Dried blood spot: utilising dry blood for pharmacokinetic investigations – an old method with great future for therapeutic  drug monitoring

Svetlana Goločorbin-Kon; Momir Mikov; Jelena Cvejić Hogervorst; Hani Al-Salami; Vladimir Maksimović

doi:10.2298/VSP170130046G

Svetlana Goločorbin-Kon University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia
Momir Mikov University of Novi Sad, Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad, Serbia
Jelena Cvejić Hogervorst University of Novi Sad, Faculty of Medicine, Department of Pharmacy, Novi Sad, Serbia
Hani Al-Salami Curtin University, School of Pharmacy, Biotechnology and Drug Development Research Laboratory, Perth WA, Australia
Vladimir Maksimović University of Novi Sad, Faculty of Medicine, Department of Pharmacology, Novi Sad, Serbia

DOI: https://doi.org/10.2298/VSP170130046G

Keywords: dried blood spot testing;, chromatography, liquid;, mass spectrometry;, pharmacokinetics;, therapeutic equivalence;, metabolic diseases;, neonatology;, hiv.

References

Guthrie R, Susi A. A simple phenylalanine method for detect-ing phenylketonuria in large populations of newborn infants. Pedi¬atrics 1963; 32: 338–43.

Lehmann S, Delaby C, Vialaret J, Ducos J, Hirtz C. Current and fu¬ture use of "dried blood spot" analyses in clinical chemistry. Clin Chem Lab Med 2013; 51(10): 1897–909.

Liao HW, Lin SW, Chen GY, Kuo CH. Estimation and Correc-tion of the Blood Volume Variations of Dried Blood Spots Using a Postcolumn Infused-Internal Standard Strategy with LC-Electrospray Ionization-MS. Anal Chem 2016; 88(12): 6457–64.

Kyriakou C, Marchei E, Scaravelli G, García-Algar O, Supervía A, Graziano S. Identification and quantification of psychoactive drugs in whole blood using dried blood spot (DBS) by ultra-performance liquid chromatography tandem mass spectrome-try. J Pharm Biomed Anal 2016; 128: 53–60.

Rao RN. Emerging liquid chromatography-mass spectrometry technologies improving dried blood spot analysis. Expert Rev Proteomics 2014; 11(4): 425–30.

Kothare PA, Bateman KP, Dockendorf M, Stone J, Xu Y, Woolf E, et al. An Integrated Strategy for Implementation of Dried Blood Spots in Clinical Development Programs. AAPS J 2016; 18(2): 519–27.

Sakhi AK, Bastani NE, Ellingjord-Dale M, Gundersen TE, Blomhoff R, Ursin G. Feasibility of self-sampled dried blood spot and sa¬liva samples sent by mail in a population-based study. BMC Cancer 2015; 15: 265.

Wilhelm AJ, den Burger JC, Swart EL. Therapeutic drug moni-tor¬ing by dried blood spot: progress to date and future direc-tions. Clin Pharmacokinet 2014; 53(11): 961–73.

Vacchina V, Huin V, Hulo S, Cuny D, Broly F, Renom G, et al. Use of dried blood spots and inductively coupled plasma mass spectrometry for multi-element determination in blood. J Trace Elem Med Biol 2014; 28(3): 255–9.

Odoardi S, Anzillotti L, Strano-Rossi S. Simplifying sample pre-treatment: application of dried blood spot (DBS) method to blood samples, including postmortem, for UHPLC-MS/MS analysis of drugs of abuse. Forensic Sci Int 2014; 243: 61–7.

Velickovic-Radovanovic RM, Paunovic G, Mikov M, Djordjevic V, Sto¬janovic M, Catic-Djordjevic A, et al. Clinical pharmacokinetics of tacrolimus after the first oral administration in renal trans-plant recipients on triple immunosuppressive therapy. Basic Clin Pharmacol Toxicol 2010; 106(6): 505–10.

