;61(6):745-758.
8. Gay D, Boyer S.Two differing presentations of optic nerve head drusen. Optometry. 2001. Sep;72(9): 588-96.
9. Davis PL, Jay WM. Optic nerve head drusen. Seminars in Ophthalmology. 2003.Vol. 18(4): 222–24210. Gili P, Flores-Rodríguez P, Yangüela J, Orduña-Azcona J, Martín-Ríos M. Evaluation of optic disc size in patients with optic nerve head drusen using fundus photography. J Optom. 2013. Apr; 6(2): 75–79.
11. Grippo TM, Rogers SW, Tsai JC. Optic Disc Drusen. Glaucoma Today. Jan/Feb 2012.
12. Gaillard F. Optic Disc Drusen. Available from: http:// radiopaedia.org. 2005-2017.
13. Aumiller MS. Optic disc drusen: complications and manage¬ment. Optometry. 2007; 78(1):10–16.
14. Jonas JB, Gusek GC, Guggenmoos Holzmann I, Naumann GO. Pseudopapilledema associated with abnormally small optic discs. Acta Ophthalmol. 1988;66(2):190-193.
15. GrippoTM, Shihadeh WA, Schargus M, Gramer E, Tello C et all. Optic Nerve Head Drusen and Visual Field Loss in Normotensive and Hypertensive Eyes. J Glaucoma 2008;17:100–104.
16. Kamjoo S, Epley KD, Pihlbad MS. Optic Disc Drusen. Available from: http://eyewiki.aao.org. January , 2015.
17. Gossman MV. Pseudopapilledema. Available from: http://emedicine.medscape.com. Oct, 2015.
18. Patel V, Oetting TA. Optic Nerve Drusen: 19-year-old female with blurred vision. EyeRounds.org. August 14, 2007; Available from: http://www.EyeRounds.org/cases.
19. Delyfer MN, Rougier MB, Fourmaux E, Cousin P, Korobelnik JF (April 2004). "Laser photocoagulation for choroidal neovascular membrane associated with optic disc drusen". Acta Ophthalmol Scand. 82 (2): 236–8.
20. Haritoglou C, Prieglinger SG, Grueterich M, Kampik A, Kriegelstein GK. Radial optic neurotomy for the treatment of acute functional impairment associated with optic nerve drusen.Br J Ophthalmol. 2005 Jun; 89(6): 779–780.
21. Pfriem M, Hoerauf H. Unsuccessful surgical excision of optic nerve drusen. Graefes Arch Clin Exp Ophthalmol. 2011. Oct; 249(10): 1583–1585.
22. Kapur R, Pulido JS, Abraham JL, Sharma M, Buerk B, Edward DP. Histologic findings after surgical excision of optic nerve head drusen. Retina. 2008. Jan; 28(1):143-6.
23. Pinxten I, Stalmans P. Radial optic neurotomy as a treatment for anterior ischemic optic neuropathy secondary to optic disc drusen. GMS Ophthalmol Cases; 2014. Jul 15;4.
24. Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GO. Optic nerve head drusen associated with abnormally small optic discs. Int Ophthalmol. 1987 Dec;11(2):79-82.
25. Wilkins J, Pomeranz H. Visual manifestations of visible and buried optic disc drusen. J
Neuroophthalmol. 2004;24(2):125-129.
26. Calvo-González C, Santos-Bueso E, Díaz-Valle D, Reche-Frutos J, Moriche-Carretero M, Benítez-Del-Castillo JM et all. Optic nerve drusen and deep visual fields defects. Arch Soc Esp Oftalmol. 2006 May;81(5):269-73.
27. Obuchowska I, Mariak Z. Visual field defects in the optic disc drusen. Klin Oczna. 2008;110(10-12):357-60.
28. Katz BJ, Pomeranz HD.Visual field defects and retinal nerve fiber layer defects in eyes with buried optic nerve drusen. Am J Ophthalmol. 2006 Feb;141(2):248-253.
