MULTIPLI BAZOCELULARNI KARCINOMI NAKON PRIMENE RADIOTERAPIJE U LEČENJU TINEA CAPITIS U DETINJSTVU: PRIKAZ SLUČAJA I PREGLED LITERATURE

Jelena Cakić; Branislav Lekić; Iva Maširević Mudrić; Marija Tomanović; Svetlana Popadić

doi:10.5937/medi57-45915

Jelena Cakić Clinic of Dermatovenereology, University Clinical Centre of Serbia, Belgrade, Serbia https://orcid.org/0009-0000-5359-674X
Branislav Lekić Clinic of Dermatovenereology, University Clinical Center of Serbia, Belgrade, Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia https://orcid.org/0000-0003-3976-0173
Iva Maširević Mudrić Clinic of Dermatovenereology, University Clinical Center of Serbia, Belgrade, Serbia https://orcid.org/0009-0001-9666-9205
Marija Tomanović Clinic of Dermatovenereology, University Clinical Center of Serbia, Belgrade, Serbia https://orcid.org/0000-0002-3068-2319
Svetlana Popadić Clinic of Dermatovenereology, University Clinical Center of Serbia, Belgrade, Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia https://orcid.org/0000-0002-5491-8509

DOI: https://doi.org/10.5937/medi57-45915

Keywords: basal cell carcinoma, ionizing radiation, radiotherapy, tinea capitis, treatment

Abstract

Introduction: Basal cell carcinoma (BCC) is the most frequent skin cancer with a rising incidence worldwide. Predilection sites are head and neck in 80-85% of cases. The leading risk factors are sun exposure and ionizing radiation. In the middle of the 20th century, radiation-induced epilation was used as an efficient treatment method for tinea capitis.

Patient review: We report a case of an 80-year-old man with a 16-year history of the successive occurrence of multiple BCCs on the scalp, face, and neck. He also had the history of tinea capitis treated by radiotherapy during childhood. At presentation during clinical and dermoscopic examination approximately twenty-five BCCs were observed, predominantly on scalp. The most common BCC lesion was the nodular subtype, followed by the pigmented and superficial subtypes. Histopathological examination conﬁrmed the diagnosis of BCC in multiple lesions and one squamous cell carcinoma (SCC). In personal history most important comorbidity was hairy cell leukemia. The therapeutic approach was surgery and 5-fluorouracil 5% cream.

Conclusion: Radiation-induced epilation was used as an efficient method for treatment of tinea capitis. One of the side effects was appearance of BCC in radiation exposed areas. Surgical excision is the gold standard for BCC treatment. Also, 5-fluorouracil 5% cream may be a good option for patients with multiple BCCs. We present satisfactory results after combined treatment in our patient.

MULTIPLE BASAL CELL CARCINOMAS FOLLOWING X-RAY TREATMENT FOR TINEA CAPITIS IN CHILDHOOD: A CASE REPORT AND A LITERATURE REVIEW

Abstract