Određivanje specifičnosti, senzitivnosti i tačnosti biopsije šupljom iglom u dijagnostikovanju tumora doušne i podvilične pljuvačne žlezde

Aleksandar B Oroz; Zorana  Bokun; Djordje  Antonijević; Jasna  Jevdjić

doi:10.2298/VSP170320001O

Aleksandar B Oroz Clinical Center Zemun, Department for Otorinolaringology and Maxillofacial Surgery, Belgrade, Serbia
Zorana Bokun Clinical Center Zemun, Department of Pathology, Belgrade, Serbia
Djordje Antonijević University of Belgrade, Faculty of Medicine, ‡Institute for Anatomy, Belgrade, Serbia
Jasna Jevdjić Clinical Center Kragujevac, Department for Anesthesiology and Reanimation, Kragujevac, Serbia

DOI: https://doi.org/10.2298/VSP170320001O

Keywords: biopsija tankom iglom, biopsija iglom, dijagnoza, histološke tehnike, parotidne žlezde, neoplazme, senzitivnost i specifičnost, submandibularne žlezde, neoplazme

Abstract

Apstrakt

Uvod/Cilj. Dijagnoza tumora pljuvačnih žlezda se pretežno zasniva na radiološkom ispitivanju i histološkoj analizi patološke mase dobijene biopsijom. Cilj rada bio je da se ispitaju specifičnost, senzitivnost i tačnost biopsije šupljom iglom u dijagnozi bolesnika sa oboljenjima parotidne i submandibularne pljuvačne žlezde. Metode. Istraživanje je sprovedeno kao studija preseka u Odeljenju za otorinolaringologiju i maksilofacijalnu hirurgiju Kliničkog centra Zemun, Beograd, u periodu od maja 2008. do maja 2016. godine Studijom je bilo obuhvaćeno 200 bolesnika od kojih je kod 100 bio dijagnostikovan tumor u doušnoj pljuvačnoj žlezdi a kod 100 tumor u podviličnoj pljuvačnoj žlezdi. Biopsija šupljom iglom je bila sprovedena kod svih bolesnika kod kojih je tumor bio manji od 2 centimetara, udaljen od krvnih sudova i udaljen od dubokog režnja doušne pljuvačne žlezde. Posle toga je histološkim nalazom utvrđivan tip promene. Posle sprovođenja hirurške intervencije i potpunog uklanjanja obolelog tkiva, uzorak je ispitan za uspostavljanje konačne dijagnoze. Rezultati. Senzitivnost postupka iznosila je 90,9% za doušnu pljuvačnu žlezdu i 74% za podviličnu pljuvačnu žlezdu; specifičnost je bila 95,9% za doušnu pljuvačnu žlezdu; 93% za podviličnu pljuvačnu žlezdu i preciznost je bila 94,7% za doušnu pljuvačnu žlezdu i 87% za podviličnu pljuvačnu žlezdu. Na osnovu histopatološkog nalaza biopsije šupljom iglom bilo je moguće diferencirati maligne od benignih lezija. Zaključak. Sprovedeno istraživanje ukazuje na prednost i efikasnost biopsije šupljom iglom u dijagnozi tumefakata doušne i podvilične pljuvačne žlezde.

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