29. Spalding JM. Visual-field loss with optic nerve drusen and ocular hypertension: a case report. Optometry. 2002 Jan;73(1):24-32.
30. Sowka J, Kabat A. IOP, Drusen and Occlusion. Rewiev of Optometry. Feb, 2016.31. Pojda-Wilczek D, Herba E, Jedrzejewski W, Pojda SM. Optic disc drusen and glaucoma--case report. Klin Oczna. 2004;106(1-2 Suppl):263-5.
32. Ziak P, Jarabáková K, Koyšová M. Optic disc drusen - current diagnostic possibilities. Cesk Slov Oftalmol. 2014 Feb;70(1):30-5.
33. Roh S, Noecker RJ, Schuman JS. Evaluation of coexisting optic nerve head drusen and glaucoma with optical coherence tomography. Ophthalmology. 1997;104:1138–1144.
34. Johnson LN, Diehl ML, Hamm CW, Sommerville DN, Petroski GF. Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography. Arch Ophthalmol. 2009 Jan;127(1):45-9.
35. Silverman AL, Tatham AJ, Medeiros FA, MD, PhD, Weinreb RN. Assessment of Optic Nerve Head Drusen Using Enhanced Depth Imaging and Swept Source Optical Coherence Tomography. J Neuroophthalmol. 2014 Jun; 34(2): 198–205.
36. Ubhi P, Shechtman D, Green K.Discern Optic Nerve Head Drusen from True Papilledema. Rewiev of Optometry. Dec, 2015.
37. Pihlbad MS. Optic Nerve Head Drusen. Available from: http://eyewiki.aao.org. Sept, 2015.
38. Kuchenbecker J, Wecke T, Vorwerk CK, Behrens-Baumann W.Quantitative and objective topometrical analysis of drusen of the optic nerve head with the Heidelberg retina tomograph (HRT). Ophthalmologe. 2002 Oct;99(10):768-73.
39. Patel NN, Shulman JP, Chin KJ, Finger PT. Optical coherence tomography/scanning laser ophthalmoscopy imaging of optic nerve head drusen. Ophthalmic Surg Lasers Imaging. 2010. Nov-Dec;41(6):614-21.
40. Tatlipinar S, Kadayifcilar S, Bozkurt B, Gedik S, Karaagaoglu E, Orhan M, Irkeç M. Polarimetric nerve fiber analysis in patients with visible optic nerve head drusen. J Neuroophthalmol. 2001 Dec;21(4):245-9.
41. Vieregge P, Rosengart A, Mehdorn E, Wessel K, Kömpf D. Drusen papilla with vision disorder and pathologic visual evoked potentials. Nervenarzt. 1990 Jun;61(6):364-8.
42. Grippo TM, Ezon I, Kanadani FN, Wangsupadilok B, Tello C, Liebmann JM et all. The Effects of Optic Disc Drusen on the Latency of the Pattern-Reversal Checkerboard and Multifocal Visual Evoked Potentials. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9): 4199–4204.
43. Schargus M, Grippo T, Ritch R, Gramer E. Stage of Visual Field Loss in Relation to the Appearance of the Optic Disc in 144 Eyes of Patients With Drusen of the Optic Disc. Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2483.
44. El-Assal K, Tatham AJ. Rapidly progressing visual loss associated with optic nerve head drusen: Is there a role for lowering intraocular pressure? Journal of Ophthalmic science. 28.Apr 2016.
1. Morris RW, Ellerbrock JM, Hamp AM, Joy JT, Roels P, Davis CN Jr. Advanced visual field loss secondary to optic nerve head drusen: case report and literature review. Optometry. 2009 Feb;80(2):83-100.
2. Schargus M, Gramer E. Optic disc drusen. Ophthalmologe. 2008 Jul;105(7): 693-710.
3. Auw-Haedrich C, Staubach F, Witschel H. Optic disk drusen. Surv Ophthalmol. 2002 Nov-Dec;47(6):515-32.
4. Czajor K, Misiuk-Hojło M. Heidelberg Edge Perimetry in optic nerve drusen – a case report. MEDtube Science Mar, 2014; Vol.II (1)
5. Ubhi P, Shechtman D, Green K. Discern Optic Nerve Head Drusen from True Papilledema. Review of Optometry. Dec. 15, 2015.
