AKUTNA RADIJACIONA TOKSIČNOST KOD PACIJENATA SA GLIOBLASTOMOM KOJI SU LEČENI HIPOFRAKCIONISANOM RADIOTERAPIJOM:

Aleksandar Stepanović; Tatjana Arsenijević; Aleksandar Tomašević; Ivan Bogdanović; Katarina Kopčalić; Bojana Poparić-Banđur; Marina Nikitović

doi:10.5937/medi57-52237

Aleksandar Stepanović Faculty of Medicine, University of Belgrade https://orcid.org/0000-0001-9556-974X
Tatjana Arsenijević Faculty of Medicine, University of Belgrade https://orcid.org/0000-0002-7531-7948
Aleksandar Tomašević Faculty of Medicine, University of Belgrade https://orcid.org/0000-0002-2715-3504
Ivan Bogdanović Faculty of Medicine, University of Belgrade https://orcid.org/0000-0003-0055-5201
Katarina Kopčalić Institute for Oncology and Radiology of Serbia https://orcid.org/0000-0001-5599-6501
Bojana Poparić-Banđur Institute for Oncology and Radiology of Serbia https://orcid.org/0009-0007-4029-1710
Marina Nikitović Faculty of Medicine, University of Belgrade https://orcid.org/0000-0001-7272-9587

DOI: https://doi.org/10.5937/medi57-52237

Keywords: Glioblastoma, Hypofractionated radiotherapy, Acute toxicity

Abstract

Introduction. Hypofractionated radiotherapy is the preferred regimen for older patients with glioblastoma and those with poor prognostic factors. Acute radiation toxicity remains a concern in these cases.

Aim. We conducted a retrospective analysis aiming to show the acute toxicity profile in patients with glioblastoma treated with hypofractionated radiotherapy, with or without temozolomide.

Material and Methods. This study included 25 patients with diagnosed glioblastoma who underwent a hypofractionated regimen of radiotherapy, with a dose of 40 Gy in 15 fractions or 34 Gy in 10 fractions. Acute radiation toxicity was observed during the treatment and graded according to Common Terminology Criteria for Adverse Events, version 5.0.

Results. Radiation toxicity was experienced in 60% of the patients. The majority of the patients with toxicity (80%) had toxicity grade 1. One patient (6.7%) exhibited grade 3 radiation toxicity. No patients had grade 4 radiation toxicity. A statistically significantly higher number of patients who experienced radiotoxicity were predominantly distributed in the group with tumors located in more than 1 lobe, multifocal or multicentric tumor compared to patients who had a tumor in one lobe (p < 0.01).

Conclusions. A hypofractionated regimen of radiotherapy represents a favorable option for the treatment of older patients with glioblastoma or those with poor prognosis, with an acceptable acute radiation toxicity profile.

Author Biographies

Aleksandar Stepanović, Faculty of Medicine, University of Belgrade

Asst. Prof. Aleksandar Stepanović^,MD, PhD

Faculty of Medicine, University of Belgrade, Dr Subotića 8 Street, Belgrade, Serbia

Chief of the Department for Radiotherapy of CNS Tumors, Thoracic Tumors and Hematologic Malignancies

Clinic for Radiation Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14 Street, Belgrade, Serbia

Tatjana Arsenijević, Faculty of Medicine, University of Belgrade

Associate Professor Tatjana Arsenijević, MD, PhD

Faculty of Medicine, University of Belgrade, Dr Subotića 8 Street, Belgrade, Serbia

Head of the Department for Radiotherapy of Solid Tumors, Institute for Oncology and Radiology of Serbia, Pasterova 14 Street, Belgrade, Serbia

Aleksandar Tomašević, Faculty of Medicine, University of Belgrade

Asst. Prof. Aleksandar Tomašević^,MD, PhD

Faculty of Medicine, University of Belgrade, Dr Subotića 8 Street, Belgrade, Serbia

Director of the Clinic of Radiation Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14 Street, Belgrade, Serbia

Ivan Bogdanović, Faculty of Medicine, University of Belgrade

Asst. Prof. Ivan Bogdanović, MD

Faculty of Medicine, University of Belgrade, Dr Subotića 8 Street, Belgrade, Serbia

Clinic for Neurosurgery, University Clinical Center of Serbia, Belgrade, Serbia

Katarina Kopčalić, Institute for Oncology and Radiology of Serbia

Katarina Kopčalić,^,MD

Clinic for Radiation Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14 Street, Belgrade, Serbia

Bojana Poparić-Banđur, Institute for Oncology and Radiology of Serbia

Clinic for Radiation Oncology, Institute for Oncology and Radiology of Serbia, Pasterova 14 Street, Belgrade, Serbia

Marina Nikitović, Faculty of Medicine, University of Belgrade

Full Professor of Oncology and Radiology
Chief of Undergraduate Studies in Oncology
Chief of Postgraduate Studies in Oncology
Faculty of Medicine, University of Belgrade, Serbia
Deputy Director for Research and Education
Clinical Director, Department for Radiotherapy of Solid Tumors
Consultant for Pediatric Radiation Oncology
Institute for Oncology and Radiology of Serbia

ACUTE RADIATION TOXICITY IN PATIENTS WITH GLIOBLASTOMA TREATED WITH HYPOFRACTIONATED RADIOTHERAPY

Acute Toxicity of Hypofractionated Radiotherapy in Glioblastoma

Abstract

Author Biographies