Nutrigenomics: A Budding Cross-Over

  • Navidha Aggarwal MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana-133207, Ambala, Haryana, India
  • Rohit Malik Faculty of Pharmaceutical Sciences, The ICFAI University, Jaipur - 302031, Rajasthan, India
  • Arun Mittal Department of Pharmacognosy and Phytochemistry, Hindu College of Pharmacy, Sonipat, Haryana, India
  • Shiva Tushir Department of Pharmacy, Panipat Institute of Engineering and Technology, Samalkha, Haryana, India
  • Shivani Chopra Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical a
  • Hitesh Chopra Chitkara College of Pharmacy, Chitkara University, Punjab, India
DOI: https://doi.org/10.5937/scriptamed56-54812

Sažetak


Nutrigenomics is a rapidly developing subject that combines genomics and nutrition to reveal the complex interactions between our genetic composition and the foods we consume. This review paper provides a thorough overview of nutrigenomics, exploring its underlying theories, methods and significant implications for customised nutrition and healthcare. The goal of nutrigenomics is to understand the molecular processes underlying the diverse ways in which people respond to different diets by examining the dynamic interplay between an individual’s genetic profile and the nutrients they ingest. To provide a sophisticated knowledge of the genetic elements that contribute to the variation in human reactions to dietary components, this inquiry starts with an explanation of the fundamental concepts of genetics and genomics. The review paper continues to describe the approaches used in nutrigenomic research, with a focus on using state-of-the-art technology like bioinformatics and high-throughput sequencing. These instruments enable scientists to unravel the intricate connections between genetic variants and dietary components, leading to a more sophisticated understanding of how our genes regulate our reactions to particular foods. Nutrigenomics key component is its ability to open the door to customised nutrition. Practitioners are able to customise dietary advice for each patient based on their distinct genetic predispositions by analysing their genetic code. The one-size-fits-all strategy is superseded by this method, recognising the innate genetic variability affecting how our bodies metabolise and react to various nutrients. This review article covers current research findings, shedding light on the potential of nutrigenomics to revolutionise disease management through precision nutrition.

Reference

Hyman M. Ultrametabolism. NY, USA: Simon and Schuster; 2008 Mar 4. doi: 10.31826/9781463213336-022.

Chen Y, Michalak M, Agellon LB. Focus: Nutrition and food science: Importance of nutrients and nutrient metabolism on human health. Yale J Biol Med. 2018 Jun;91(2):95. doi: 10.31031/ntnf.2018.01.000513.

Ordovas JM, Ferguson LR, Tai ES, Mathers JC. Personalised nutrition and health. BMJ. 2018 Jun 13;361. doi: 10.1136/bmj.k2173.

Carlberg C, Ulven SM, Molnár F. Nutrigenomics: how science works. Berlin/Heidelberg, Germany: Springer; 2020 Jan 1. doi: 10.1007/978-3-030-36948-4.

Sturm RA, Duffy DL. Human pigmentation genes under environmental selection. Genome Biol 2012 Sep;13:1-5. doi: 10.1093/ww/9780199540884.013.u37466.

Gerbault P, Liebert A, Itan Y, Powell A, Currat M, Burger J, et al. Evolution of lactase persistence: an example of human niche construction. Philos Trans R Soc Lond B Biol Sci. 2011 Mar 27;366(1566):863-77. doi: 10.1098/rstb.2010.0268.

Wells JC. Body composition and susceptibility to type 2 diabetes: an evolutionary perspective. Eur J Clin Nutrit. 2017 Jul;71(7):881-9. doi: 10.1038/ejcn.2017.31.

Carlberg C. Nutrigenomics in the context of evolution. Redox Biology. 2023 Jun 1;62:102656. doi: 10.1016/j.redox.2023.102656.

Livingstone KM, Ramos-Lopez O, Perusse L, Kato H, Ordovas JM, Martínez JA. Reprint of: Precision nutrition: A review of current approaches and future endeavors. Trends Food Sci Technol. 2022 Dec 1;130:51-62. doi: 10.1016/j.tifs.2022.10.010

Pavlidis C, Lanara Z, Balasopoulou A, Nebel JC, Katsila T, Patrinos GP. Meta-analysis of genes in commercially available nutrigenomic tests denotes lack of association with dietary intake and nutrient-related pathologies. Omics: J Integrat Biol. 2015 Sep 1;19(9):512-20. doi: 10.1016/j.tifs.2017.02.010.