6. Friedman AH, Henkind P, Gartner S. Drusen of the optic disc. A histopathological study. Trans Ophthalmol Soc U K. April 1975. 95 (1): 4–9.7. Chang MY, Pineles SL. Optic disk drusen in children. Surv Ophthalmol. 2016 Nov - Dec;61(6):745-758.
8. Gay D, Boyer S.Two differing presentations of optic nerve head drusen. Optometry. 2001. Sep;72(9): 588-96.
9. Davis PL, Jay WM. Optic nerve head drusen. Seminars in Ophthalmology. 2003.Vol. 18(4): 222–24210. Gili P, Flores-Rodríguez P, Yangüela J, Orduña-Azcona J, Martín-Ríos M. Evaluation of optic disc size in patients with optic nerve head drusen using fundus photography. J Optom. 2013. Apr; 6(2): 75–79.
11. Grippo TM, Rogers SW, Tsai JC. Optic Disc Drusen. Glaucoma Today. Jan/Feb 2012.
12. Gaillard F. Optic Disc Drusen. Available from: http:// radiopaedia.org. 2005-2017.
13. Aumiller MS. Optic disc drusen: complications and manage¬ment. Optometry. 2007; 78(1):10–16.
14. Jonas JB, Gusek GC, Guggenmoos Holzmann I, Naumann GO. Pseudopapilledema associated with abnormally small optic discs. Acta Ophthalmol. 1988;66(2):190-193.
15. GrippoTM, Shihadeh WA, Schargus M, Gramer E, Tello C et all. Optic Nerve Head Drusen and Visual Field Loss in Normotensive and Hypertensive Eyes. J Glaucoma 2008;17:100–104.
16. Kamjoo S, Epley KD, Pihlbad MS. Optic Disc Drusen. Available from: http://eyewiki.aao.org. January , 2015.
17. Gossman MV. Pseudopapilledema. Available from: http://emedicine.medscape.com. Oct, 2015.
18. Patel V, Oetting TA. Optic Nerve Drusen: 19-year-old female with blurred vision. EyeRounds.org. August 14, 2007; Available from: http://www.EyeRounds.org/cases.
19. Delyfer MN, Rougier MB, Fourmaux E, Cousin P, Korobelnik JF (April 2004). "Laser photocoagulation for choroidal neovascular membrane associated with optic disc drusen". Acta Ophthalmol Scand. 82 (2): 236–8.
20. Haritoglou C, Prieglinger SG, Grueterich M, Kampik A, Kriegelstein GK. Radial optic neurotomy for the treatment of acute functional impairment associated with optic nerve drusen.Br J Ophthalmol. 2005 Jun; 89(6): 779–780.
21. Pfriem M, Hoerauf H. Unsuccessful surgical excision of optic nerve drusen. Graefes Arch Clin Exp Ophthalmol. 2011. Oct; 249(10): 1583–1585.
22. Kapur R, Pulido JS, Abraham JL, Sharma M, Buerk B, Edward DP. Histologic findings after surgical excision of optic nerve head drusen. Retina. 2008. Jan; 28(1):143-6.
23. Pinxten I, Stalmans P. Radial optic neurotomy as a treatment for anterior ischemic optic neuropathy secondary to optic disc drusen. GMS Ophthalmol Cases; 2014. Jul 15;4.
24. Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GO. Optic nerve head drusen associated with abnormally small optic discs. Int Ophthalmol. 1987 Dec;11(2):79-82.
25. Wilkins J, Pomeranz H. Visual manifestations of visible and buried optic disc drusen. J
Neuroophthalmol. 2004;24(2):125-129.
