Blockchain Technology in Pharmaceutical Industry: A Review of Recent Research Articles on PubMed

An Evolving Paradigm

Ključne reči: Blockchain Technology, Pharmaceutical Industry, Smart Contracts, Decentralised Applications (dApps), Drug Supply Chain

Sažetak


Blockchain technology has emerged as a formidable force ready to transform the pharmaceutical business. This study investigated the integration of smart contracts and decentralised apps as potential future possibilities, emphasising their ability to automate crucial operations and strengthen pharmaceutical product integrity, based on the recently published articles in PubMed between 2015 to 2023 with “pharmacology” and “blockchain” as search keywords. Recent study backed up the idea that blockchain can improve openness, security and efficiency in the industry. According to research, it has the ability to speed up regulatory approvals while also considerably reducing the risk of counterfeit medications penetrating the supply chain. Furthermore, the ability of blockchain to disrupt existing intermediaries and enable disintermediation may result in a more streamlined and efficient industry. While there are implementation obstacles, the benefits of this technology in medicines are significant. Embracing blockchain promises a future of increased security, transparency and patient-centricity, ultimately changing healthcare. This article explored blockchain application in the pharmaceutical sector with innovations like Medledger and chaincodes, addressing drug tracing and supply chain security. It presents a structure for a private network using Hyperledger Fabric, showcasing blockchain's potential to enhance transparency, security and efficiency beyond traditional areas.

Reference

Kuo TT, Kim HE, Ohno-Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. J Am Med Inform Assoc. 2017 Nov 1;24(6):1211-20. doi: 10.1093/jamia/ocx068.

Hasselgren A, Wan PK, Horn M, Kralevska K, Gligoroski D, Faxvaag A. GDPR compliance for blockchain applications in healthcare. arXiv preprint arXiv:2009.12913. 2020 Sep 27. doi:10.48550/arXiv.2009.12913.

Alruwaili FF. Artificial intelligence and multi agent based distributed ledger system for better privacy and security of electronic healthcare records. PeerJ Comp Sci. 2020 Nov 30;6:e323. doi: 10.7717/peerj-cs.323.

Naughton BD. Medicine authentication technology: a quantitative study of incorrect quarantine, average response times and offline issues in a hospital setting. BMJ Open. 2019 Feb 1;9(2):e026619. doi: 10.1136/bmjopen-2018-026619

Kiester L, Turp C. Artificial intelligence behind the scenes: PubMed's Best Match algorithm. J Med Libr Assoc. 2022 Jan 1;110(1):15-22. doi: 10.5195/jmla.2022.1236.

Wu L, Ji C, Lu H, Hong X, Liu S, Zhang Y, et al. Standardization of medical service indicators: A useful technique for hospital administration. Plos One. 2018 Nov 28;13(11):e0207214. doi: 10.1371/journal.pone.0207214.

Moore W, Frye S. Review of HIPAA, part 1: history, protected health information, and privacy and security rules. J Nucl Med Technol. 2019 Dec;47(4):269-72. doi: 10.2967/jnmt.119.227819.

Steinwandter V, Herwig C. Provable data integrity in the pharmaceutical industry based on version control systems and the blockchain. PDA J Pharm Sci Technol. 2019;73(4):373-90. doi: 10.5731/pdajpst.2018.009407.

Jia Q. Research on medical system based on blockchain technology. Medicine (Baltimore). 2021 Apr 23;100(16):e25625. doi: 10.1097/MD.0000000000025625.

Wang Y, Zhong M, Cheng T. Research on PBFT consensus algorithm for grouping based on feature trust. Sci Rep. 2022 Jul 22;12(1):12515. doi: 10.1038/s41598-022-15282-8.

Peng S, Hu X, Zhang J, Xie X, Long C, Tian Z, et al. An efficient double-layer blockchain method for vaccine production supervision. IEEE Trans Nanobioscience. 2020 Jul;19(3):579-87. doi: 10.1109/TNB.2020.2999637.

Lee HA, Kung HH, Udayasankaran JG, Kijsanayotin B, B Marcelo A, Chao LR, et al. An architecture and management platform for blockchain-based personal health record exchange: development and usability study. J Med Internet Res. 2020 Jun 9;22(6):e16748. doi: 10.2196/16748.

Tseng JH, Liao YC, Chong B, Liao SW. Governance on the drug supply chain via Gcoin blockchain. Int J Environ Res Public Health. 2018 May 23;15(6):1055. doi: 10.3390/ijerph15061055.

Mackey TK, Kuo TT, Gummadi B, Clauson KA, Church G, Grishin D, et al. 'Fit-for-purpose?' - challenges and opportunities for applications of blockchain technology in the future of healthcare. BMC Med. 2019 Mar 27;17(1):68. doi: 10.1186/s12916-019-1296-7.

Mackey T, Bekki H, Matsuzaki T, Mizushima H. Examining the potential of blockchain technology to meet the needs of 21st-century Japanese health care: viewpoint on use cases and policy. J Med Internet Res. 2020 Jan 9;22(1):e13649. doi:10.2196/13649.

Uddin M. Blockchain Medledger: Hyperledger fabric enabled drug traceability system for counterfeit drugs in pharmaceutical industry. Int J Pharm. 2021 Mar 15;597:120235. doi:10.1016/j.ijpharm.2021.120235.

Xiao Y, Xu B, Jiang W, Wu Y. The HealthChain blockchain for electronic health records: development study. J Med Internet Res. 2021 Jan 22;23(1):e13556. doi: 10.2196/13556.

Nair R, Zafrullah SN, Vinayasree P, Singh P, Zahra MM, Sharma T, et al. Blockchain-based decentralized cloud solutions for data transfer. Comput Intell Neurosci. 2022 May 30;2022:8209854. doi: 10.1155/2022/8209854.

Gopalakrishna P, Suresh SA blockchain framework for clinical trial data management. J Med Sys. 2019;43(9):1-10. doi: 10.1007/s10916-019-1426-4.

Mak BC, Addeman BT, Chen J, Papp KA, Gooderham MJ, Guenther LC, et al. Leveraging blockchain technology for informed consent process and patient engagement in a clinical trial pilot. Blockchain Healthc Today. 2021;4. doi: 10.30953/bhty.v4.182.

Gürsoy G, Brannon CM, Ni E, Wagner S, Khanna A, Gerstein M. Storing and analyzing a genome on a blockchain. Genome Biol. 2022 Jun 29;23(1):134. doi: 10.30953/bhty.v4.182.

Russo-Spena T, Mele C, Cavacece Y, Ebraico S, Dantas C, Roseiro P, et al. Enabling value co-creation in healthcare through blockchain technology. Int J Environ Res Public Health. 2022 Dec 21;20(1):67. doi:10.3390/ijerph20010067.

Dubovitskaya A, Novotny P, Xu Z, Wang F. Applications of blockchain technology for data-sharing in oncology: results from a systematic literature review. Oncology. 2020;98(6):403-11. doi:10.1159/000504325.

MediLedger-Blockchain in Life Sciences 2017 [Internet]. [Cited: 17-May-2022]. Available from: https://www.chronicled.com/.

Objavljeno
2024/06/28
Rubrika
Aktuelna tema