EFFECTS OF NMDA RECEPTOR ANTAGONISTS ON ACUTE POSTOPERATIVE PAIN

  • Maja Z Stojanovic University of Belgrade, Faculty of Medicine, Surgery with Anesthesiology, KBC "Zvezdara", Department of Anesthesiology with Reanimation and Intensive Care
  • Predrag Stevanovic Faculty of medicine, University of Belgrade, Belgrade, Serbia; University Hospital Center Dr Dragiša Mišović, Belgrade, Serbia
  • Sonja Vuckovic Faculty of medicine, University of Belgrade, Belgrade, Serbia; Department of Pharmacology, Clinical Pharmacology and Toxicology,Belgrade, Serbia
  • Katarina Savic Vujovic Faculty of medicine, University of Belgrade, Belgrade, Serbia; Department of Pharmacology, Clinical Pharmacology and Toxicology,Belgrade, Serbia
DOI: https://doi.org/10.5937/medi0-58810
Keywords: NMDA-antagonists, ketamine, magnesium-sulfate, acute pain

Abstract


Introduction/Aim of the paper: Pain represents a multifactorial process with detrimental effects on the entire organism. This randomized, open-label pilot study investigated the effect of preemptive administration of ketamine and magnesium-sulfate on the intensity of postoperative
pain after laparoscopic colon tumor resection.

Methods: Sixty patients were randomized into the ketamine-magnesium (KM) and the control (C) groups. After the introduction to anesthesia, patients in the KM group received an i.v. bolus dose of 0.5 mg/kg ketamine, followed by a continuous infusion of 0.6 mg/kg/h lasting  until the end of surgery. After a bolus dose of ketamine, they received magnesium-sulfate 20 mg/kg in an intravenous infusion (5-10 minutes). Group C received only 0.9% NaCl infusion. After the
patients were awakened (0h), the pain intensity was compared (0- 46h) between the two groups.

Results: The Mann-Whitney test implied significantly (p<0.05) lower visual analog scale (VAS) scores, in KM group at 0, 1, 2, 10, 22 and 30 hours after the surgery, and no statistical significance (p>0.05) for VAS scores after 6, 14, 18, 38 and 46 hours, compared to C group. Ketamine and magnesium-sulfate significantly (p<0.05) reduced the postoperative consumption of analgesics, increased the sedation level at 0h postoperatively, and increased the overall patient satisfaction with the treatment.

Conclusion: Preemptive administration of ketamine and magnesium-sulfate combination has beneficial effect on postoperative pain after laparoscopic colon tumor resection.

 

Author Biography

Maja Z Stojanovic, University of Belgrade, Faculty of Medicine, Surgery with Anesthesiology, KBC "Zvezdara", Department of Anesthesiology with Reanimation and Intensive Care

klinički asistent, specijalista anesteziologije i reanimatologije, Služba za anesteziju, reanimaciju i intenzivno lečenje, KBC "Zvezdara", Beograd

Published
2025/08/25
Issue
Online First
Section
Članci