26. Calvo-González C, Santos-Bueso E, Díaz-Valle D, Reche-Frutos J, Moriche-Carretero M, Benítez-Del-Castillo JM et all. Optic nerve drusen and deep visual fields defects. Arch Soc Esp Oftalmol. 2006 May;81(5):269-73.
27. Obuchowska I, Mariak Z. Visual field defects in the optic disc drusen. Klin Oczna. 2008;110(10-12):357-60.
28. Katz BJ, Pomeranz HD.Visual field defects and retinal nerve fiber layer defects in eyes with buried optic nerve drusen. Am J Ophthalmol. 2006 Feb;141(2):248-253.
29. Spalding JM. Visual-field loss with optic nerve drusen and ocular hypertension: a case report. Optometry. 2002 Jan;73(1):24-32.
30. Sowka J, Kabat A. IOP, Drusen and Occlusion. Rewiev of Optometry. Feb, 2016.31. Pojda-Wilczek D, Herba E, Jedrzejewski W, Pojda SM. Optic disc drusen and glaucoma--case report. Klin Oczna. 2004;106(1-2 Suppl):263-5.
32. Ziak P, Jarabáková K, Koyšová M. Optic disc drusen - current diagnostic possibilities. Cesk Slov Oftalmol. 2014 Feb;70(1):30-5.
33. Roh S, Noecker RJ, Schuman JS. Evaluation of coexisting optic nerve head drusen and glaucoma with optical coherence tomography. Ophthalmology. 1997;104:1138–1144.
34. Johnson LN, Diehl ML, Hamm CW, Sommerville DN, Petroski GF. Differentiating optic disc edema from optic nerve head drusen on optical coherence tomography. Arch Ophthalmol. 2009 Jan;127(1):45-9.
35. Silverman AL, Tatham AJ, Medeiros FA, MD, PhD, Weinreb RN. Assessment of Optic Nerve Head Drusen Using Enhanced Depth Imaging and Swept Source Optical Coherence Tomography. J Neuroophthalmol. 2014 Jun; 34(2): 198–205.
36. Ubhi P, Shechtman D, Green K.Discern Optic Nerve Head Drusen from True Papilledema. Rewiev of Optometry. Dec, 2015.
37. Pihlbad MS. Optic Nerve Head Drusen. Available from: http://eyewiki.aao.org. Sept, 2015.
38. Kuchenbecker J, Wecke T, Vorwerk CK, Behrens-Baumann W.Quantitative and objective topometrical analysis of drusen of the optic nerve head with the Heidelberg retina tomograph (HRT). Ophthalmologe. 2002 Oct;99(10):768-73.
39. Patel NN, Shulman JP, Chin KJ, Finger PT. Optical coherence tomography/scanning laser ophthalmoscopy imaging of optic nerve head drusen. Ophthalmic Surg Lasers Imaging. 2010. Nov-Dec;41(6):614-21.
40. Tatlipinar S, Kadayifcilar S, Bozkurt B, Gedik S, Karaagaoglu E, Orhan M, Irkeç M. Polarimetric nerve fiber analysis in patients with visible optic nerve head drusen. J Neuroophthalmol. 2001 Dec;21(4):245-9.
41. Vieregge P, Rosengart A, Mehdorn E, Wessel K, Kömpf D. Drusen papilla with vision disorder and pathologic visual evoked potentials. Nervenarzt. 1990 Jun;61(6):364-8.
42. Grippo TM, Ezon I, Kanadani FN, Wangsupadilok B, Tello C, Liebmann JM et all. The Effects of Optic Disc Drusen on the Latency of the Pattern-Reversal Checkerboard and Multifocal Visual Evoked Potentials. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9): 4199–4204.
43. Schargus M, Grippo T, Ritch R, Gramer E. Stage of Visual Field Loss in Relation to the Appearance of the Optic Disc in 144 Eyes of Patients With Drusen of the Optic Disc. Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2483.
44. El-Assal K, Tatham AJ. Rapidly progressing visual loss associated with optic nerve head drusen: Is there a role for lowering intraocular pressure? Journal of Ophthalmic science. 28.Apr 2016.