Quality of life of women with polycystic ovary syndrome of reproductive age
Abstract
Background/Aim. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, and it affects their physical and mental health and their quality of life (QoL). The aim of this study was to assess the QoL of women with PCOS of reproductive age. Methods. The study included 100 women, aged 18 years or above, diagnosed with PCOS. The Short Form Health Survey-36 (SF-36) was used as the research instrument. Mann-Whitney U test, Kruskal-Wallis test, and Spearman’s rank correlation coefficient were used to examine possible differences in QoL within the variables studied. Results. Women with PCOS living in rural areas had a significantly higher mean score in the vitality domain. A statistically significant, strongly positive correlation with the total QoL score was found for the Mental Component Summary (MCS) (p < 0.001) and Physical Component Summary (PCS) (p < 0.001) subscales. A statistically significant but weak negative correlation was found between self-rated health and the PCS (p = 0.021), the MCS (p = 0.004) and the total QoL score (p = 0.002), and age with the PCS (p = 0.023) and the total QoL score (p = 0.032). Conclusion. Women with PCOS in rural areas were more vital and had better QoL. Lower self-esteem regarding health is associated with poorer QoL, especially in the psychological domain. In women with manifest PCOS, early diagnosis and appropriate education can help alleviate certain symptoms and prevent serious complications.
References
Behboodi Moghadam Z, Fereidooni B, Saffari M, Montazeri A. Measures of health-related quality of life in PCOS women: a systematic review. Int J Womens Health 2018; 10: 397−408. DOI: 10.2147/IJWH.S165794.
Islam H, Masud J, Islam YN, Haque FK. An update on polycys-tic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treat-ment options. Womens Health (Lond) 2022; 18: 17455057221117966. DOI: 10.1177/17455057221117966.
Miazgowski T, Martopullo I, Widecka J, Miazgowski B, Brodowska A. National and regional trends in the prevalence of polycystic ovary syndrome since 1990 within Europe: the modeled esti-mates from the Global Burden of Disease Study 2016. Arch Med Sci 2019; 17(2): 343−51. DOI: 10.5114/aoms.2019.87112.
Martin ML, Halling K, Eek D, Krohe M, Paty J. Understanding polycystic ovary syndrome from the patient perspective: a concept elicitation patient interview study. Health Qual Life Outcomes 2017; 15(1): 162. DOI: 10.1186/s12955-017-0736-3.
Smet ME, McLennan A. Rotterdam criteria, the end. Australas J Ultrasound Med 2018; 21(2): 59−60. DOI: 10.1002/ajum.12096.
Mumusoglu S, Yildiz BO. Polycystic ovary syndrome pheno-types and prevalence: Differential impact of diagnostic criteria and clinical versus unselected population. Curr Opin Endocr Metab Res 2020; 12: 66−71. DOI:10.1016/j.coemr.2020.03.004.
Bulsara J, Patel P, Soni A, Acharya S. A review: Brief insight in-to polycystic ovarian syndrome. Endocr Metab Sci 2021; 3: 100085. DOI: 10.1016/j.endmts.2021.100085.
Azziz R, Carmina E, Chen Z, Dunaif A, Laven JSE, Legro RS, et al. Polycystic ovary syndrome. Nat Rev Dis Primers 2016; 2: 16057. DOI: 10.1038/nrdp.2016.57.
Louwers YV, Laven JSE. Characteristics of polycystic ovary syndrome throughout life. Ther Adv Reprod Health 2020; 14: 2633494120911038. DOI: 10.1177/2633494120911038.
Agrawal A 4th, Dave A, Jaiswal A. Type 2 Diabetes Mellitus in Patients With Polycystic Ovary Syndrome. Cureus 2023; 15(10): e46859. DOI: 10.7759/cureus.46859.
Pililis S, Lampsas S, Kountouri A, Pliouta L, Korakas E, Livadas S, et al. The cardiometabolic risk in women with polycystic ovarian syndrome (PCOS): From pathophysiology to diagnosis and treatment. Medicina (Kaunas) 2024; 60(10): 1656. DOI: 10.3390/medicina60101656.
Amiri M, Bidhendi-Yarandi R, Fallahzadeh A, Marzban Z, Ramezani Tehrani F. Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A system-atic review and meta-analysis. Int J Reprod Biomed 2022; 20(11): 893−914. DOI: 10.18502/ijrm.v20i11.12357.
He J, Ruan X, Li J. Polycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis. Front Endocrinol (Lausanne) 2024; 15: 1418933. DOI: 10.3389/fendo.2024.1418933.
Li M, He Z, Shi L, Lin M, Li M, Cheng Y, et al. Intelligent de-tection for Polycystic Ovary Syndrome (PCOS): Taxonomy, datasets and detection tools. Comput Struct Biotechnol J 2025; 27: 1578−99. DOI: 10.1016/j.csbj.2025.04.011.