Pavlidis C, Nebel JC, Katsila T, Patrinos GP. Nutrigenomics 2.0: The need for ongoing and independent evaluation and synthesis of commercial nutrigenomics tests' scientific knowledge base for responsible innovation. Omics: J Integrat Biol.2016 Feb 1;20(2):65-8. doi: 10.1080/10408398.2020.1852173.

Sikalidis AK. From food for survival to food for personalized optimal health: A historical perspective of how food and nutrition gave rise to nutrigenomics. J Am Coll Nutrit. 2019 Jan 2;38(1):84-95. doi: 10.1016/j.tifs.2022.09.001.

Neeha VS, Kinth P. Nutrigenomics research: a review. J Food Sci Technol. 2013 Jun;50:415-28. doi: 10.1007/s13197-012-0775-z,

Ronteltap A, van Trijp H, Berezowska A, Goossens J. Nutrigenomics-based personalised nutritional advice: in search of a business model? Genes Nutrit. 2013 Mar;8:153-63. doi: 10.1016/j.tifs.2024.104340.

Peironcely JE, Reijmers T, Coulier L, Bender A, Hankemeier T. Understanding and classifying metabolite space and metabolite-likeness. PloS one. 2011 Dec 14;6(12):e28966. doi: 10.1016/j.tifs.2022.07.007.

Edwards LM. Metabolic systems biology: a brief primer. J Physiol. 2017 May 1;595(9):2849-55. doi: 10.1016/j.tifs.2021.12.024.

Brookheart RT, Duncan JG. Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster. Reproduction (Cambridge, England). 2016 Sep;152(3):R79. doi: 10.1016/j.tifs.2022.09.002.

Juárez-Maldonado A, Ortega-Ortíz H, Morales-Díaz AB, González-Morales S, Morelos-Moreno Á, Cabrera-De la Fuente M, et al. Nanoparticles and nanomaterials as plant biostimulants. Int J Mol Sci. 2019 Jan 4;20(1):162. doi: 10.1016/j.tifs.2022.09.007.

Corella D, Ordovas JM. Nutrigenomics in cardiovascular medicine. Circulation: Cardiovascular Genetics. 2009 Dec;2(6):637-51. doi: 10.12944/crnfsj.10.3.1.

Barnett MP, Ferguson LR. Nutrigenomics: Integrating genomic approaches into nutrition research. InMolecular diagnostics 2017 Jan 1 (pp. 305-326). Cambridge, MA: Academic Press. doi: 10.1007/978-3-030-73692-7_3.

Stielow M, Witczyńska A, Kubryń N, Fijałkowski Ł, Nowaczyk J, Nowaczyk A. The Bioavailability of Drugs—The Current State of Knowledge. Molecules. 2023 Dec 11;28(24):8038. doi: 10.1016/j.tifs.2024.104727

Subramanian P. Mucoadhesive delivery system: a smart way to improve bioavailability of nutraceuticals. Foods. 2021 Jun 11;10(6):1362. doi: 10.1016/j.tifs.2021.12.011.

Zhao J, Li Z, Gao Q, Zhao H, Chen S, Huang L, Wang W, Wang T. A review of statistical methods for dietary pattern analysis. Nutrit J. 2021 Dec;20:1-8. doi: 10.1016/j.tifs.2022.03.014.

Vega L. Fundamentals of genetics. Scientific e-Resources; 2019 Sep 13. doi: 10.1016/j.tifs.2019.01.017.

Kussmann M, Fay LB. Nutrigenomics and personalized nutrition: science and concept. Per Med. 2008 Sep;5(5):447-55. doi: 10.2217/17410541.5.5.447.

Kaput J, Rodriguez RL. Nutritional genomics: the next frontier in the postgenomic era. Physiological Genomics. 2004 Jan 15;16(2):166-77. doi: 10.1016/s0924-2244(00)88912-8.

