Kvalitet života žena u reproduktivnom dobu koje imaju sindrom policističnih jajnika
Sažetak
Uvod/Cilj. Sindrom policističnih jajnika (polycystic ovary syndrome – PCOS) je najčešći endokrini poremećaj žena u reproduktivnom dobu i utiče na njihovo fizičko i mentalno zdravlje i na kvalitet života (quality of life – QoL). Cilj rada bio je da se proceni QoL žena u reproduktivnom periodu koje imaju PCOS. Metode. Istraživanjem je obuhvaćeno 100 žena starijih od 18 godina, kojima je dijagnostikovan PCOS. Kao instrument istraživanja korišćen je upitnik Short Form Health Survey-36 (SF-36). Za ispitivanje mogućih razlika u QoL u odnosu na ispitivane varijable, korišćeni su Mann-Whitney U test, Kruskal-Wallis test i Spearman-ov koeficijent korelacije. Rezultati. Žene koje imaju PCOS i žive u ruralnim sredinama imale su značajno viši prosečni rezultat u domenu vitalnosti. Statistički značajna, jaka pozitivna korelacija sa ukupnim rezultatom QoL utvrđena je za podskale Mental Component Summary (MCS) (p < 0,001) i Physical Component Summary (PCS) (p < 0,001). Utvrđena je statistički značajna, ali slaba negativna korelacija između samoprocene zdravlja i PCS (p = 0,021), MCS (p = 0,004) i ukupnog skora QoL (p = 0,002), kao i između životnog doba i PCS (p = 0,023) i ukupnog skora QoL (p = 0,032). Zaključak. Žene u ruralnim područjima koje imaju PCOS bile su vitalnije i imale su bolji QoL. Niže samopouzdanje u vezi sa zdravljem povezano je sa lošijim QoL, posebno u psihološkom domenu. Kod žena sa ispoljenim PCOS se, uz ranu dijagnozu i odgovarajuću edukaciju, mogu ublažiti pojedini simptomi i sprečiti teške komplikacije.
Reference
Behboodi Moghadam Z, Fereidooni B, Saffari M, Montazeri A. Measures of health-related quality of life in PCOS women: a systematic review. Int J Womens Health 2018; 10: 397−408. DOI: 10.2147/IJWH.S165794.
Islam H, Masud J, Islam YN, Haque FK. An update on polycys-tic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treat-ment options. Womens Health (Lond) 2022; 18: 17455057221117966. DOI: 10.1177/17455057221117966.
Miazgowski T, Martopullo I, Widecka J, Miazgowski B, Brodowska A. National and regional trends in the prevalence of polycystic ovary syndrome since 1990 within Europe: the modeled esti-mates from the Global Burden of Disease Study 2016. Arch Med Sci 2019; 17(2): 343−51. DOI: 10.5114/aoms.2019.87112.
Martin ML, Halling K, Eek D, Krohe M, Paty J. Understanding polycystic ovary syndrome from the patient perspective: a concept elicitation patient interview study. Health Qual Life Outcomes 2017; 15(1): 162. DOI: 10.1186/s12955-017-0736-3.
Smet ME, McLennan A. Rotterdam criteria, the end. Australas J Ultrasound Med 2018; 21(2): 59−60. DOI: 10.1002/ajum.12096.
Mumusoglu S, Yildiz BO. Polycystic ovary syndrome pheno-types and prevalence: Differential impact of diagnostic criteria and clinical versus unselected population. Curr Opin Endocr Metab Res 2020; 12: 66−71. DOI:10.1016/j.coemr.2020.03.004.
Bulsara J, Patel P, Soni A, Acharya S. A review: Brief insight in-to polycystic ovarian syndrome. Endocr Metab Sci 2021; 3: 100085. DOI: 10.1016/j.endmts.2021.100085.