Chauhan P, Patil P, Rane N, Raundale P, Kanakia H. Compara-tive Analysis of Machine Learning Algorithms for Prediction of PCOS. 2021 International Conference on Communication information and Computing Technology (ICCICT), Mumbai, India; 2021. p.1−7. DOI: 10.1109/ICCICT50803.2021.9510128.
Žikić O, Cvetanović A, Kostić J, Nikolić G, Stojanov J, Binić I. Men-tal health and quality of life of female breast cancer survivors in southeast Serbia. Vojnosanit Pregl 2024; 81(9): 570–8. DOI: 10.2298/VSP240413049Z.
Rzońca E, Bień A, Wdowiak A, Szymański R, Iwanowicz-Palus G. Determinants of quality of life and satisfaction with life in women with polycystic ovary syndrome. Int J Environ Res Public Health 2018; 15(2): 376. DOI: 10.3390/ijerph15020376.
World Health Organization. WHOQOL: Measuring Quality of Life. Geneva: WHO; 2025 [cited 2025 May 16; accessed 2025 May 10]. Available from: https://www.who.int/tools/whoqol
Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? Pharmacoeconomics 2016; 34(7): 645−9. DOI: 10.1007/s40273-016-0389-9.
Kaczmarek C, Haller DM, Yaron M. Health-Related Quality of Life in Adolescents and Young Adults with Polycystic Ovary Syndrome: A Systematic Review. J Pediatr Adolesc Gynecol 2016; 29(6): 551−7. DOI: 10.1016/j.jpag.2016.05.006.
Sánchez-Ferrer ML, Adoamnei E, Prieto-Sánchez MT, Mendiola J, Corbalán-Biyang S, Moñino-García M, et al. Health-related quali-ty of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: A case-control study. Health Qual Life Outcomes 2020; 18(1): 232. DOI: 10.1186/s12955-020-01484-z.
Yin S, Njai R, Barker L, Siegel PZ, Liao Y. Summarizing health-related quality of life (HRQOL): Development and testing of a one-factor model. Popul Health Metr 2016; 14: 22. DOI: 10.1186/s12963-016-0091-3.
Tabassum F, Jyoti C, Sinha HH, Dhar K, Akhtar MS. Impact of polycystic ovary syndrome on quality of life of women in cor-relation to age, basal metabolic index, education and marriage. PLoS One 2021; 16(3): e0247486. DOI: 10.1371/journal.pone.0247486.
Khomami MB, Tehrani FR, Hashemi S, Farahmand M, Azizi F. Of PCOS Symptoms, hirsutism has the most significant im-pact on the quality of life of Iranian women. PLoS One 2015; 10(4): e0123608. DOI: 10.1371/journal.pone.0123608.
Bazarganipour F, Ziaei S, Montazeri A, Foroozanfard F, Kazemnejad A, Faghihzadeh S. Health-related quality of life in patients with polycystic ovary syndrome (PCOS): a model-based study of predictive factors. J Sex Med 2014; 11(4): 1023−32. DOI: 10.1111/jsm.12405.
Angin P, Yoldemir T, Atasayan K. Quality of life among infertile PCOS patients. Arch Gynecol Obstet 2019; 300(2): 461−7. DOI: 10.1007/s00404-019-05202-z.
Barberis N, Calaresi D, Cannavò M, Verrastro V. Body mass in-dex and quality of life in individuals with polycystic ovary syndrome: Dysmorphic concerns and eating disorders as medi-ators. Front Public Health 2022; 10: 962083. DOI: 10.3389/fpubh.2022.962083.
Dybciak P, Humeniuk E, Raczkiewicz D, Krakowiak J, Wdowiak A, Bojar I. Anxiety and Depression in Women with Polycystic Ovary Syndrome. Medicina (Kaunas) 2022; 58(7): 942. DOI: 10.3390/medicina58070942.
Pinto J, Cera N, Pignatelli D. Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: A narrative review. J Endocrinol Invest 2024; 47(7): 1−22. DOI: 10.1007/s40618-024-02329-y.
Bazarganipour F, Ziaei S, Montazeri A, Foroozanfard F, Faghihza-deh S. Iranian version of modified polycystic ovary syndrome health-related quality of Life questionnaire: Discriminant and convergent validity. Iran J Reprod Med 2013; 11(9): 753−60.
Teoli D, Bhardwaj A. Quality of life [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Mar 27 [cited 2025 May 16; accessed 2025 Jun 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547711/
Hernández-Segura N, Marcos-Delgado A, Pinto-Carral A, Fernán-dez-Villa T, Molina AJ. Health-Related Quality of Life (HRQOL) Instruments and Mobility: A Systematic Review. Int J Environ Res Public Health 2022; 19(24): 16493. DOI: 10.3390/ijerph192416493.