Gibney G. Nutrigenomics in human nutrition–an overview. South African J Clin Nutrit. 2005 Sep 1;18(2):115-8. doi: 10.1016/s0924-2244(99)00059-x.

Segal E, Friedman N, Koller D, Regev A. A module map showing conditional activity of expression modules in cancer. Nature Genetics. 2004 Oct 1;36(10):1090-8. doi: 10.1016/j.tifs.2022.08.019.

Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nature Rev Genetics. 2005 Apr 1;6(4):271-86. doi: 10.1016/j.tifs.2017.09.002.

Bahinipati J, Sarangi R, Mishra S, Mahapatra S. Nutrigenetics and nutrigenomics: A brief review with future prospects. Biomedicine. 2021 Dec 31;41(4):714-9. doi: 10.1002/fsn3.1892.

Gush L, Shah S, Gilani F. Macronutrients and micronutrients. InA prescription for healthy living 2021 Jan 1 (pp. 255-273). Cambridge, MA: Academic Press. doi: 10.1016/j.tifs.2022.03.017.

Fagbohun OF, Gillies CR, Murphy KP, Rupasinghe HV. Role of antioxidant vitamins and other micronutrients on regulations of specific genes and signaling pathways in the prevention and treatment of cancer. Int J Mol Sci. 2023 Mar 23;24(7):6092. doi: 10.1016/j.tifs.2022.01.012.

Lal MK, Sharma E, Tiwari RK, Devi R, Mishra UN, Thakur R, et al. Nutrient-mediated perception and signalling in human metabolism: a perspective of nutrigenomics. Int J Mol Sci. 2022 Sep 25;23(19):11305. doi: 10.1016/j.tifs.2024.104377.

Kaput J. Diet–disease gene interactions. Nutrition. 2004 Jan 1;20(1):26-31. doi: 10.1080/10408398.2022.2096563.

Meroni M, Longo M, Rustichelli A, Dongiovanni P. Nutrition and genetics in NAFLD: the perfect binomium. Int J Mol Sci. 2020 Apr 23;21(8):2986. doi: 10.1016/j.tifs.2009.05.005.

Brennan L, McNulty B. New technology in nutrition research and practice. Proceed Nutrition Soc. 2017 Aug;76(3):173-4. doi: 10.1016/j.tifs.2010.11.004.

Chirita-Emandi A, Niculescu M. Methods for global nutrigenomics and precision nutrition. In: DE Caterina R, Martinez JA, Kohlmeier M, Eds. Principles of Nutrigenetics and Nutrigenomics: Cambridge, MA: Academic Press 2020. pp. 49-58. doi: 10.1016/j.fufo.2024.100450.

Caradonna F, Consiglio O, Luparello C, Gentile C. Science and healthy meals in the world: Nutritional epigenomics and nutrigenetics of the mediterranean diet. Nutrients. 2020 Jun 11;12(6):1748. doi: 10.1016/j.tifs.2023.104284.

Aruoma OI, Hausman-Cohen S, Pizano J, Schmidt MA, Minich DM, Joffe Y, et al. Personalized nutrition: translating the science of nutrigenomics into practice: proceedings from the 2018 American College of Nutrition Meeting. J Am Coll Nutrit. 2019 May 19;38(4):287-301. doi: 10.1016/j.tifs.2016.06.001.

Alam I, Ali F, Zeb F, Almajwal A, Fatima S, Wu X. Relationship of nutrigenomics and aging: Involvement of DNA methylation. J Nutr Intermed Metab. 2019 Jun 1;16:100098. doi: 10.23880/fsnt-16000142.

Dang TS, Walker M, Ford D, Valentine RA. Nutrigenomics: the role of nutrients in gene expression. Periodontology 2000;2014 Feb;64(1):154-60. doi: 10.1016/j.tifs.2021.03.023.

Bordoni L, Petracci I, Zhao F, Min W, Pierella E, Assmann TS, Martinez JA, Gabbianelli R. Nutrigenomics of dietary lipids. Antioxidants. 2021 Jun 22;10(7):994. doi: 10.1016/j.tifs.2015.04.012.

Dahl WJ, Mendoza DR, Lambert JM. Diet, nutrients and the microbiome. Progress Mol Biol Trans Sci. 2020 Jan 1;171:237-63. doi: 10.1016/j.tifs.2017.05.018.

