Pristupi multiomicima u istrazivanju kardiovaskularne bolesti
Sažetak
Cardiovascular diseases remain number 1 killer world-wide. New technologies, particularly the novel approaches at genetics, transcriptomics, proteomics and metabolomics levels have provided new insights into the disease aetiology, pathophysiology and diagnosis, as well as therapeutics from molecular level. These omics by integrating the nuclear, cellular components, proteins, enzymes generate large data sets gather the information with support of organised and systematic computational methods. The integrated analyses may give deeper view on the development, treatment and prevention of the disease. In recent
years, multi-omics technologies have been used in research on cardiovascular diseases including coronary artery disease, heart valve disease and congenital heart disease. These studies help in understanding the aetiology and pathophysiology of the disease and facilitate the precision diagnosis, therapy and prognosis.
Reference
World Health Organization [Internet]. [Cited: 1-Jun-2022]. Available at: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death.
Guo ZP, Hou HT, Jing R, Song ZG, Liu XC, He GW. Plasma protein profiling in patients undergoing coronary artery bypass grafting surgery and clinical significance. Oncotarget 2017 Mar 18;8(36):60528-38.
Li XY, Hou HT, Chen HX, Liu XC, Wang J, Yang Q, et al. Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery. J Thorac Cardiovasc Surg 2021 Sep;162(3):851-63.e3.
Gao G, Xuan C, Yang Q, Liu XC, Liu ZG, He GW. Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance. PLoS One 2013 Aug 27;8(8):e72111. doi: 10.1371/journal.pone.0072111.
Jiang YY, Hou HT, Yang Q, Liu XC, He GW. Chloride channels are involved in the development of atrial fibrillation - a transcriptomic and proteomic study. Sci Rep 2017 Aug 31;7(1):10215. doi: 10.1038/s41598-017-10590-w.
Chen HX, Li MY, Jiang YY, Hou HT, Wang J, Liu XC, et al. Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue. Signal Transduct Target Ther 2020 Jan 17;5(1):4. doi: 10.1038/s41392-019-0093-2.
Li MY, Chen HX, Hou HT, Wang J, Liu XC, Yang Q, et al. Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study. Ann Transl Med 2021 Mar;9(5):393. doi: 10.21037/atm-20-3767.
Murray CJ, Richards MA, Newton JN, Fenton KA, Anderson HR, Atkinson C, et al. UK health performance: findings of the Global Burden of Disease Study 2010. Lancet 2013 Mar 23;381(9871):997-1020.
Hou HT, Chen HX, Wang XL, Yuan C, Yang Q, Liu ZG, et al. Genetic characterisation of 22q11.2 variations and prevalence in patients with congenital heart disease. Arch Dis Child 2020 Apr;105(4):367-74.
Chen HX, Yang ZY, Hou HT, Wang J, Wang XL, Yang Q, et al. Novel mutations of TCTN3/LTBP2 with cellular function changes in congenital heart disease associated with polydactyly. J Cell Mol Med 2020 Dec;24(23):13751-62.
Xuan C, Jia KG, Wang BB, Bai XY, Gao G, Yang Q, et al. Identification of two novel mutations of the HOMEZ gene in Chinese patients with isolated ventricular septal defect. Genet Test Mol Biomarkers 2013 May;17(5):390-4.
Xuan C, Wang BB, Gao G, Bai XY, Yang Q, Liu XC, et al. A novel variation of PLAGL1 in Chinese patients with isolated ventricular septal defect. Genet Test Mol Biomarkers 2012 Aug;16(8):984-7.
Zheng SQ, Chen HX, Liu XC, Yang Q, He GW. Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects. Am J Physiol Cell Physiol 2021 Sep 1;321(3):C443-C52.
Zheng SQ, Chen HX, Liu XC, Yang Q, He GW. Genetic analysis of the CITED2 gene promoter in isolated and sporadic congenital ventricular septal defects. J Cell Mol Med 2021 Feb;25(4):2254-61.
Xuan C, Gao G, Yang Q, Wang XL, Liu ZG, Liu XC, et al. Proteomic study reveals plasma protein changes in congenital heart diseases. Ann Thorac Surg 2014 Apr;97(4):1414-9.
Zhang X, Wang K, Yang Q, Wang J, Xuan C, Liu XC, et al. Acute phase proteins altered in the plasma of patients with congenital ventricular septal defect. Proteomics Clin Appl 2015 Dec;9(11-12):1087-96.
He GW, Hou HT, Xuan C, Wang J, Liu LX, Zhang JF, et al. Corrective surgery alters plasma protein profiling in congenital heart diseases and clinical perspectives. Am J Transl Res 2020 Apr 15;12(4):1319-37.
Hou HT, Xi-Zhang, Wang J, Liu LX, Zhang JF, Yang Q, et al. Altered plasma proteins released from platelets and endothelial cells are associated with human patent ductus arteriosus. J Cell Physiol 2019 May;234(5):6842-53.
Zhang X, Hou HT, Wang J, Liu XC, Yang Q, He GW. Plasma proteomic study in pulmonary arterial hypertension associated with congenital heart diseases. Sci Rep 2016 Nov 25;6:36541. doi: 10.1038/srep36541.
Yuan C, Chen HX, Hou HT, Wang J, Yang Q, He GW. Protein biomarkers and risk scores in pulmonary arterial hypertension associated with ventricular septal defect: integration of multi-omics and validation. Am J Physiol Lung Cell Mol Physiol 2020 Nov 1;319(5):L810-L22.
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