Secretory breast carcinoma in adulthood – A case report with literature review

Tatjana  Ivković Kapicl; Ferenc  Vicko; Lazar  Popović; Dragana  Djilas; Tanja Lakić

doi:10.2298/VSP180126143I

Tatjana Ivković Kapicl Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Ferenc Vicko Institute of Oncology of Vojvodina, Sremska Kamenica, Serbia
Lazar Popović The Institute of Oncology of Vojvodina, Sremska Kamenica
Dragana Djilas The Institute of Oncology of Vojvodina, Sremska Kamenica
Tanja Lakić University of Novi Sad, Faculty of Medicine, Clinical Center of Vojvodina

DOI: https://doi.org/10.2298/VSP180126143I

Ključne reči: dojka, neoplazme;, dojka, sekretorni karcinom;, dojka, neoplazme, tripl negativne;, dijagnoza;, mastektomija, segmentalna;, odrasle osobe

Sažetak

Uvod. Sekretorni karcinom dojke je redak tip karcinoma dojke koji se prvenstveno javlja kod dece i mlađih odraslih osoba, zbog čega se u prošlosti nazivao juvenilnim karcinomom. Prikaz bolesnika. Žena, starosti 67 godina, javila se zbog palpabilne, bezbolne mase u desnoj dojci, koja se javila mesec dana pre prijema. Nakon fizikalnog pregleda, rutinskih laboratorijskih analiza i mamografije, načinjena je iglena biopsija i patohistološkom analizom dijagnostikovan je invazivni karcinom dojke. Imunohistohemijski, 10% tumorskih ćelija je pokazalo slabu pozitivnost na estrogenske i progesteronske receptore, dok je receptor humanog epidermalnog faktora rasta-2 (HER-2) bio negativan. Posle adekvatne preoperativne pripreme, izvršen je opertivni zahvat – kvadrantektomija sa biopsijom limfnog čvora stražara. Postoperativno, bolesnik je tertiran kombinacijom ciklofosfamid/metrotreksat/fluorouracil (6 ciklusa), radioterapijom (60 Gy) i tamoksifenom. Petogodišnjim praćenjem bolesnice nisu ustanovljeni znaci bolesti. Zaključak. Sekretorni karcinom dojke je redak tip karcinoma dojke, koji zahvata sve starosne grupe i ima dobru prognozu bez obzira na karakteristični tripl-negativni fenotip. Iako ne postoji standardizovan protokol lečenja, hirurška resekcija uz adjuvantnu hemoterapiju i zračnu terapiju su glavni terapijski postupci za ovaj tip karcinoma dojke.

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Sekretorni karcinom dojke u odraslom dobu

Sažetak

Reference