Azziz R, Carmina E, Chen Z, Dunaif A, Laven JSE, Legro RS, et al. Polycystic ovary syndrome. Nat Rev Dis Primers 2016; 2: 16057. DOI: 10.1038/nrdp.2016.57.
Louwers YV, Laven JSE. Characteristics of polycystic ovary syndrome throughout life. Ther Adv Reprod Health 2020; 14: 2633494120911038. DOI: 10.1177/2633494120911038.
Agrawal A 4th, Dave A, Jaiswal A. Type 2 Diabetes Mellitus in Patients With Polycystic Ovary Syndrome. Cureus 2023; 15(10): e46859. DOI: 10.7759/cureus.46859.
Pililis S, Lampsas S, Kountouri A, Pliouta L, Korakas E, Livadas S, et al. The cardiometabolic risk in women with polycystic ovarian syndrome (PCOS): From pathophysiology to diagnosis and treatment. Medicina (Kaunas) 2024; 60(10): 1656. DOI: 10.3390/medicina60101656.
Amiri M, Bidhendi-Yarandi R, Fallahzadeh A, Marzban Z, Ramezani Tehrani F. Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A system-atic review and meta-analysis. Int J Reprod Biomed 2022; 20(11): 893−914. DOI: 10.18502/ijrm.v20i11.12357.
He J, Ruan X, Li J. Polycystic ovary syndrome in obstructive sleep apnea-hypopnea syndrome: an updated meta-analysis. Front Endocrinol (Lausanne) 2024; 15: 1418933. DOI: 10.3389/fendo.2024.1418933.
Li M, He Z, Shi L, Lin M, Li M, Cheng Y, et al. Intelligent de-tection for Polycystic Ovary Syndrome (PCOS): Taxonomy, datasets and detection tools. Comput Struct Biotechnol J 2025; 27: 1578−99. DOI: 10.1016/j.csbj.2025.04.011.
Chauhan P, Patil P, Rane N, Raundale P, Kanakia H. Compara-tive Analysis of Machine Learning Algorithms for Prediction of PCOS. 2021 International Conference on Communication information and Computing Technology (ICCICT), Mumbai, India; 2021. p.1−7. DOI: 10.1109/ICCICT50803.2021.9510128.
Žikić O, Cvetanović A, Kostić J, Nikolić G, Stojanov J, Binić I. Men-tal health and quality of life of female breast cancer survivors in southeast Serbia. Vojnosanit Pregl 2024; 81(9): 570–8. DOI: 10.2298/VSP240413049Z.
Rzońca E, Bień A, Wdowiak A, Szymański R, Iwanowicz-Palus G. Determinants of quality of life and satisfaction with life in women with polycystic ovary syndrome. Int J Environ Res Public Health 2018; 15(2): 376. DOI: 10.3390/ijerph15020376.
World Health Organization. WHOQOL: Measuring Quality of Life. Geneva: WHO; 2025 [cited 2025 May 16; accessed 2025 May 10]. Available from: https://www.who.int/tools/whoqol
Karimi M, Brazier J. Health, health-related quality of life, and quality of life: what is the difference? Pharmacoeconomics 2016; 34(7): 645−9. DOI: 10.1007/s40273-016-0389-9.
Kaczmarek C, Haller DM, Yaron M. Health-Related Quality of Life in Adolescents and Young Adults with Polycystic Ovary Syndrome: A Systematic Review. J Pediatr Adolesc Gynecol 2016; 29(6): 551−7. DOI: 10.1016/j.jpag.2016.05.006.
Sánchez-Ferrer ML, Adoamnei E, Prieto-Sánchez MT, Mendiola J, Corbalán-Biyang S, Moñino-García M, et al. Health-related quali-ty of life in women with polycystic ovary syndrome attending to a tertiary hospital in Southeastern Spain: A case-control study. Health Qual Life Outcomes 2020; 18(1): 232. DOI: 10.1186/s12955-020-01484-z.