Jones GL, Hall JM, Lashen HL, Balen AH, Ledger WL. Health-related quality of life among adolescents with polycystic ovary syndrome. J Obstet Gynecol Neonatal Nurs 2011; 40(5): 577−88. DOI: 10.1111/j.1552-6909.2011.01279.x.
Latas M, Stojković T, Ralić T, Jovanović S, Spirić Ž, Milovanović S. Medical students' health-related quality of life: A comparative study. Vojnosanit Pregl 2014; 71(8): 751−6. DOI: 10.2298/vsp1408751l.
Lins L, Carvalho FM. SF-36 total score as a single measure of health-related quality of life: Scoping review. SAGE Open Med 2016; 4: 2050312116671725. DOI: 10.1177/2050312116671725.
Marn-Vukadinović D, Jamnik H. Validation of the short form-36 health survey supported with isokinetic strength testing af-ter sport knee injury. J Sport Rehabil 2011; 20(3): 261−76. DOI: 10.1123/jsr.20.3.261.
Dey P. Quality of life of women with polycystic ovarian syn-drome. Int J Reprod Contracept Obstet Gynecol 2018; 7(7): 2586−9. DOI: 10.18203/2320-1770.ijrcog20182447.
Wang J, Wang B, Li C, Meng T, Liu C, Chen J, et al. Evolving global trends in PCOS burden: A three-decade analysis (1990-2021) with projections to 2036 among adolescents and young adults. Front Endocrinol (Lausanne) 2025; 16: 1569694. DOI: 10.3389/fendo.2025.1569694.
Lin T, Xie B, Yang J, Xu J, Chen F. Changes in the global bur-den of polycystic ovary syndrome from 1990 to 2021. Reprod Health 2025; 22(1): 86. DOI: 10.1186/s12978-025-02016-y.
Ligocka N, Chmaj-Wierzchowska K, Wszołek K, Wilczak M, Tomczyk K. Quality of Life of Women with Polycystic Ovary Syndrome. Medicina (Kaunas) 2024; 60(2): 294. DOI: 10.3390/medicina60020294.
Panico A, Messina G, Lupoli GA, Lupoli R, Cacciapuoti M, Mosca-telli F, et al. Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome. Patient Prefer Adherence 2017; 11: 423−9. DOI: 10.2147/ppa.s119180.
Gnawali A, Patel V, Cuello-Ramírez A, Al Kaabi AS, Noor A, Rashid MY, et al. Why are Women With Polycystic Ovary Syndrome at Increased Risk of Depression? Exploring the Etiological Maze. Cureus 2021; 13(2): e13489. DOI: 10.7759/cureus.13489.
Lu KT, Ho YC, Chang CL, Lan KC, Wu CC, Su YT. Evalua-tion of bodily pain associated with polycystic ovary syndrome: A review of health-related quality of life and potential risk factors. Biomedicines 2022; 10(12): 3197. DOI: 10.3390/biomedicines10123197.
Borghi L, Leone D, Vegni E, Galiano V, Lepadatu C, Sulpizio P, et al. Psychological distress, anger and quality of life in poly-cystic ovary syndrome: Associations with biochemical, pheno-typical and socio-demographic factors. J Psychosom Obstet Gynaecol 2018; 39(2): 128−37. DOI: 10.1080/0167482x.2017.1311319.
Dybciak P, Raczkiewicz D, Humeniuk E, Powrózek T, Gujski M, Małecka-Massalska T, et al. Depression in polycystic ovary syndrome: A systematic review and meta-analysis. J Clin Med 2023; 12(20): 6446. DOI: 10.3390/jcm12206446.
Ozcan Dag Z, Alpua M, Isik Y, Buturak SV, Tulmac OB, Turkel Y. The evaluation of temperament and quality of life in pa-tients with polycystic ovary syndrome. Gynecol Endocrinol 2017; 33(3): 250−3. DOI: 10.1080/09513590.2016.1254610.
Ismayilova M, Yaya S. What can be done to improve polycystic ovary syndrome (PCOS) healthcare? Insights from semi-structured interviews with women in Canada. BMC Women's Health 2022; 22(1): 157. DOI: 10.1186/s12905-022-01734-w.
Dashti S, Abdul Hamid H, Mohamad Saini S, Tusimin M, Ismail M, Jafarzadeh Esfehani A, et al. A randomised controlled trial on the effects of a structural education module among women with polycystic ovarian syndrome on nutrition and physical ac-tivity changes. BMC Womens Health 2022; 22(1): 277. DOI: 10.1186/s12905-022-01861-4.
Shereda HMA, Shokr EA, Radwan HA, Alqersh DLA, Hashem SR, Konsouh AME, et al. Effect of bio-psychosocial nursing in-tervention on emotional status, body image, and quality of life of women with polycystic ovarian syndrome: a quasi-experimental study. BMC Nurs 2025; 24(1): 887. DOI: 10.1186/s12912-025-03483-1.
