The Quality of life assessment in patients treated due to chronic pancreatitis

Saša Dragović; Maja  Vulović; Dušica  Stamenković; Nemanja  Rančić; Miroslav  Mitrović; Mihailo  Bezmarević; Milan  Jovanović; Ivan  Pantić; Zoran  Rujanovski; Sanja  Lepić; Boško  Milev

doi:10.2298/VSP201220054D

Saša Dragović Military Medical Academy, Clinic for General Surgery
Maja Vulović University of Kragujevac, Faculty of Medical Sciences, Department of Anatomy and Forensic Medicine, Kragujevac,
Dušica Stamenković Military Medical Academy, Clinic for Anaesthesiology and Intensive Care
Nemanja Rančić §University of Defence, Faculty of Medicine of the Military Medical Academy
Miroslav Mitrović Military Medical Academy, Clinic for General Surgery
Mihailo Bezmarević Military Medical Academy, Clinic for General Surgery
Milan Jovanović Military Medical Academy, Clinic for General Surgery
Ivan Pantić Military Medical Academy, Clinic for General Surgery
Zoran Rujanovski Military Medical Academy, Clinic for General Surgery
Sanja Lepić University of Defence, Faculty of Medicine of the Military Medical Academy
Boško Milev Military Medical Academy, Clinic for General Surgery

DOI: https://doi.org/10.2298/VSP201220054D

Keywords: drug therapy, pancreatitis, chronic, quality of life, surgical procedures, operative, surveys and questionnaires

Abstract

Background/Aim. Chronic pancreatitis (CP) causes inflammatory changes in the tissue of the pancreas, resulting in irreversible tissue damage. Pain, endocrine, and exocrine pancreatic insufficiency develop, thereby reducing the quality of life (QoL) of patients. The aim of the study was to determine the significance of surgical treatment in improving the QoL of patients with CP. Methods. QoL assessment of 50 patients diagnosed with CP was performed using a certified Euro Quality of Life-5 Dimension-5 Level (EuroQol-5D-5L) Questionnaire translated into Serbian. According to the method of treatment, patients completed the questionnaire. Patients were divided into two groups (conservatively treated – CT and surgically treated – ST), and all comparisons were made between groups. Results. Patients in stage B of CP were divided into two groups of 25 patients. The mean age in the ST group was 48.56 ± 11.91, and in the CT group was 51.08 ± 11.61 (p = 0.452). The male/female ratio in the ST group was 18/7, and in the CT group was 22/3 (p = 0.289). Pain in the ST group was present in 23 patients, and in the CT group was present in 18 patients (p = 0.141). Loss of appetite in the ST group was present in 7 patients and in the CT group in 10 patients (p = 0.256). Weight loss in both groups was equal (p = 1.000). Based on the EuroQol-5D-5L Questionnaire, significant differences were found (p < 0.001) between groups in Mobility and Pain/Discomfort, in Anxiety/Depression (p = 0.003), in Self-care (p = 0.004), and in Usual activities (p = 0.008). Conclusion. CP significantly reduces the QoL of patients treated either conservatively or by surgical approach. This study showed that surgical treatment is more beneficial for the QoL of patients with CP than the conservative approach.

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