Yin S, Njai R, Barker L, Siegel PZ, Liao Y. Summarizing health-related quality of life (HRQOL): Development and testing of a one-factor model. Popul Health Metr 2016; 14: 22. DOI: 10.1186/s12963-016-0091-3.
Tabassum F, Jyoti C, Sinha HH, Dhar K, Akhtar MS. Impact of polycystic ovary syndrome on quality of life of women in cor-relation to age, basal metabolic index, education and marriage. PLoS One 2021; 16(3): e0247486. DOI: 10.1371/journal.pone.0247486.
Khomami MB, Tehrani FR, Hashemi S, Farahmand M, Azizi F. Of PCOS Symptoms, hirsutism has the most significant im-pact on the quality of life of Iranian women. PLoS One 2015; 10(4): e0123608. DOI: 10.1371/journal.pone.0123608.
Bazarganipour F, Ziaei S, Montazeri A, Foroozanfard F, Kazemnejad A, Faghihzadeh S. Health-related quality of life in patients with polycystic ovary syndrome (PCOS): a model-based study of predictive factors. J Sex Med 2014; 11(4): 1023−32. DOI: 10.1111/jsm.12405.
Angin P, Yoldemir T, Atasayan K. Quality of life among infertile PCOS patients. Arch Gynecol Obstet 2019; 300(2): 461−7. DOI: 10.1007/s00404-019-05202-z.
Barberis N, Calaresi D, Cannavò M, Verrastro V. Body mass in-dex and quality of life in individuals with polycystic ovary syndrome: Dysmorphic concerns and eating disorders as medi-ators. Front Public Health 2022; 10: 962083. DOI: 10.3389/fpubh.2022.962083.
Dybciak P, Humeniuk E, Raczkiewicz D, Krakowiak J, Wdowiak A, Bojar I. Anxiety and Depression in Women with Polycystic Ovary Syndrome. Medicina (Kaunas) 2022; 58(7): 942. DOI: 10.3390/medicina58070942.
Pinto J, Cera N, Pignatelli D. Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: A narrative review. J Endocrinol Invest 2024; 47(7): 1−22. DOI: 10.1007/s40618-024-02329-y.
Bazarganipour F, Ziaei S, Montazeri A, Foroozanfard F, Faghihza-deh S. Iranian version of modified polycystic ovary syndrome health-related quality of Life questionnaire: Discriminant and convergent validity. Iran J Reprod Med 2013; 11(9): 753−60.
Teoli D, Bhardwaj A. Quality of life [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Mar 27 [cited 2025 May 16; accessed 2025 Jun 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547711/
Hernández-Segura N, Marcos-Delgado A, Pinto-Carral A, Fernán-dez-Villa T, Molina AJ. Health-Related Quality of Life (HRQOL) Instruments and Mobility: A Systematic Review. Int J Environ Res Public Health 2022; 19(24): 16493. DOI: 10.3390/ijerph192416493.
Jones GL, Hall JM, Lashen HL, Balen AH, Ledger WL. Health-related quality of life among adolescents with polycystic ovary syndrome. J Obstet Gynecol Neonatal Nurs 2011; 40(5): 577−88. DOI: 10.1111/j.1552-6909.2011.01279.x.
Latas M, Stojković T, Ralić T, Jovanović S, Spirić Ž, Milovanović S. Medical students' health-related quality of life: A comparative study. Vojnosanit Pregl 2014; 71(8): 751−6. DOI: 10.2298/vsp1408751l.
Lins L, Carvalho FM. SF-36 total score as a single measure of health-related quality of life: Scoping review. SAGE Open Med 2016; 4: 2050312116671725. DOI: 10.1177/2050312116671725.
Marn-Vukadinović D, Jamnik H. Validation of the short form-36 health survey supported with isokinetic strength testing af-ter sport knee injury. J Sport Rehabil 2011; 20(3): 261−76. DOI: 10.1123/jsr.20.3.261.
