Secretory breast carcinoma in adulthood – A case report with literature review

Tatjana  Ivković Kapicl; Ferenc  Vicko; Lazar  Popović; Dragana  Djilas; Tanja Lakić

doi:10.2298/VSP180126143I

Tatjana Ivković Kapicl Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Ferenc Vicko Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Lazar Popović The Institute of Oncology of Vojvodina, Sremska Kamenica
Dragana Djilas The Institute of Oncology of Vojvodina, Sremska Kamenica
Tanja Lakić University of Novi Sad, Faculty of Medicine, Clinical Center of Vojvodina

DOI: https://doi.org/10.2298/VSP180126143I

Keywords: breast neoplasms;, secretory breast carcinoma;, triple neg-ative breast neoplasms;, diagnosis;, mastectomy, segmen-tal;, adult

Abstract

Introduction. Secretory breast carcinoma is rare subtype of breast carcinoma which occurs primarily in children and young adults, so in the past it was called juvenile carcinoma. Case report. A 67-year-old female patient presented with mass of the right breast since one month. After physical, routine laboratory examination and mammography, core needle biopsy was performed and histopathological examination confirmed invasive carcinoma. Immunohistochemically, estrogen-receptors (ER) and progesteron-receptors (PR) showed weak positive reaction in 10% of tumor cells, while human epidermal growth factor receptor-2 (HER-2) was without expression. After an adequate preoperative preparation, operation was done – quadrantectomy with sentinel lymph node biopsy. Postoperatively, the patient was treated with 6 cycles of cyclophosphamide, methotrexate and fluorouracil (CMF) combination, radiotherapy (60 Gy) and tamoxifen. After 5-year follow-up the patient had no signs of the disease. Conclusion. Secretory breast cancer is a rare subtype of invasive breast carcinoma with wide age range of occurrence and good prognosis despite its triple-negative immunophenotype. Although the therapeutic management is non-consensual for this breast cancer special type, surgery is considered the mainstay of the treatment as well as the adjuvant chemotherapy and radiation.

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