Stem Cell-Based Therapies Combined With Nano-Biomaterials for Nerve Regeneration and Repair

Vishnu Mittal; Anjali  Sharma; Rajat  Goyal; Kashish Wilson; Tanuj Hooda; Shivani  Chopra; Hitesh Chopra

doi:10.5937/scriptamed57-61182

Vishnu Mittal Adesh College of Pharmacy
Anjali Sharma Guru Gobind Singh College of Pharmacy
Rajat Goyal MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-133207, Ambala, Haryana, India
Kashish Wilson MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-133207, Ambala, Haryana, India
Tanuj Hooda MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-133207, Ambala, Haryana, India
Shivani Chopra Saveetha University
Hitesh Chopra Chitkara University

DOI: https://doi.org/10.5937/scriptamed57-61182

Keywords: Nerve regeneration, Stem cells, Nanostructures, Nanotechnology, Biomedical engineering, scaffolds, Growth, axonal, Neuroprotection

Abstract

Nerve injuries, often resulting from trauma or degenerative diseases, pose significant challenges due to limited regenerative capacity of nervous system. Conventional treatments, including surgical nerve grafts, exhibit limitations such as donor site morbidity and limited functional recovery. Emerging regenerative strategies combining stem cell-based therapies with nano-biomaterials offer promising solutions for enhancing nerve regeneration and functional restoration. A comprehensive review of recent advancements in stem cell sources and induced pluripotent stem cells (iPSCs) was discussed. Also design, properties and applications of nano-biomaterials such as nanoparticles, nanofibers and hydrogels in nerve repair were analysed. Preclinical and clinical studies demonstrating effectiveness of these combined strategies were evaluated. The integration of stem cells with nano-biomaterials has demonstrated improved nerve regeneration outcomes, including enhanced neuronal differentiation, reduced inflammation and accelerated axonal growth. Studies indicate that biomaterial scaffolds provide structural support and biochemical cues, facilitating stem cell survival and integration into damaged neural tissues. Stem cell-based therapies combined with nano-biomaterials represent a promising approach for nerve regeneration. This combinatorial strategy offers enhanced neuroprotection, functional recovery and long-term stability in neural repair. Future research should focus on optimising scaffold properties, improving cell survival rates and translating preclinical findings into clinical applications.

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