Cervical poorly differentiated adenocarcinoma with dominant choriocarcinomatous pattern – A case report

Branka S Nikolić; Aleksandar Ćurković; Svetlana Dragojevic Dikic; Ana Mitrović; Igor Kuzmanović; Aleksandra Arandjelović; Goran Stanković

doi:10.2298/4588

Branka S Nikolić Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
Aleksandar Ćurković Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
Svetlana Dragojevic Dikic G/O Clinic Narodni front, Belgrade, Serbia University of Belgrade, Medical Faculty
Ana Mitrović Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
Igor Kuzmanović Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia
Aleksandra Arandjelović Clinical Hospital Center “Zvezdara”, Belgrade, Serbia
Goran Stanković Faculty of Medicine, University of Belgrade, Belgrade, Serbia Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia

DOI: https://doi.org/10.2298/4588

Keywords: uterine cervical neoplasms, adenocarcinoma, choriocarcinoma, comorbidity, histology, gynecologic surgical procedures,

Abstract

Introduction. Gestational trophoblastic neoplasm (GTN), choriocarcinoma in coexistence with primary cervical adenocarcinoma, is a rare event not easy to diagnose. Choriocarcinoma is a malignant form of GTN but curable if metastases do not appear early and spread fast. Case report. We presented choriocarcinoma in coexistence with primary cervical adenocarcinoma in a 48-year-old patient who had radical hysterectomy because of confirmed cervical carcinoma (Dg: Carcinoma porto vaginalis uteri FIGO st I B1). Histological findings confirmed cervical choriocarcinoma with extensive vascular invasion and apoptosis but GTN choriocarcinoma was finally confirmed after immunohystochemical examinations. Preoperative serum human gonadotropine (beta hCG) level stayed unknown. This patient did not have any pregnancy-like symptoms before the operation. The first beta hCG monitoring was done two months after the operation and found negative. According to the final diagnosis the decision of Consilium for Malignant Diseases was that this patient needed serum hCG monitoring as well as treatment with chemotherapy for high-risk GTN and consequent irradiation for adenocarcinoma. Conclusion. The early and proper diagnosis of nonmetastatic choriocarcinoma of nongestational origine in coexistence with cervical carcinoma is curable and can have good prognosis.

Author Biographies

Branka S Nikolić, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia

Head of dept of Gynecology

Reviewer: Central European J of Medicine

Cancer Therapy

Journal of Case Reports

International J of Gyn Cancer

Srpski arhiv

Vojnosanitetski pregled

Aleksandar Ćurković, Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia

Preoperative care Department

Subspecialist of Perinatology

Svetlana Dragojevic Dikic, G/O Clinic Narodni front, Belgrade, Serbia University of Belgrade, Medical Faculty

Head of Puerperium ward

Gynecological Endocrinology

Igor Kuzmanović, Gynecology and Obstetrics Clinic “Narodni front”, Belgrade, Serbia

Head of the Pathology Department

Aleksandra Arandjelović, Clinical Hospital Center “Zvezdara”, Belgrade, Serbia

Cardiologist

Goran Stanković, Faculty of Medicine, University of Belgrade, Belgrade, Serbia Clinic for Cardiology, Clinical Center of Serbia, Belgrade, Serbia

Cardiologist

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