Dey P. Quality of life of women with polycystic ovarian syn-drome. Int J Reprod Contracept Obstet Gynecol 2018; 7(7): 2586−9. DOI: 10.18203/2320-1770.ijrcog20182447.
Wang J, Wang B, Li C, Meng T, Liu C, Chen J, et al. Evolving global trends in PCOS burden: A three-decade analysis (1990-2021) with projections to 2036 among adolescents and young adults. Front Endocrinol (Lausanne) 2025; 16: 1569694. DOI: 10.3389/fendo.2025.1569694.
Lin T, Xie B, Yang J, Xu J, Chen F. Changes in the global bur-den of polycystic ovary syndrome from 1990 to 2021. Reprod Health 2025; 22(1): 86. DOI: 10.1186/s12978-025-02016-y.
Ligocka N, Chmaj-Wierzchowska K, Wszołek K, Wilczak M, Tomczyk K. Quality of Life of Women with Polycystic Ovary Syndrome. Medicina (Kaunas) 2024; 60(2): 294. DOI: 10.3390/medicina60020294.
Panico A, Messina G, Lupoli GA, Lupoli R, Cacciapuoti M, Mosca-telli F, et al. Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome. Patient Prefer Adherence 2017; 11: 423−9. DOI: 10.2147/ppa.s119180.
Gnawali A, Patel V, Cuello-Ramírez A, Al Kaabi AS, Noor A, Rashid MY, et al. Why are Women With Polycystic Ovary Syndrome at Increased Risk of Depression? Exploring the Etiological Maze. Cureus 2021; 13(2): e13489. DOI: 10.7759/cureus.13489.
Lu KT, Ho YC, Chang CL, Lan KC, Wu CC, Su YT. Evalua-tion of bodily pain associated with polycystic ovary syndrome: A review of health-related quality of life and potential risk factors. Biomedicines 2022; 10(12): 3197. DOI: 10.3390/biomedicines10123197.
Borghi L, Leone D, Vegni E, Galiano V, Lepadatu C, Sulpizio P, et al. Psychological distress, anger and quality of life in poly-cystic ovary syndrome: Associations with biochemical, pheno-typical and socio-demographic factors. J Psychosom Obstet Gynaecol 2018; 39(2): 128−37. DOI: 10.1080/0167482x.2017.1311319.
Dybciak P, Raczkiewicz D, Humeniuk E, Powrózek T, Gujski M, Małecka-Massalska T, et al. Depression in polycystic ovary syndrome: A systematic review and meta-analysis. J Clin Med 2023; 12(20): 6446. DOI: 10.3390/jcm12206446.
Ozcan Dag Z, Alpua M, Isik Y, Buturak SV, Tulmac OB, Turkel Y. The evaluation of temperament and quality of life in pa-tients with polycystic ovary syndrome. Gynecol Endocrinol 2017; 33(3): 250−3. DOI: 10.1080/09513590.2016.1254610.
Ismayilova M, Yaya S. What can be done to improve polycystic ovary syndrome (PCOS) healthcare? Insights from semi-structured interviews with women in Canada. BMC Women's Health 2022; 22(1): 157. DOI: 10.1186/s12905-022-01734-w.
Dashti S, Abdul Hamid H, Mohamad Saini S, Tusimin M, Ismail M, Jafarzadeh Esfehani A, et al. A randomised controlled trial on the effects of a structural education module among women with polycystic ovarian syndrome on nutrition and physical ac-tivity changes. BMC Womens Health 2022; 22(1): 277. DOI: 10.1186/s12905-022-01861-4.
Shereda HMA, Shokr EA, Radwan HA, Alqersh DLA, Hashem SR, Konsouh AME, et al. Effect of bio-psychosocial nursing in-tervention on emotional status, body image, and quality of life of women with polycystic ovarian syndrome: a quasi-experimental study. BMC Nurs 2025; 24(1): 887. DOI: 10.1186/s12912-025-03483-1.