Barone M, D'Amico F, Brigidi P, Turroni S. Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins? Biofactors. 2022 Mar;48(2):307-14. doi: 10.1016/j.tifs.2019.11.009.

Reen JK, Yadav AK, Singh J. Nutrigenomics: concept, advances and applications. Asian J Dairy Food Res. 2015;34(3):205-12. doi: 10.1016/s0924-2244(00)00035-2.

Görman U, Ahlgren J, Nordström K. Ethical considerations in nutrigenetics and nutrigenomics. In: DE Caterina R, Martinez JA, Kohlmeier M, Eds. Principles of Nutrigenetics and Nutrigenomics: Cambridge, MA: Academic Press 2020. pp. 543-548. doi: 10.2174/157340131003140828121015.

Kizilaslan M, Arzik Y, Cinar MU, Konca Y. Genome-wise engineering of ruminant nutrition–nutrigenomics: applications, challenges, and future perspectives–A review. Annals Animal Sci. 2022 Apr 1;22(2):511-21. doi: 10.1016/j.tifs.2020.12.013.

Brennan L, de Roos B. Nutrigenomics: lessons learned and future perspectives. Am J Clin Nutrit. 2021 Mar 1;113(3):503-16. doi: 10.1016/0924-2244(94)90183-x.

Guest NS, Horne J, Vanderhout SM, El-Sohemy A. Sport nutrigenomics: personalized nutrition for athletic performance. Frontiers Nutrit. 2019 Feb 19;6:433157. doi: 10.1016/j.tifs.2018.07.015.

Marcum JA. Nutrigenetics/nutrigenomics, personalized nutrition, and precision healthcare. Current Nutrit Rep. 2020 Dec;9:338-45. doi: 10.1016/j.tifs.2022.07.008.

Kiani AK, Bonetti G, Donato K, Kaftalli J, Herbst KL, Stuppia L, et al. Polymorphisms, diet and nutrigenomics. J Prev Medicine Hygiene. 2022 Jun;63(2 Suppl 3):E125. doi: 10.1016/j.tifs.2023.104165.

Barrea L, Annunziata G, Bordoni L, Muscogiuri G, Colao A, Savastano S, Obesity Programs of Nutrition, Education, Research and Assessment (OPERA) Group. Nutrigenetics—personalized nutrition in obesity and cardiovascular diseases. In J Obesity Suppl. 2020 Jul;10(1):1-3. doi: 10.1016/s0924-2244(02)00019-5.

Simopoulos AP. Genetic variation and dietary response: nutrigenetics/nutrigenomics. Asia Pacific J Cln Nutrit. 2002 Oct;11:S117-28. doi: 10.1016/j.tifs.2005.03.003.

Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, et al. Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. Lifestyle Genomics. 2017 Jul 8;10(1-2):43-62. doi: 10.1016/j.tifs.2023.04.013.

Nasir A, Bullo MM, Ahmed Z, Imtiaz A, Yaqoob E, Safdar M, et al. Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review. Critical Rev Food Sci Nutrit. 2022 Mar 31;60(8):1375-87. doi: 10.1016/j.tifs.2011.03.004.

Kassem NM, Abdelmegid YA, El-Sayed MK, Sayed RS, Abdel-Aalla MH, Kassem HA. Nutrigenomics and microbiome shaping the future of personalized medicine: a review article. J Genetic Eng Biotechnol. 2023 Nov 22;21(1):134. doi: 10.1016/j.tifs.2021.06.045.

Di Renzo L, Gualtieri P, Romano L, Marrone G, Noce A, Pujia A, et al. Role of personalized nutrition in chronic-degenerative diseases. Nutrients. 2019 Jul 24;11(8):1707. doi: 10.1016/s0924-2244(97)01014-5.

Moore JB. From personalised nutrition to precision medicine: the rise of consumer genomics and digital health. Proceedings Nutrit Soc. 2020 Aug;79(3):300-10. doi: 10.1136/bmjnph-2021-000235.

Objavljeno
2025/08/29
Broj časopisa
Vol. 56 Br. 4 (2025): Jul-Aug
Rubrika
Aktuelna tema
Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).