OKSIDATIVNI STRESS I OPSTETRIČKE KOMPLIKACIJE KOD TRUDNICA SA NASLEDNOM TROMBOFILIJOM, SA I BEZ TERAPIJE HEPARINOM NISKE MOLEKULSKE TEŽINE

Dragana Maglic; Vesna Mandic Markovic; Jelena Bogdanovic Pristov; Rastko Maglic; Olivera Dzatic Smiljkovic; Radomir Anicic; Milica Mandic; Jelena Mitrovic; Sabrina Skrijelj

doi:10.5937/medi57-53290

Dragana Maglic Medicinski fakultet Univerziteta u Beogradu https://orcid.org/0000-0003-4788-4707
Vesna Mandic Markovic Faculty of Medicine, University of Belgrade, Belgrade, Serbia https://orcid.org/0000-0002-0005-8443
Jelena Bogdanovic Pristov Life Sciences Department, Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbi https://orcid.org/0000-0003-4322-7208
Rastko Maglic Faculty of Medicine, University of Belgrade, Belgrade, Serbia https://orcid.org/0000-0002-6125-0973
Olivera Dzatic Smiljkovic Faculty of Medicine, University of Belgrade, Belgrade, Serbia https://orcid.org/0009-0003-4271-9785
Radomir Anicic Faculty of Medicine, University of Belgrade, Belgrade, Serbia https://orcid.org/0000-0001-5418-7411
Milica Mandic Department for High-Risk Pregnancies, University Clinic for Gynecology and Obstetrics Narodni front,” Belgrade, Serbia
Jelena Mitrovic Department for High-Risk Pregnancies, University Clinic for Gynecology and Obstetrics Narodni front,” Belgrade, Serbia
Sabrina Skrijelj Department for High-Risk Pregnancies, University Clinic for Gynecology and Obstetrics Narodni front,” Belgrade, Serbia

DOI: https://doi.org/10.5937/medi57-53290

Keywords: Thrombophilia, Obstetric complication, Oxidative stress

Abstract

ABSTRACT:

Introduction: Inherited thrombophilia (IT) presents genetic conditions associated with risk of deep vascular thrombosis (DVT) and obstetric complications (OC) such as preeclampsia (PE), fetal growth restriction (FGR), stillbirth and placental abruption (PA).

The aim of our study was to evaluate frequency of OC and oxidative stress (OS) in women with IT during pregnancies with and without low molecular weight therapy (LMWH), comparing with women with healthy pregnancies.

Materials and methods: We evaluated 60 pregnant women with IT diagnosed before ongoing pregnancy based on previous DVT or OC (study group) and 60 healthy pregnant women (control group). In all subject’s blood samples before delivery and placental tissue were collected and activity of CAT, GPX, GH, SH, GR, CuZnSOD, and MnSOD were determined.

Results After the introduction of LMWH therapy, the total number of OC decreased significantly in women with IT. Analyzing the association between OC and different kinds of IT, we found significant association only between Factor V Leiden mutation and Protein C deficiency with GH/PE. Levels of SH is higher in IT; CAT, GPH and GR are three times more active in patients with IT with LMWH therapy compared to control group.

Conclusion Values of OS parameters in pregnant women with IT during delivery may confirm increased OS in those patients indicating that introduction of antioxidant therapy may be advisable.

Author Biography

Jelena Bogdanovic Pristov, Life Sciences Department, Institute for Multidisciplinary Research, University of Belgrade, Belgrade, Serbi

Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije (ugovor br 451-03-66/2024-03/20053)

OXIDATIVE STRESS AND OBSTETRIC COMPLICATIONS IN PREGNANT WOMEN WITH INHERITED THROMBOPHILIA WITH AND WITHOUT LOW MOLECULAR WEIGHT HEPARIN THERAPY

Abstract

Author Biography