Velickovic-Radovanovic R, Mikov M, Catic-Djordjevic A, Stefanovic N, Mitic B, Paunovic G, et al. Gender-dependent predictable pharmacokinetic method for tacrolimus exposure monitoring in kidney transplant patients. Eur J Drug Metab Pharmacoki-net 2015; 40(1): 95–102.

Rančić N, Dragojević-Simić V, Vavić N, Kovačević A, Šegrt Z, Drašk¬ović-Pavlović B, et al. Tacrolimus concentration/dose ratio as a therapeutic drug monitoring strategy: the influence of gender and comedication. Vojnosanit Pregl 2015; 72(9): 813–22.

Marques BL, do Espírito-Santo MP, Marques VA, Miguel JC, da Silva EF, Villela-Nogueira CA, et al. Evaluation of dried blood spot samples for hepatitis C virus detection and quantifica-tion. J Clin Virol 2016; 82: 139–44

Greenman J, Roberts T, Cohn J, Messac L. Dried blood spot in the genotyping, quantification and storage of HCV RNA: a sys¬tematic literature review. J Viral Hepat 2015; 22(4): 353–61.

Milosheska D, Grabnar I, Vovk T. Dried blood spots for moni-toring and individualization of antiepileptic drug treatment. Eur J Pharm Sci 2015; 75: 25–39.

Shah NM, Hawwa AF, Millership JS, Collier PS, Ho P, Tan ML, et al. Adherence to antiepileptic medicines in children: a mul-tiple-methods assessment involving dried blood spot sampling. Epilepsia 2013; 54(6): 1020–7.

Hawwa AF, AlBawab A, Rooney M, Wedderburn LR, Beresford MW, McElnay JC. Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with ju-venile idiopathic arthritis and juvenile dermatomyositis: an ob¬servational, cross-sectional study. Arthritis Res Ther 2015; 17: 295.

Hawwa AF, Albawab A, Rooney M, Wedderburn LR, Beresford MW, McElnay JC. A novel dried blood spot-LCMS method for the quantification of methotrexate polyglutamates as a po-ten¬tial marker for methotrexate use in children. PLoS One 2014; 9(2): e89908.

Chen G, Fawcett JP, Mikov M, Tucker IG. Simultaneous deter-mina¬tion of methotrexate and its polyglutamate metabo¬lites in Caco-2 cells by liquid chromatography-tandem mass spec-trometry. J Pharm Biomed Anal 2009; 50(2): 262–6.

Chen G, Fawcett JP, Mikov M, Tucker IG. Monoketocholate can decrease transcellular permeation of methotrexate across Ca-co-2 cell monolayers and reduce its intestinal absorption in rat. J Pharm Pharmacol 2009; 61(7): 953–9.

Enderle Y, Foerster K, Burhenne J. Clinical feasibility of dried blood spots: Analytics, validation, and applications. J Pharm Biomed Anal 2016; 130: 231–43.

Briscoe CJ, Hage DS. Factors affecting the stability of drugs and drug metabolites in biological matrices. Bioanalysis 2009; 1(1): 205–20.

Antunes MV, Charão MF, Linden R. Dried blood spots analysis with mass spectrometry: Potentials and pitfalls in therapeutic drug monitoring. Clin Biochem 2016; 49(13–14): 1035–46.

Capiau S, Wilk LS, Aalders MC, Stove CP. A Novel, Nonde-struc¬tive, Dried Blood Spot-Based Hematocrit Predic¬tion Method Using Noncontact Diffuse Reflectance Spectros¬copy. Anal Chem 2016; 88(12): 6538–46.

Tanna S, Lawson G. Dried blood spot analysis to assess medica-tion adherence and to inform personalization of treatment. Bioanalysis 2014; 6(21): 2825–38.

Wagner M, Tonoli D, Varesio E, Hopfgartner G. The use of mass spectrometry to analyze dried blood spots. Mass Spectrom Rev 2016; 35(3): 361–438.